MYLIP Gene

Name	myosin regulatory light chain interacting protein
Description	The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMYLIP (also known as IDOL) is a sterol‐responsive E3 ubiquitin ligase that plays a central role in cholesterol homeostasis by targeting the low‐density lipoprotein receptor (LDLR) for ubiquitination and subsequent lysosomal degradation. In so doing, MYLIP limits cellular LDL uptake and contributes to variations in plasma LDL cholesterol levels. Its activity is induced by liver X receptor (LXR) signaling, providing a complementary pathway to classic SREBP‐mediated regulation of cholesterol synthesis and uptake. This clathrin‐independent internalization of LDLR further underscores the importance of MYLIP in maintaining lipid balance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent mechanistic studies have provided crucial insight into the regulation and structure–function relationships underpinning MYLIP activity. Conserved FERM and RING domains mediate both substrate recognition and ubiquitin transfer—with MYLIP partnering with specific E2 ubiquitin–conjugating enzymes (such as the UBE2D family) to ubiquitinate its targets. In addition, MYLIP function is fine-tuned by posttranslational modifications; for example, SUMOylation can counteract its autoubiquitination, thereby enhancing protein stability, while interference by deubiquitylases further modulates its activity. Notably, mutations such as the G51S substitution heighten MYLIP’s capacity to promote LDLR degradation, emphasizing the complex regulatory mechanisms that govern its function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nComprehensive genetic studies, including genome‐wide association analyses, have linked MYLIP variants with altered lipid profiles and cardiovascular risk. Several single nucleotide polymorphisms—including the functional N342S variant—affect MYLIP’s ability to induce LDLR degradation, thereby modifying circulating LDL cholesterol levels and contributing to dyslipidemia in diverse populations. These genetic associations reinforce the significance of MYLIP as a potential target for therapeutic intervention aimed at modulating LDLR abundance and lowering cardiovascular disease risk."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its pivotal role in lipid regulation, MYLIP has emerging functions in extra‐hepatic tissues. In the nervous system, for example, MYLIP interacts with proteins such as MIR-interacting saposin-like protein (MSAP) to regulate neurite outgrowth and neuronal morphology. Altered MYLIP expression is also evident in vascular cells and monocytes, where it may influence endothelial function and inflammatory responses—findings that extend its impact to conditions such as diabetes and even certain malignancies mediated by microRNA networks. These diverse roles highlight the broader physiological relevance of MYLIP and underscore its potential as a multifaceted therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "24", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Noam Zelcer, Cynthia Hong, Rima Boyadjian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1168974"}], "href": "https://doi.org/10.1126/science.1168974"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19520913"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19520913"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Dan Lindholm, Beat C Bornhauser, Laura Korhonen "}, {"type": "b", "children": [{"type": "t", "text": "Mylip makes an Idol turn into regulation of LDL receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-009-0127-y"}], "href": "https://doi.org/10.1007/s00018-009-0127-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19688294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19688294"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Bin Dong, Minhao Wu, Aiqin Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of Idol expression is an additional mechanism underlying statin-induced up-regulation of hepatic LDL receptor expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2010.559"}], "href": "https://doi.org/10.3892/ijmm.2010.559"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21069265"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21069265"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Vincenzo Sorrentino, Lilith Scheer, Ana Santos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct functional domains contribute to degradation of the low density lipoprotein receptor (LDLR) by the E3 ubiquitin ligase inducible Degrader of the LDLR (IDOL)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.249557"}], "href": "https://doi.org/10.1074/jbc.M111.249557"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21734303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21734303"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hai Thi Do, Timofey V Tselykh, Johanna Mäkelä, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.341248"}], "href": "https://doi.org/10.1074/jbc.M112.341248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22378787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22378787"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Vincenzo Sorrentino, Jessica K Nelson, Elena Maspero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M037713"}], "href": "https://doi.org/10.1194/jlr.M037713"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23733886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23733886"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jessica Kristine Nelson, Vincenzo Sorrentino, Rossella Avagliano Trezza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.115.307298"}], "href": "https://doi.org/10.1161/CIRCRESAHA.115.307298"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26666640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26666640"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jessica Kristine Nelson, Emma Clare Laura Cook, Anke Loregger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.698688"}], "href": "https://doi.org/10.1074/jbc.M115.698688"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26719329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26719329"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Li Zhang, Louise Fairall, Benjamin T Goult, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.2056211"}], "href": "https://doi.org/10.1101/gad.2056211"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21685362"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21685362"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Anke Loregger, Emma Claire Laura Cook, Jessica Kristin Nelson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00890-15"}], "href": "https://doi.org/10.1128/MCB.00890-15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26527619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26527619"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Cai-ping Zhang, Ying Tian, Min Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IDOL, inducible degrader of low-density lipoprotein receptor, serves as a potential therapeutic target for dyslipidemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Hypotheses (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mehy.2015.11.010"}], "href": "https://doi.org/10.1016/j.mehy.2015.11.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26601593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26601593"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Luca Martinelli, Athanassios Adamopoulos, Patrik Johansson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA120.014349"}], "href": "https://doi.org/10.1074/jbc.RA120.014349"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32727844"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32727844"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ju-Qiong Wang, Zi-Cun Lin, Liang-Liang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA120.015420"}], "href": "https://doi.org/10.1074/jbc.RA120.015420"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33154164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33154164"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Sum Lam, David Tak Wai Lui, Sammy Wing Ming Shiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of type 2 diabetes on the inducible degrader of LDL receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jlr.2023.100380"}], "href": "https://doi.org/10.1016/j.jlr.2023.100380"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37094639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37094639"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Mari Ohmura-Hoshino, Yohei Matsuki, Masami Aoki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of MHC class II expression and immune responses by c-MIR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.177.1.341"}], "href": "https://doi.org/10.4049/jimmunol.177.1.341"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16785530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16785530"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Daniel I Chasman, Guillaume Paré, Samia Mora, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1000730"}], "href": "https://doi.org/10.1371/journal.pgen.1000730"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19936222"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19936222"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Dawn M Waterworth, Sally L Ricketts, Kijoung Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants influencing circulating lipid levels and risk of coronary artery disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.109.201020"}], "href": "https://doi.org/10.1161/ATVBAHA.109.201020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20864672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20864672"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Ting-Ting Yan, Rui-Xing Yin, Qing Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of MYLIP rs3757354 SNP and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lipids Health Dis (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-511X-11-141"}], "href": "https://doi.org/10.1186/1476-511X-11-141"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23107276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23107276"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Rui-Xing Yin, Dong-Feng Wu, Lynn Htet Htet Aung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Several lipid-related gene polymorphisms interact with overweight/obesity to modulate blood pressure levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms130912062"}], "href": "https://doi.org/10.3390/ijms130912062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23109900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23109900"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Anna C Calkin, Stephen D Lee, Jason Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transgenic expression of dominant-active IDOL in liver causes diet-induced hypercholesterolemia and atherosclerosis in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.115.304440"}], "href": "https://doi.org/10.1161/CIRCRESAHA.115.304440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24935961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24935961"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Ashish Dhyani, Gianpaolo Tibolla, Andrea Baragetti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IDOL N342S Variant, Atherosclerosis Progression and Cardiovascular Disorders in the Italian General Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0122414"}], "href": "https://doi.org/10.1371/journal.pone.0122414"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25927920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25927920"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Katrina Mitchel, Elizabeth Theusch, Celia Cubitt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RP1-13D10.2 Is a Novel Modulator of Statin-Induced Changes in Cholesterol."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Cardiovasc Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCGENETICS.115.001274"}], "href": "https://doi.org/10.1161/CIRCGENETICS.115.001274"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27071970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27071970"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Dilare Adi, Jialin Abuzhalihan, Ying-Hong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IDOL gene variant is associated with hyperlipidemia in Han population in Xinjiang, China."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-71241-1"}], "href": "https://doi.org/10.1038/s41598-020-71241-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32868861"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32868861"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Beat C Bornhauser, Per-Anders Olsson, Dan Lindholm "}, {"type": "b", "children": [{"type": "t", "text": "MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M306271200"}], "href": "https://doi.org/10.1074/jbc.M306271200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12826659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12826659"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Georgios Kararigas, Virginie Bito, Hanna Tinel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome characterization of estrogen-treated human myocardium identifies myosin regulatory light chain interacting protein as a sex-specific element influencing contractile function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Coll Cardiol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jacc.2011.09.054"}], "href": "https://doi.org/10.1016/j.jacc.2011.09.054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22261164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22261164"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Salam Ibrahim, Suryanarayan Somanathan, Jeffrey Billheimer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stable liver-specific expression of human IDOL in humanized mice raises plasma cholesterol."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvw010"}], "href": "https://doi.org/10.1093/cvr/cvw010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26786161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26786161"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Ming Ni, Qin Yan, Hui Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of MYLIP gene and miRNA-802 involved in the growth and metastasis of cervical cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-201523"}], "href": "https://doi.org/10.3233/CBM-201523"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33185588"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33185588"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Isaura Martins, Dalila Neves-Silva, Mariana Ascensão-Ferreira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse Spinal Cord Vascular Transcriptome Analysis Identifies CD9 and MYLIP as Injury-Induced Players."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms24076433"}], "href": "https://doi.org/10.3390/ijms24076433"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37047406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37047406"}]}]}]}
Synonyms	IDOL
Proteins	MYLIP_HUMAN
NCBI Gene ID	29116
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MYLIP has 7,430 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 112 datasets.

Click the + buttons to view associations for MYLIP from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MYLIP Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by MYLIP gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MYLIP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MYLIP gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MYLIP gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MYLIP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MYLIP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MYLIP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MYLIP gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MYLIP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MYLIP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MYLIP gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MYLIP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MYLIP gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MYLIP gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MYLIP gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MYLIP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MYLIP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MYLIP gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MYLIP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MYLIP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MYLIP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MYLIP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MYLIP gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MYLIP gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MYLIP gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MYLIP gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MYLIP gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MYLIP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MYLIP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MYLIP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MYLIP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MYLIP gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MYLIP gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MYLIP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MYLIP from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with MYLIP gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of MYLIP gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MYLIP gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MYLIP from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of MYLIP gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.