| HGNC Family | Fibronectin type III domain containing, Immunoglobulin superfamily domain containing |
| Name | myosin light chain kinase |
| Description | This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMYLK, the gene encoding myosin light chain kinase (MLCK), plays a central role in regulating actomyosin contractility by phosphorylating myosin regulatory light chains—a process essential for cytoskeletal dynamics that, in turn, governs epithelial barrier integrity. In intestinal and pulmonary epithelial cells, proinflammatory cytokines such as tumor necrosis factor‐α, interleukin‐1β, interleukin‐18, and interferon‐γ have been shown to up‐regulate MYLK transcription and protein expression. This elevation in MLCK activity leads to increased myosin light chain phosphorylation, tight junction disruption, enhanced paracellular permeability, and augmented leukocyte transmigration. Moreover, transcriptional regulation via NF‐κB, AP‐1, and Sp1, as well as posttranslational targeting of specific MLCK splice variants (e.g., MLCK1), underlies these barrier‐modulatory effects—a process that can be pharmacologically modulated by agents that prevent MLCK recruitment even without directly inhibiting its enzymatic activity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn vascular smooth muscle cells, as well as in related cells including airway smooth muscle and platelets, MLCK‐mediated phosphorylation is fundamental to cellular contraction and relaxation that ultimately modulates vascular tone, blood pressure, and airway responsiveness. Numerous studies have linked dysregulation of MYLK to a spectrum of cardiovascular and pulmonary diseases, such as familial thoracic aortic aneurysms/dissections, sepsis‐associated acute lung injury, asthma, and hypertension. In addition, MLCK activity is integral to processes including epithelial wound closure, platelet activation, and cell migration—phenomena that underscore its pivotal role in both normal physiology and the pathogenesis of inflammatory and malignant states."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its classical roles in regulating contraction, MYLK is subject to a multifaceted network of regulatory mechanisms that modulate cell motility and invasiveness, particularly in cancer. Interactions between MLCK and key cytoskeletal regulators—such as cortactin and the acetyltransferase hARD1—as well as post‐transcriptional regulation by specific microRNAs, finely tune MLCK activity and subcellular localization. These dynamics control not only conventional actomyosin contractility but also the formation of invadopodia and other cellular protrusions that facilitate tumor cell migration and metastasis. Such insights into the regulatory nuances of MYLK highlight its promise as a therapeutic target in diverse pathologic contexts ranging from inflammatory disorders to cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "30", "end_ref": "34"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Steven M Dudek, Jeffrey R Jacobson, Eddie T Chiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M313969200"}], "href": "https://doi.org/10.1074/jbc.M313969200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15056655"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15056655"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Daniel R Clayburgh, Shari Rosen, Edwina D Witkowski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M408822200"}], "href": "https://doi.org/10.1074/jbc.M408822200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15507455"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15507455"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Fengjun Wang, W Vallen Graham, Yingmin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0002-9440(10)62264-x"}], "href": "https://doi.org/10.1016/s0002-9440(10"}, {"type": "t", "text": "62264-x) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15681825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15681825"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "W Vallen Graham, Fengjun Wang, Daniel R Clayburgh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M602164200"}], "href": "https://doi.org/10.1074/jbc.M602164200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16835238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16835238"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Dongmei Ye, Thomas Y Ma "}, {"type": "b", "children": [{"type": "t", "text": "Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-alpha-induced regulation of myosin light chain kinase gene activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1582-4934.2008.00302.x"}], "href": "https://doi.org/10.1111/j.1582-4934.2008.00302.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18363837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18363837"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Tamia K Lapointe, Andre G Buret "}, {"type": "b", "children": [{"type": "t", "text": "Interleukin-18 facilitates neutrophil transmigration via myosin light chain kinase-dependent disruption of occludin, without altering epithelial permeability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Gastrointest Liver Physiol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpgi.00202.2011"}], "href": "https://doi.org/10.1152/ajpgi.00202.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22135309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22135309"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Rana Al-Sadi, Shuhong Guo, Dongmei Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism of IL-1β modulation of intestinal epithelial barrier involves p38 kinase and activating transcription factor-2 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1201876"}], "href": "https://doi.org/10.4049/jimmunol.1201876"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23656735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23656735"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Li-Ling Wu, Wei-Hao Peng, Wei-Ting Kuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Commensal bacterial endocytosis in epithelial cells is dependent on myosin light chain kinase-activated brush border fanning by interferon-γ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2014.05.003"}], "href": "https://doi.org/10.1016/j.ajpath.2014.05.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24911373"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24911373"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Aditya Garg, Angela Zhao, Sarah L Erickson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pharmacol Exp Ther (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/jpet.116.234096"}], "href": "https://doi.org/10.1124/jpet.116.234096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27440420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27440420"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Akihiro Watari, Yuta Sakamoto, Kota Hisaie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rebeccamycin Attenuates TNF-α-Induced Intestinal Epithelial Barrier Dysfunction by Inhibiting Myosin Light Chain Kinase Production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000472367"}], "href": "https://doi.org/10.1159/000472367"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28391269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28391269"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "W Vallen Graham, Weiqi He, Amanda M Marchiando, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41591-019-0393-7"}], "href": "https://doi.org/10.1038/s41591-019-0393-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30936544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30936544"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "K Vinod Vijayan, Yan Liu, Jing-Fei Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced activation of mitogen-activated protein kinase and myosin light chain kinase by the Pro33 polymorphism of integrin beta 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M208680200"}], "href": "https://doi.org/10.1074/jbc.M208680200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12460991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12460991"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Priscilla M Clarkson, Eric P Hoffman, Edward Zambraski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ACTN3 and MLCK genotype associations with exertional muscle damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Appl Physiol (1985) (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/japplphysiol.00130.2005"}], "href": "https://doi.org/10.1152/japplphysiol.00130.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15817725"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15817725"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "John M Russo, Peter Florian, Le Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2005.01.004"}], "href": "https://doi.org/10.1053/j.gastro.2005.01.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15825080"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15825080"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Shunichi Shimizu, Takashi Yoshida, Minoru Wakamori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2005.097998"}], "href": "https://doi.org/10.1113/jphysiol.2005.097998"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16284075"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16284075"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Li Gao, Audrey Grant, Indrani Halder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2005-0404OC"}], "href": "https://doi.org/10.1165/rcmb.2005-0404OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16399953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16399953"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Carlos Flores, Shwu-Fan Ma, Karen Maresso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Epidemiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gepi.20210"}], "href": "https://doi.org/10.1002/gepi.20210"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17266121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17266121"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Li Gao, Audrey V Grant, Nicholas Rafaels, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2007.03.019"}], "href": "https://doi.org/10.1016/j.jaci.2007.03.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17472811"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17472811"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Qi Zhao, Laiyuan Wang, Wei Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interactions among genetic variants from contractile pathway of vascular smooth muscle cell in essential hypertension susceptibility of Chinese Han population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenet Genomics (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/FPC.0b013e3282f97fb2"}], "href": "https://doi.org/10.1097/FPC.0b013e3282f97fb2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18496125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18496125"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Xiaolei Zhou, Yi Liu, Jiacong You, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2008.05.028"}], "href": "https://doi.org/10.1016/j.canlet.2008.05.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18710790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18710790"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jason D Christie, Shwu-Fan Ma, Richard Aplenc, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Crit Care Med (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/ccm.0b013e318186b843"}], "href": "https://doi.org/10.1097/ccm.0b013e318186b843"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18828194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18828194"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Renaud Léguillette, Michel Laviolette, Celine Bergeron, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myosin, transgelin, and myosin light chain kinase: expression and function in asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Crit Care Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1164/rccm.200609-1367OC"}], "href": "https://doi.org/10.1164/rccm.200609-1367OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19011151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19011151"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Benjamin D Horne, Elizabeth R Hauser, Liyong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hum Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1469-1809.2009.00540.x"}], "href": "https://doi.org/10.1111/j.1469-1809.2009.00540.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19706030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19706030"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Eric C Wooten, Lakshmanan K Iyer, Maria Claudia Montefusco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0008830"}], "href": "https://doi.org/10.1371/journal.pone.0008830"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20098615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20098615"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Christina M Godin, Stephen S G Ferguson "}, {"type": "b", "children": [{"type": "t", "text": "The angiotensin II type 1 receptor induces membrane blebbing by coupling to Rho A, Rho kinase, and myosin light chain kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.110.063859"}], "href": "https://doi.org/10.1124/mol.110.063859"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20181817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20181817"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Steven M Dudek, Eddie T Chiang, Sara M Camp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E09-10-0876"}], "href": "https://doi.org/10.1091/mbc.E09-10-0876"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20861316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20861316"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Li Wang, Dong-chuan Guo, Jiumei Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in myosin light chain kinase cause familial aortic dissections."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2010.10.006"}], "href": "https://doi.org/10.1016/j.ajhg.2010.10.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21055718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21055718"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "A Martinsen, C Dessy, N Morel "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of calcium channels in smooth muscle: new insights into the role of myosin light chain kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Channels (Austin) (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/19336950.2014.950537"}], "href": "https://doi.org/10.4161/19336950.2014.950537"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25483583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25483583"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Shaquria P Adderley, Xun E Zhang, Jerome W Breslin "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of the H1 Histamine Receptor, p38 MAP Kinase, Myosin Light Chains Kinase, and Rho/ROCK in Histamine-Induced Endothelial Barrier Dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Microcirculation (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/micc.12189"}], "href": "https://doi.org/10.1111/micc.12189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25582918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25582918"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Cécile Oury, Elsie Sticker, Heidi Cornelissen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ATP augments von Willebrand factor-dependent shear-induced platelet aggregation through Ca2+-calmodulin and myosin light chain kinase activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M402032200"}], "href": "https://doi.org/10.1074/jbc.M402032200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15087444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15087444"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Dong Hoon Shin, Yang-Sook Chun, Kyoung-Hwa Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0007451"}], "href": "https://doi.org/10.1371/journal.pone.0007451"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19826488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19826488"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Vignesh Sundararajan, Nicolas Gengenbacher, Marc P Stemmler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ZEB1/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.4807"}], "href": "https://doi.org/10.18632/oncotarget.4807"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26334100"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26334100"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Amol Bhargava, James A Cotton, Brent R Dixon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Giardia duodenalis Surface Cysteine Proteases Induce Cleavage of the Intestinal Epithelial Cytoskeletal Protein Villin via Myosin Light Chain Kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0136102"}], "href": "https://doi.org/10.1371/journal.pone.0136102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26334299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26334299"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "A Y Khapchaev, V P Shirinsky "}, {"type": "b", "children": [{"type": "t", "text": "Myosin Light Chain Kinase MYLK1: Anatomy, Interactions, Functions, and Regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (Mosc) (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1134/S000629791613006X"}], "href": "https://doi.org/10.1134/S000629791613006X"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28260490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28260490"}]}]}]}
|
| Synonyms | MLCK, KRP, MYLK1, MSTP083, MLCK210, MLCK1, MLCK108, AAT7, SMMLCK |
| Proteins | MYLK_HUMAN |
| NCBI Gene ID | 4638 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
MYLK has 11,674 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 143 datasets.
Click the + buttons to view associations for MYLK from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of MYLK gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of MYLK gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MYLK gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of MYLK gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of MYLK gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of MYLK gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| Biocarta Pathways | pathways involving MYLK protein from the Biocarta Pathways dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of MYLK gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of MYLK gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of MYLK gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of MYLK gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MYLK gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of MYLK gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene Mutation Profiles | cell lines with MYLK gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with MYLK protein from the CCLE Cell Line Proteomics dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with MYLK gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MYLK gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of MYLK gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of MYLK gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| ClinVar Gene-Phenotype Associations | phenotypes associated with MYLK gene from the curated ClinVar Gene-Phenotype Associations dataset. | |
| ClinVar Gene-Phenotype Associations 2025 | phenotypes associated with MYLK gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MYLK gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing MYLK protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing MYLK protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing MYLK protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with MYLK protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with MYLK protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MYLK gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with MYLK gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with MYLK gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with MYLK gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| dbGAP Gene-Trait Associations | traits associated with MYLK gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of MYLK protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by MYLK gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores | diseases involving MYLK gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving MYLK gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with MYLK gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with MYLK gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with MYLK gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with MYLK gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MYLK gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MYLK gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of MYLK gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing MYLK from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with MYLK gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with MYLK gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of MYLK gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with MYLK gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing MYLK from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of MYLK gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of MYLK gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of MYLK gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MYLK gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of MYLK gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of MYLK gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving MYLK gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving MYLK gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving MYLK gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing MYLK protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing MYLK protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing MYLK protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by MYLK gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by MYLK gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by MYLK gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of MYLK gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of MYLK gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MYLK gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of MYLK gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| Guide to Pharmacology Protein Ligands of Receptors | ligands (protein) binding MYLK receptor from the curated Guide to Pharmacology Protein Ligands of Receptors dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with MYLK gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with MYLK gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with MYLK gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of MYLK gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HMDB Metabolites of Enzymes | interacting metabolites for MYLK protein from the curated HMDB Metabolites of Enzymes dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of MYLK gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of MYLK gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of MYLK protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MYLK gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HPO Gene-Disease Associations | phenotypes associated with MYLK gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for MYLK from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with MYLK gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with MYLK gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for MYLK protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of MYLK gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of MYLK gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of MYLK gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEA Substrates of Kinases | kinases that phosphorylate MYLK protein from the curated KEA Substrates of Kinases dataset. | |
| KEGG Pathways | pathways involving MYLK protein from the KEGG Pathways dataset. | |
| KEGG Pathways 2026 | pathways involving MYLK protein from the KEGG Pathways 2026 dataset. | |
| Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate MYLK protein from the Kinase Library Serine Threonine Atlas dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MYLK gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of MYLK gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with MYLK gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of MYLK gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS KinomeScan Kinase Inhibitor Targets | small molecules inhibiting MYLK kinase from the KinomeScan Kinase Inhibitor Targets dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of MYLK gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of MYLK gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MYLK gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing MYLK protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain MYLK protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by MYLK gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting MYLK gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MYLK gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of MYLK gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by MYLK gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of MYLK gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of MYLK gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| NURSA Protein Complexes | protein complexs containing MYLK protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| OMIM Gene-Disease Associations | phenotypes associated with MYLK gene from the curated OMIM Gene-Disease Associations dataset. | |
| PANTHER Pathways | pathways involving MYLK protein from the PANTHER Pathways dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for MYLK from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of MYLK gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of MYLK gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving MYLK protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving MYLK protein from the Wikipathways PFOCR 2024 dataset. | |
| Phosphosite Textmining Biological Term Annotations | biological terms co-occuring with MYLK protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset. | |
| PhosphoSitePlus Substrates of Kinases | kinases that phosphorylate MYLK protein from the curated PhosphoSitePlus Substrates of Kinases dataset. | |
| PID Pathways | pathways involving MYLK protein from the PID Pathways dataset. | |
| ProteomicsDB Cell Type and Tissue Protein Expression Profiles | cell types and tissues with high or low expression of MYLK protein relative to other cell types and tissues from the ProteomicsDB Cell Type and Tissue Protein Expression Profiles dataset. | |
| Reactome Pathways 2014 | pathways involving MYLK protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving MYLK protein from the Reactome Pathways 2024 dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of MYLK gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of MYLK gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of MYLK gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MYLK gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of MYLK gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of MYLK gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with MYLK protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of MYLK gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| SynGO Synaptic Gene Annotations | synaptic terms associated with MYLK gene from the SynGO Synaptic Gene Annotations dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of MYLK gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| Tahoe Therapeutics Tahoe 100M Perturbation Atlas | drug perturbations changing expression of MYLK gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of MYLK gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of MYLK gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of MYLK gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of MYLK protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of MYLK protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of MYLK protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of MYLK protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with MYLK protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with MYLK protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2014 | pathways involving MYLK protein from the Wikipathways Pathways 2014 dataset. | |
| WikiPathways Pathways 2024 | pathways involving MYLK protein from the WikiPathways Pathways 2024 dataset. | |
