{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have highlighted the pivotal role of long noncoding RNAs (lncRNAs) acting as competitive endogenous RNAs (ceRNAs) in cancer development. In muscle-invasive bladder cancer (MIBC), RNA sequence profiling led to the construction of a ceRNA network comprising aberrantly expressed mRNAs, lncRNAs, and miRNAs, among which MYO16‐AS1 was identified. This network provided insights into the molecular mechanisms underlying tumor progression in MIBC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nWithin this network, MYO16‐AS1 emerged as one of eight lncRNAs that form a prognostic signature for MIBC. Its elevated expression was statistically correlated with worsened overall survival in patients, suggesting that MYO16‐AS1 plays a significant oncogenic role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, experimental assays demonstrated that overexpression of MYO16‐AS1 enhanced UMUC2 cell migration and invasion, confirming its functional contribution to bladder cancer progression. These findings propose that MYO16‐AS1 may serve as both a biomarker for prognostic prediction and a potential therapeutic target in MIBC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Danyang Shen, Youyun Zhang, Qiming Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Competing Endogenous RNA Network and an 8-lncRNA Prognostic Signature Identify "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MYO16-AS1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " as an Oncogenic lncRNA in Bladder Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2020.6014"}], "href": "https://doi.org/10.1089/dna.2020.6014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33270518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33270518"}]}]}]}