HGNC Family | Baculoviral IAP repeat containing (BIRC), NLR family (NLR) |
Name | NLR family, apoptosis inhibitory protein |
Description | This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNeuronal apoptosis inhibitory protein (NAIP) is a multifunctional protein best known for its role in innate immunity. NAIP acts as a cytosolic sensor that detects bacterial virulence factors—including type III secretion system needle proteins and flagellin—thereby nucleating the assembly of the NLRC4 inflammasome complex. This activation triggers caspase‐1–dependent cellular responses that promote inflammatory cytokine release and pyroptosis, a process fundamental to host defense against diverse pathogens such as Salmonella, Shigella, and Legionella. In addition, NAIP gene dosage can modulate the amplitude of this response, suggesting that higher NAIP levels may intensify inflammasome-dependent cell death upon pathogen encounter."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its immune-sensing role, NAIP exerts significant antiapoptotic activity. Its unique structure—which integrates baculoviral inhibitory repeat (BIR), nucleotide-binding oligomerization (NOD), and leucine-rich repeat (LRR) domains—enables NAIP to interact with and inhibit caspase-9 during apoptosome assembly in an ATP-dependent manner. This property prevents premature or excessive activation of the intrinsic apoptosis pathway and safeguards cell viability. Moreover, NAIP expression is governed by a complex transcriptional architecture, including multiple distinct promoters and the exaptation of endogenous retroviral long terminal repeats (LTRs) and Alu elements, further underscoring its finely tuned regulatory control."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNAIP’s multifunctionality is also evident in its impact on disease modulation, particularly in neurodegenerative and neuromuscular contexts. In spinal muscular atrophy (SMA), for example, deletion or reduced copy number of the NAIP gene correlates with increased disease severity and earlier onset, highlighting its role as a modifier of neuronal survival. Differential NAIP expression in both neuronal and non-neuronal cells further influences susceptibility to apoptosis in diverse tissues. Intriguingly, emerging data also implicate NAIP in nonapoptotic processes such as cytokinesis, suggesting additional cellular functions that may contribute to tissue homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jieling Yang, Yue Zhao, Jianjin Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1306376110"}], "href": "https://doi.org/10.1073/pnas.1306376110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23940371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23940371"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Els F Halff, Christoph A Diebolder, Marian Versteeg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.393512"}], "href": "https://doi.org/10.1074/jbc.M112.393512"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23012363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23012363"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jens Kortmann, Sky W Brubaker, Denise M Monack "}, {"type": "b", "children": [{"type": "t", "text": "Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1403100"}], "href": "https://doi.org/10.4049/jimmunol.1403100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26109648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26109648"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Maya Vinzing, Julia Eitel, Juliane Lippmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAIP and Ipaf control Legionella pneumophila replication in human cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.180.10.6808"}], "href": "https://doi.org/10.4049/jimmunol.180.10.6808"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18453601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18453601"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yinhong Zhang, Jing He, Yunqian Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The analysis of the association between the copy numbers of survival motor neuron gene 2 and neuronal apoptosis inhibitory protein genes and the clinical phenotypes in 40 patients with spinal muscular atrophy: Observational study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000018809"}], "href": "https://doi.org/10.1097/MD.0000000000018809"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32011487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32011487"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jamshid Davoodi, Lily Lin, John Kelly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M405963200"}], "href": "https://doi.org/10.1074/jbc.M405963200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15280366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15280366"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jamshid Davoodi, Mohammad-Hossein Ghahremani, Ali Es-Haghi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuronal apoptosis inhibitory protein, NAIP, is an inhibitor of procaspase-9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2010.02.008"}], "href": "https://doi.org/10.1016/j.biocel.2010.02.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20171302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20171302"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sarvenaz Karimpour, Jamshid Davoodi, Mohammad-Hossein Ghahremani "}, {"type": "b", "children": [{"type": "t", "text": "Integrity of ATP binding site is essential for effective inhibition of the intrinsic apoptosis pathway by NAIP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2011.02.130"}], "href": "https://doi.org/10.1016/j.bbrc.2011.02.130"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21371431"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21371431"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Mark T Romanish, Wynne M Lock, Louie N van de Lagemaat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Repeated recruitment of LTR retrotransposons as promoters by the anti-apoptotic locus NAIP during mammalian evolution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.0030010"}], "href": "https://doi.org/10.1371/journal.pgen.0030010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17222062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17222062"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Mark T Romanish, Hisae Nakamura, C Benjamin Lai, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Combination of SMN2 copy number and NAIP deletion predicts disease severity in spinal muscular atrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Dev (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.braindev.2008.08.012"}], "href": "https://doi.org/10.1016/j.braindev.2008.08.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18842367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18842367"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Mohd Shamshudin Watihayati, Azhar-Mohd-Hussin Zabidi, Thean Hock Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAIP-deletion analysis in Malaysian patients with spinal muscular atrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kobe J Med Sci (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17932457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17932457"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Johannes K X Maier, Sylvia Balabanian, Cynthia R Coffill, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distribution of neuronal apoptosis inhibitory protein in human tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Histochem Cytochem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1369/jhc.6A7144.2007"}], "href": "https://doi.org/10.1369/jhc.6A7144.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17510375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17510375"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yu-jin Qu, Xiu-shan Ge, Jin-li Bai, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Molecular genetics of spinal muscular atrophy: contribution of the NAIP gene to clinical severity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kobe J Med Sci (2002)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11912351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11912351"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Francisco Abadía-Molina, Virginia Morón-Calvente, Stephen D Baird, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuronal apoptosis inhibitory protein (NAIP) localizes to the cytokinetic machinery during cell division."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep39981"}], "href": "https://doi.org/10.1038/srep39981"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28059125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28059125"}]}]}]}
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Synonyms | NLRB1, PSINAIP, BIRC1 |
Proteins | BIRC1_HUMAN |
NCBI Gene ID | 4671 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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NAIP has 4,231 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 92 datasets.
Click the + buttons to view associations for NAIP from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
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Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of NAIP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of NAIP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of NAIP gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of NAIP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of NAIP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of NAIP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with NAIP gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of NAIP gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of NAIP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of NAIP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of NAIP gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing NAIP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing NAIP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with NAIP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with NAIP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
CORUM Protein Complexes | protein complexs containing NAIP protein from the CORUM Protein Complexes dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of NAIP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with NAIP gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with NAIP gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with NAIP gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with NAIP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with NAIP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with NAIP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with NAIP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at NAIP gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of NAIP gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of NAIP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing NAIP from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with NAIP gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with NAIP gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing NAIP from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of NAIP gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of NAIP gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of NAIP gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of NAIP gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of NAIP gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of NAIP gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GO Biological Process Annotations 2015 | biological processes involving NAIP gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving NAIP gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving NAIP gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing NAIP protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing NAIP protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing NAIP protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by NAIP gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by NAIP gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by NAIP gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of NAIP gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of NAIP gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of NAIP gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of NAIP gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of NAIP gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of NAIP gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of NAIP protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of NAIP gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for NAIP from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with NAIP gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for NAIP protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of NAIP gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate NAIP protein from the Kinase Library Serine Threonine Atlas dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of NAIP gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of NAIP gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with NAIP gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of NAIP gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of NAIP gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of NAIP gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of NAIP gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing NAIP protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain NAIP protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by NAIP gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting NAIP gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of NAIP gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MSigDB Cancer Gene Co-expression Modules | co-expressed genes for NAIP from the MSigDB Cancer Gene Co-expression Modules dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of NAIP gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
NURSA Protein Complexes | protein complexs containing NAIP protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for NAIP from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of NAIP gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving NAIP protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving NAIP protein from the Wikipathways PFOCR 2024 dataset. | |
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of NAIP gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of NAIP gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of NAIP gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of NAIP gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of NAIP gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of NAIP gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of NAIP gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of NAIP protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of NAIP protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of NAIP protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of NAIP protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with NAIP protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with NAIP protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
WikiPathways Pathways 2024 | pathways involving NAIP protein from the WikiPathways Pathways 2024 dataset. | |