NALCN Gene

HGNC Family	Ion channels
Name	sodium leak channel, non selective
Description	This gene encodes a voltage-independent, nonselective cation channel which belongs to a family of voltage-gated sodium and calcium channels that regulates the resting membrane potential and excitability of neurons. This family is expressed throughout the nervous system and conducts a persistent sodium leak current that contributes to tonic neuronal excitability. The encoded protein forms a channelosome complex that includes G-protein-coupled receptors, UNC-79, UNC-80, NCA localization factor-1, and src family tyrosine kinases. Naturally occurring mutations in this gene are associated with infantile neuroaxonal dystrophy, infantile hypotonia with psychomotor retardation and characteristic facies (IHPRF) syndrome, and congenital contractures of the limbs and face with hypotonia and developmental delay (CLIFAHDD) syndrome. A knockout of the orthologous gene in mice results in paralysis with a severely disrupted respiratory rhythm, and lethality within 24 hours after birth. [provided by RefSeq, Apr 2017]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNALCN is a highly conserved, voltage‐independent, non‐selective cation channel that mediates a persistent leak of sodium ions, thereby setting the resting membrane potential and modulating neuronal excitability. Structural and functional studies have demonstrated that NALCN operates as part of a macromolecular complex with key auxiliary subunits—including FAM155A, UNC80, and UNC79—that regulate its gating, ion selectivity, and cellular localization. In addition, the channel is modulated by receptor‐mediated signaling pathways that can activate its inward current via mechanisms independent of classic G protein signaling (for example, via muscarinic receptors and Src kinase activation), and recent work has revealed that post‐translational modifications such as arginine methylation further fine‐tune its activity. These properties collectively underscore the central role of NALCN in controlling basal excitability in neurons and other excitable cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic studies in patients have revealed that alterations in NALCN function are linked to a spectrum of neurodevelopmental disorders. Heterozygous, de novo missense mutations—often affecting critical residues in the channel’s pore‐forming segments—can cause congenital syndromes characterized by distal arthrogryposis, facial contractures, hypotonia, and developmental delay, while biallelic loss‐of‐function variants result in infantile hypotonia with psychomotor retardation and distinctive facial features. In several families, mutation-driven disruptions of the NALCN channelosome underlie severe intellectual disability and motor deficits, with the specific clinical presentation determined by whether the mutations produce gain‐of‐function or loss‐of‐function effects. These findings establish NALCN as a critical regulator of neural circuit formation and excitability and highlight the importance of its correct structural and functional integrity for normal neurodevelopment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond the central nervous system, NALCN also plays important roles in peripheral tissues. In pancreatic beta cells, for instance, NALCN is involved in generating sodium currents activated by muscarinic receptor stimulation, thereby contributing to insulin secretion dynamics. Moreover, in myometrial smooth muscle cells, NALCN-mediated leak currents help regulate the excitability that drives uterine contractions, and genetic associations near NALCN have been implicated in movement disorders such as cervical dystonia. Together, these studies reveal that the impact of NALCN extends well beyond neurons, influencing a range of physiological processes through its regulation of membrane excitability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Leigh Anne Swayne, Alexandre Mezghrani, Annie Varrault, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic beta-cell line."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/embor.2009.125"}], "href": "https://doi.org/10.1038/embor.2009.125"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19575010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19575010"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nuria C Bramswig, Aida M Bertoli-Avella, Beate Albrecht, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants in components of the NALCN-UNC80-UNC79 ion channel complex cause a broad clinical phenotype (NALCN channelopathies)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-018-1929-5"}], "href": "https://doi.org/10.1007/s00439-018-1929-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30167850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30167850"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Malik Bouasse, Hathaichanok Impheng, Zoe Servant, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional expression of CLIFAHDD and IHPRF pathogenic variants of the NALCN channel in neuronal cells reveals both gain- and loss-of-function properties."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-48071-x"}], "href": "https://doi.org/10.1038/s41598-019-48071-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31409833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31409833"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jiongfang Xie, Meng Ke, Lizhen Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of the human sodium leak channel NALCN in complex with FAM155A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-19667-z"}], "href": "https://doi.org/10.1038/s41467-020-19667-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33203861"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33203861"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Seul-Yi Lee, Tuan Anh Vuong, Xianlan Wen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methylation determines the extracellular calcium sensitivity of the leak channel NALCN in hippocampal dentate granule cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s12276-019-0325-0"}], "href": "https://doi.org/10.1038/s12276-019-0325-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31601786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31601786"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jinhong Wie, Apoorva Bharthur, Morgan Wolfgang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-17105-8"}], "href": "https://doi.org/10.1038/s41467-020-17105-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32620897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32620897"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Marc Kschonsak, Han Chow Chua, Claudia Weidling, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Rev (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/physrev.00014.2022"}], "href": "https://doi.org/10.1152/physrev.00014.2022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37615954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37615954"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ke-Sheng Wang, Xue-Feng Liu, Nagesh Aragam "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Schizophr Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.schres.2010.09.002"}], "href": "https://doi.org/10.1016/j.schres.2010.09.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20889312"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20889312"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jessica X Chong, Margaret J McMillin, Kathryn M Shively, et al. "}, {"type": "b", "children": [{"type": "t", "text": "De novo mutations in NALCN cause a syndrome characterized by congenital contractures of the limbs and face, hypotonia, and developmental delay."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2015.01.003"}], "href": "https://doi.org/10.1016/j.ajhg.2015.01.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25683120"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25683120"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Moeenaldeen D Al-Sayed, Hamad Al-Zaidan, Albandary Albakheet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in NALCN cause an autosomal-recessive syndrome with severe hypotonia, speech impairment, and cognitive delay."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2013.08.001"}], "href": "https://doi.org/10.1016/j.ajhg.2013.08.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24075186"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24075186"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hanan E Shamseldin, Eissa Faqeih, Ali Alasmari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in UNC80, Encoding Part of the UNC79-UNC80-NALCN Channel Complex, Cause Autosomal-Recessive Severe Infantile Encephalopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2015.11.013"}], "href": "https://doi.org/10.1016/j.ajhg.2015.11.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26708753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26708753"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Eric G Bend, Yue Si, David A Stevenson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NALCN channelopathies: Distinguishing gain-of-function and loss-of-function mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/WNL.0000000000003095"}], "href": "https://doi.org/10.1212/WNL.0000000000003095"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27558372"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27558372"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ryoko Fukai, Hirotomo Saitsu, Nobuhiko Okamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "De novo missense mutations in NALCN cause developmental and intellectual impairment with hypotonia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jhg.2015.163"}], "href": "https://doi.org/10.1038/jhg.2015.163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26763878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26763878"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Moran Gal, Daniella Magen, Younan Zahran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel homozygous splice site mutation in NALCN identified in siblings with cachexia, strabismus, severe intellectual disability, epilepsy and abnormal respiratory rhythm."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Med Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejmg.2016.02.007"}], "href": "https://doi.org/10.1016/j.ejmg.2016.02.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26923739"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26923739"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Mert Karakaya, Raoul Heller, Volkmar Kunde, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel Mutations in the Nonselective Sodium Leak Channel (NALCN) Lead to Distal Arthrogryposis with Increased Muscle Tone."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropediatrics (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1055/s-0036-1584084"}], "href": "https://doi.org/10.1055/s-0036-1584084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27214504"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27214504"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "A Angius, S Cossu, P Uva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel NALCN biallelic truncating mutations in siblings with IHPRF1 syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.13162"}], "href": "https://doi.org/10.1111/cge.13162"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29399786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29399786"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Danielle K Bourque, David A Dyment, Ian MacLusky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Periodic breathing in patients with NALCN mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s10038-018-0484-1"}], "href": "https://doi.org/10.1038/s10038-018-0484-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29968795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29968795"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Renan P Souza, Daniela V F Rosa, Marco A Romano-Silva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lack of association of NALCN genetic variants with schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Psychiatry Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.psychres.2010.07.009"}], "href": "https://doi.org/10.1016/j.psychres.2010.07.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20674038"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20674038"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Sahand Tehrani Fateh, Saman Bagheri, Hossein Sadeghi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extending and outlining the genotypic and phenotypic spectrum of novel mutations of NALCN gene in IHPRF1 syndrome: identifying recurrent urinary tract infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10072-023-06960-0"}], "href": "https://doi.org/10.1007/s10072-023-06960-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37452996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37452996"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Kin Y Mok, Susanne A Schneider, Daniah Trabzuni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomewide association study in cervical dystonia demonstrates possible association with sodium leak channel."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mov Disord (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mds.25732"}], "href": "https://doi.org/10.1002/mds.25732"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24227479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24227479"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Erin L Reinl, Rafael Cabeza, Ismail A Gregory, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sodium leak channel, non-selective contributes to the leak current in human myometrial smooth muscle cells from pregnant women."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Hum Reprod (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/molehr/gav038"}], "href": "https://doi.org/10.1093/molehr/gav038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26134120"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26134120"}]}]}]}
Synonyms	IHPRF1, CLIFAHDD, IHPRF, BA430M15.1, INNFD, CANION, VGCNL1
Proteins	NALCN_HUMAN
NCBI Gene ID	259232
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NALCN has 4,453 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 110 datasets.

Click the + buttons to view associations for NALCN from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NALCN Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NALCN gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NALCN gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NALCN gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NALCN gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NALCN gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NALCN gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NALCN gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NALCN gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NALCN gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NALCN gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with NALCN gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NALCN gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NALCN gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NALCN gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with NALCN gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with NALCN gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NALCN protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NALCN protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing NALCN protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NALCN protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NALCN protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NALCN gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NALCN gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with NALCN gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with NALCN gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of NALCN protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by NALCN gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving NALCN gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving NALCN gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with NALCN gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NALCN gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NALCN gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NALCN gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NALCN gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NALCN gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NALCN gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NALCN gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing NALCN from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with NALCN gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with NALCN gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.