{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn advanced prostate cancer, the long non‑coding RNA lncNAP1L6 is significantly upregulated and acts as an oncogene by promoting key steps in cancer progression. Functional experiments demonstrate that elevated levels of lncNAP1L6 enhance cell migration, invasion, and epithelial‑mesenchymal transition (EMT), while its knockdown has the reverse effect."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic investigations reveal that the METTL3/METTL14 complex mediates m6A methylation of NAP1L2 mRNA, after which lncNAP1L6 recruits the m6A reader protein HNRNPC to stabilize NAP1L2 mRNA. Moreover, lncNAP1L6 interacts with the transcription factor YY1 to drive the transcription of MMP2 and MMP9, thereby activating the matrix metalloproteinase (MMP) signaling pathway that contributes to metastatic behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuxiao Zheng, Feng Qi, Lu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncNAP1L6 activates MMP pathway by stabilizing the m6A-modified NAP1L2 to promote malignant progression in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Gene Ther (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41417-022-00537-3"}], "href": "https://doi.org/10.1038/s41417-022-00537-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36195720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36195720"}]}]}]}