{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nArylamine N‐acetyltransferase 1 (NAT1) is a highly polymorphic phase II enzyme that performs dual functions in human cells. First, as a key component of the NatA complex, NAT1 catalyzes the irreversible N‑terminal acetylation of nascent proteins, modulating their stability and function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, NAT1 is central to the metabolism of exogenous aromatic amines and heterocyclic compounds found in tobacco smoke, well‐cooked meats, and various xenobiotics. Structural investigations using high‐resolution crystallography have elucidated the enzyme’s substrate specificity and highlighted the essential role of a reactive active‐site cysteine, whose integrity is crucial for catalytic activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, studies indicate that under oxidative stress conditions, NAT1 activity is modulated by reactive oxygen and nitrogen species – for example, exposure to hydrogen peroxide or peroxynitrite rapidly inactivates the enzyme via oxidation of its catalytic cysteine, a process that can be reversed by reducing agents."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its intrinsic regulation, NAT1 plays a fundamental role in the biotransformation of potentially harmful xenobiotics. By catalyzing N‑, O‑, and N,O‑acetylation reactions, NAT1 can either detoxify aromatic amines or convert them into reactive intermediates that bind to DNA, thereby contributing to carcinogen activation. Several epidemiologic studies have linked NAT1 genetic variants – including the putative rapid‐acetylator allele NAT1*10 – to altered susceptibility to cancers of the colon, lung, bladder, pancreas, and even to developmental birth defects such as orofacial clefts when combined with environmental exposures like cigarette smoke or high‐temperature meat cooking."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDysregulation of NAT1 in tumor tissues further underscores its biomedical importance. In several studies, increased NAT1 expression has been documented in breast carcinomas – particularly in estrogen receptor‑positive tumors – where enhanced enzyme levels correlate with accelerated cell growth, resistance to cytotoxic drugs, and increased invasive potential. These observations suggest that NAT1 not only influences carcinogen metabolism but may also directly contribute to cancer progression, making it a promising target for therapeutic intervention. Emerging evidence from cellular studies underscores that inhibition of NAT1 activity can reduce tumor cell proliferation and invasion, while genetic polymorphisms in NAT1 are being explored as potential biomarkers for cancer risk and treatment outcome."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "24", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Thomas Arnesen, Petra Van Damme, Bogdan Polevoda, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Identification of single-nucleotide polymorphisms (SNPs) of human N-acetyltransferase genes NAT1, NAT2, AANAT, ARD1 and L1CAM in the Japanese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s100380170065"}], "href": "https://doi.org/10.1007/s100380170065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11393533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11393533"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Noureddine Atmane, Julien Dairou, Angela Paul, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Redox regulation of the human xenobiotic metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1). Reversible inactivation by hydrogen peroxide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M303813200"}], "href": "https://doi.org/10.1074/jbc.M303813200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12832400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12832400"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Julien Dairou, Noureddine Atmane, Fernando Rodrigues-Lima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Peroxynitrite irreversibly inactivates the human xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) in human breast cancer cells: a cellular and mechanistic study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M311469200"}], "href": "https://doi.org/10.1074/jbc.M311469200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14672957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14672957"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "L Le Marchand, J H Hankin, L R Wilkens, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol Biomarkers Prev (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1055-9965.EPI-05-0618"}], "href": "https://doi.org/10.1158/1055-9965.EPI-05-0618"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16434594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16434594"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Edine W Tiemersma, Ellen Kampman, H B Bueno de Mesquita, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2002)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11895912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11895912"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Shanbeh Zienolddiny, Daniele Campa, Helge Lind, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgn020"}], "href": "https://doi.org/10.1093/carcin/bgn020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18258609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18258609"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Federica Gemignani, Stefano Landi, Neonilia Szeszenia-Dabrowska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgm021"}], "href": "https://doi.org/10.1093/carcin/bgm021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17259654"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17259654"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Mariana C Stern, Laura R Johnson, Douglas A Bell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XPD codon 751 polymorphism, metabolism genes, smoking, and bladder cancer risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol Biomarkers Prev (2002)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12376500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12376500"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Edward J Lammer, Gary M Shaw, David M Iovannisci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Maternal smoking and the risk of orofacial clefts: Susceptibility with NAT1 and NAT2 polymorphisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epidemiology (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/01.ede.0000112214.33432.cc"}], "href": "https://doi.org/10.1097/01.ede.0000112214.33432.cc"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15127906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15127906"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ute Nöthlings, Jennifer F Yamamoto, Lynne R Wilkens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol Biomarkers Prev (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1055-9965.EPI-08-1218"}], "href": "https://doi.org/10.1158/1055-9965.EPI-08-1218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19549810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19549810"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Donghui Li, Li Jiao, Yanan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgi171"}], "href": "https://doi.org/10.1093/carcin/bgi171"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15987714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15987714"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Harriet Wikman, Päivi Piirilä, Christina Rosenberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N-Acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenetics (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/00008571-200204000-00007"}], "href": "https://doi.org/10.1097/00008571-200204000-00007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11927838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11927838"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Gail McKeown-Eyssen, Cornelia Baines, David E C Cole, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Epidemiol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/ije/dyh251"}], "href": "https://doi.org/10.1093/ije/dyh251"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15256524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15256524"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Shioto Suzuki, Youko Muroishi, Isao Nakanishi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Relationship between genetic polymorphisms of drug-metabolizing enzymes (CYP1A1, CYP2E1, GSTM1, and NAT2), drinking habits, histological subtypes, and p53 gene point mutations in Japanese patients with gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastroenterol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00535-003-1281-x"}], "href": "https://doi.org/10.1007/s00535-003-1281-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15064998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15064998"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "J Esteban Castelao, Jian-Min Yuan, Manuela Gago-Dominguez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Carotenoids/vitamin C and smoking-related bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.20104"}], "href": "https://doi.org/10.1002/ijc.20104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15095308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15095308"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Louise Wideroff, Thomas L Vaughan, Federico M Farin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Detect Prev (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cdp.2007.03.004"}], "href": "https://doi.org/10.1016/j.cdp.2007.03.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17646057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17646057"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Olga L van der Hel, Petra H M Peeters, David W Hein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAT2 slow acetylation and GSTM1 null genotypes may increase postmenopausal breast cancer risk in long-term smoking women."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenetics (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/00008571-200307000-00005"}], "href": "https://doi.org/10.1097/00008571-200307000-00005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12835615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12835615"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "M Krajinovic, P Ghadirian, C Richer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic susceptibility to breast cancer in French-Canadians: role of carcinogen-metabolizing enzymes and gene-environment interactions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1097-0215(200102)9999:9999"}, {"type": "a", "children": [{"type": "t", "text": "::aid-ijc1184"}], "href": "::aid-ijc1184"}, {"type": "t", "text": "3.0.co;2-h"}], "href": "https://doi.org/10.1002/1097-0215(200102"}, {"type": "t", "text": "9999:9999"}, {"type": "a", "children": [{"type": "t", "text": "::aid-ijc1184"}], "href": "::aid-ijc1184"}, {"type": "t", "text": "3.0.co;2-h) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11291049"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11291049"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Paul J Adam, Joanne Berry, Julie A Loader, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arylamine N-acetyltransferase-1 is highly expressed in breast cancers and conveys enhanced growth and resistance to etoposide in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2003)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14517345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14517345"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Jacky M Tiang, Neville J Butcher, Rodney F Minchin "}, {"type": "b", "children": [{"type": "t", "text": "Small molecule inhibition of arylamine N-acetyltransferase Type I inhibits proliferation and invasiveness of MDA-MB-231 breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2010.01.087"}], "href": "https://doi.org/10.1016/j.bbrc.2010.01.087"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20100460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20100460"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Suleeporn Sangrajrang, Yasunori Sato, Hiromi Sakamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-010-0804-4"}], "href": "https://doi.org/10.1007/s10549-010-0804-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20180013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20180013"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Larissa Wakefield, James Robinson, Hilary Long, et al. 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