{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNoBody (NBDY) is a 7‐kDa microprotein produced from a small open reading frame that functions as a novel modulator of mRNA turnover. It physically interacts with mRNA decapping proteins—the enzymes responsible for removing the protective 5′ cap from mRNAs—thereby influencing both general mRNA decay and nonsense-mediated decay pathways. Moreover, NoBody localizes to P-bodies, the cytoplasmic RNA–protein granules associated with mRNA degradation, and its cellular abundance inversely correlates with P-body number as well as the steady-state levels of specific mRNA substrates."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe discovery of NoBody adds to the growing body of evidence that non-annotated smORFs can encode functional microproteins, challenging the traditional view of long noncoding RNAs solely as RNA molecules. In the context of human diseases such as pancreatic cancer, long noncoding RNAs have been implicated in myriad cellular processes even though many of their biological roles remain obscure."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have underscored the importance of delineating the contributions of both the RNA transcripts and their encoded microproteins. Studies now suggest that the regulatory impact on gene expression might result from either the microprotein or the lncRNA itself, or a combination of both, prompting further analysis of their functional interplay in diverse diseases. This emerging paradigm reinforces the significance of NoBody as a bona fide regulator of mRNA decay pathways and as a representative of the functional potential harbored by previously overlooked smORF-encoded peptides."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nadia G D'Lima, Jiao Ma, Lauren Winkler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A human microprotein that interacts with the mRNA decapping complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Chem Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nchembio.2249"}], "href": "https://doi.org/10.1038/nchembio.2249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27918561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27918561"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hongjun Zhai, Xinwu Zhang, Xiaoli Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-coding RNA LINC01420 Contributes to Pancreatic Cancer Progression Through Targeting KRAS Proto-oncogene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-019-05829-7"}], "href": "https://doi.org/10.1007/s10620-019-05829-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31562613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31562613"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Daria O Konina, Alexandra Yu Filatova, Mikhail Yu Skoblov "}, {"type": "b", "children": [{"type": "t", "text": "LINC01420 RNA structure and influence on cell physiology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-019-5538-z"}], "href": "https://doi.org/10.1186/s12864-019-5538-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32039714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32039714"}]}]}]}