{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNCF1, which encodes the cytosolic p47^phox subunit of the phagocyte NADPH oxidase, is central to the regulated generation of reactive oxygen species (ROS) in host defense. By undergoing stimulus‐induced phosphorylation, p47^phox changes conformation to expose its tandem SH3 domains, permitting binding to the proline‐rich region of p22^phox and thereby initiating the orderly assembly of the active oxidase complex. Multiple studies have demonstrated that signaling pathways—including those mediated by MAP kinases, IRAK‐4, and other kinases—and external triggers such as Toll‐like receptor ligands or growth factors control the phosphorylation status and membrane translocation of p47^phox. These events are critical for the rapid and spatially controlled ROS production observed in neutrophils, monocytes, and endothelial cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAlterations in NCF1 function—whether by inherited mutations, copy‐number variations or single nucleotide polymorphisms—profoundly impact human disease. Defective p47^phox causes chronic granulomatous disease (CGD) by impeding NADPH oxidase assembly and consequent ROS‐mediated microbial killing, while specific missense variants (such as p.Arg90His) predispose to autoimmune disorders including systemic lupus erythematosus, rheumatoid arthritis and the antiphospholipid syndrome. In parallel, aberrant regulation of p47^phox has been linked to oxidative stress in contexts as varied as diabetic complications, vascular endothelial dysfunction, and even neurodegeneration. These findings underscore that precise control of NADPH oxidase activation via NCF1 is essential not only for efficient pathogen clearance but also for the maintenance of immune and vascular homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNCF1 also functions within broader regulatory networks through interactions with diverse proteins such as protein disulfide isomerase, cytosolic phospholipase A2, PAD4 and Tks adaptors. These interactions modulate p47^phox phosphorylation and its incorporation into the NADPH oxidase complex in settings ranging from hyperoxia‐induced lung injury and tumor cell migration to TLR8‐dependent neutrophil priming. Such cross‐talk influences not only the magnitude of the oxidative burst but also downstream inflammatory and tissue‐remodeling processes. The therapeutic targeting of these interactions, or direct modulation of p47^phox function, holds promise for ameliorating pathological oxidative stress in conditions as varied as vascular disease, chronic inflammation and cancer metastasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "26", "end_ref": "39"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kenji Ogura, Ikuo Nobuhisa, Satoru Yuzawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NMR solution structure of the tandem Src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M505193200"}], "href": "https://doi.org/10.1074/jbc.M505193200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16326715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16326715"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Pham My-Chan Dang, Allan Stensballe, Tarek Boussetta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A specific p47phox -serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI27544"}], "href": "https://doi.org/10.1172/JCI27544"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16778989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16778989"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sandrine Pacquelet, Jennifer L Johnson, Beverly A Ellis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cross-talk between IRAK-4 and the NADPH oxidase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20061184"}], "href": "https://doi.org/10.1042/BJ20061184"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17217339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17217339"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Rachel P Wilkie, Margret C M Vissers, Mike Dragunow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A functional NADPH oxidase prevents caspase involvement in the clearance of phagocytic neutrophils."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Infect Immun (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/IAI.01984-06"}], "href": "https://doi.org/10.1128/IAI.01984-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17438039"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17438039"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Anthony J Donato, Iratxe Eskurza, Annemarie E Silver, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.RES.0000269183.13937.e8"}], "href": "https://doi.org/10.1161/01.RES.0000269183.13937.e8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17478731"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17478731"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Maria Annunziata Carluccio, Maria Assunta Ancora, Marika Massaro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Homocysteine induces VCAM-1 gene expression through NF-kappaB and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Heart Circ Physiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpheart.00432.2007"}], "href": "https://doi.org/10.1152/ajpheart.00432.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17586618"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17586618"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chul-Su Yang, Dong-Min Shin, Hye-Mi Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Microbiol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1462-5822.2007.01081.x"}], "href": "https://doi.org/10.1111/j.1462-5822.2007.01081.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18028450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18028450"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Anselm T Bäumer, Henrik Ten Freyhaus, Heinrich Sauer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M704997200"}], "href": "https://doi.org/10.1074/jbc.M704997200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18070887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18070887"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Kazuhiro Omori, Taisuke Ohira, Yushi Uchida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.1207832"}], "href": "https://doi.org/10.1189/jlb.1207832"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18390927"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18390927"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Anthony Lemarie, Emilie Bourdonnay, Claudie Morzadec, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inorganic arsenic activates reduced NADPH oxidase in human primary macrophages through a Rho kinase/p38 kinase pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.180.9.6010"}], "href": "https://doi.org/10.4049/jimmunol.180.9.6010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18424721"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18424721"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Caroline Kannengiesser, Bénédicte Gérard, Jamel El Benna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular epidemiology of chronic granulomatous disease in a series of 80 kindreds: identification of 31 novel mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.20820"}], "href": "https://doi.org/10.1002/humu.20820"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18546332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18546332"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Zeev Shmelzer, Maria Karter, Miriam Eisenstein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cytosolic phospholipase A2alpha is targeted to the p47phox-PX domain of the assembled NADPH oxidase via a novel binding site in its C2 domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M804674200"}], "href": "https://doi.org/10.1074/jbc.M804674200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18765662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18765662"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Katja Lehmann, Jörg P Müller, Bernhard Schlott, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PI3Kgamma controls oxidative bursts in neutrophils via interactions with PKCalpha and p47phox."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20081268"}], "href": "https://doi.org/10.1042/BJ20081268"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18983267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18983267"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Peter V Usatyuk, Irina A Gorshkova, Donghong He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phospholipase D-mediated activation of IQGAP1 through Rac1 regulates hyperoxia-induced p47phox translocation and reactive oxygen species generation in lung endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.005439"}], "href": "https://doi.org/10.1074/jbc.M109.005439"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19366706"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19366706"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Annadora J Bruce-Keller, Sunita Gupta, Taryn E Parrino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NOX activity is increased in mild cognitive impairment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Antioxid Redox Signal (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/ars.2009.2823"}], "href": "https://doi.org/10.1089/ars.2009.2823"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19929442"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19929442"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Dirk Roos, Douglas B Kuhns, Anne Maddalena, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hematologically important mutations: the autosomal recessive forms of chronic granulomatous disease (second update)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Cells Mol Dis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bcmd.2010.01.009"}], "href": "https://doi.org/10.1016/j.bcmd.2010.01.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20167518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20167518"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Felix Meissner, Reinhard A Seger, Despina Moshous, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2010-01-264218"}], "href": "https://doi.org/10.1182/blood-2010-01-264218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20495074"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20495074"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Julien Marcoux, Petr Man, Isabelle Petit-Haertlein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p47phox molecular activation for assembly of the neutrophil NADPH oxidase complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.139824"}], "href": "https://doi.org/10.1074/jbc.M110.139824"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20592030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20592030"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Lina M Olsson, Annika Nerstedt, Anna-Karin Lindqvist, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Copy number variation of the gene NCF1 is associated with rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Antioxid Redox Signal (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/ars.2011.4013"}], "href": "https://doi.org/10.1089/ars.2011.4013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21728841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21728841"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Fatemeh Fattahi, Mohsen Badalzadeh, Leyla Sedighipour, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inheritance pattern and clinical aspects of 93 Iranian patients with chronic granulomatous disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10875-011-9567-x"}], "href": "https://doi.org/10.1007/s10875-011-9567-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21789723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21789723"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Antonio Marcus de A Paes, Sidney Veríssimo-Filho, Luciana Lopes Guimarães, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein disulfide isomerase redox-dependent association with p47(phox): evidence for an organizer role in leukocyte NADPH oxidase activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.0610324"}], "href": "https://doi.org/10.1189/jlb.0610324"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21791598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21791598"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Jung-Mi Yun, Alexander Chien, Ishwarlal Jialal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Nutr Biochem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jnutbio.2011.03.012"}], "href": "https://doi.org/10.1016/j.jnutbio.2011.03.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21813271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21813271"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Ismail Syed, Chandrashekara N Kyathanahalli, Bhavaani Jayaram, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db11-0809"}], "href": "https://doi.org/10.2337/db11-0809"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21911753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21911753"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Takehiko Ueyama, Junya Nakakita, Takashi Nakamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcγ receptor (FcγR)-mediated phagocytosis: mechanism for acquisition of p40(phox) phosphatidylinositol 3-phosphate (PI(3)P) binding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.237289"}], "href": "https://doi.org/10.1074/jbc.M111.237289"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21956105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21956105"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Peter V Usatyuk, Patrick A Singleton, Srikanth Pendyala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel role for non-muscle myosin light chain kinase (MLCK) in hyperoxia-induced recruitment of cytoskeletal proteins, NADPH oxidase activation, and reactive oxygen species generation in lung endothelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.294546"}], "href": "https://doi.org/10.1074/jbc.M111.294546"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22219181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22219181"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Astghik Hayrapetyan, Paula C D Dencher, Karin van Leeuwen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Different unequal cross-over events between NCF1 and its pseudogenes in autosomal p47(phox)-deficient chronic granulomatous disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2013.05.001"}], "href": "https://doi.org/10.1016/j.bbadis.2013.05.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23688784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23688784"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Margarita Hurtado-Nedelec, Marie-José Csillag-Grange, Tarek Boussetta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased reactive oxygen species production and p47phox phosphorylation in neutrophils from myeloproliferative disorders patients with JAK2 (V617F) mutation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.2012.082560"}], "href": "https://doi.org/10.3324/haematol.2012.082560"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23975181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23975181"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Maria Raptaki, Ioanna Varela, Kleopatra Spanou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chronic granulomatous disease: a 25-year patient registry based on a multistep diagnostic procedure, from the referral center for primary immunodeficiencies in Greece."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Immunol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10875-013-9940-z"}], "href": "https://doi.org/10.1007/s10875-013-9940-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24081483"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24081483"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Beth A Kozel, Joshua R Danback, Jessica L Waxler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Williams syndrome predisposes to vascular stiffness modified by antihypertensive use and copy number changes in NCF1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertension (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/HYPERTENSIONAHA.113.02087"}], "href": "https://doi.org/10.1161/HYPERTENSIONAHA.113.02087"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24126171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24126171"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Karama Makni-Maalej, Viviana Marzaioli, Tarek Boussetta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.2A1214-623R"}], "href": "https://doi.org/10.1189/jlb.2A1214-623R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25877926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25877926"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Ram Prasad, John C Kappes, Santosh K Katiyar "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of NADPH oxidase 1 activity and blocking the binding of cytosolic and membrane-bound proteins by honokiol inhibit migratory potential of melanoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.6860"}], "href": "https://doi.org/10.18632/oncotarget.6860"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26760964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26760964"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Anantha Harijith, Srikanth Pendyala, David L Ebenezer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Lung Cell Mol Physiol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajplung.00447.2015"}], "href": "https://doi.org/10.1152/ajplung.00447.2015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27343196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27343196"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Justin D La Favor, Gabriel S Dubis, Huimin Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microvascular Endothelial Dysfunction in Sedentary, Obese Humans Is Mediated by NADPH Oxidase: Influence of Exercise Training."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.116.308339"}], "href": "https://doi.org/10.1161/ATVBAHA.116.308339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27765769"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27765769"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Jian Zhao, Jianyang Ma, Yun Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.3782"}], "href": "https://doi.org/10.1038/ng.3782"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28135245"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28135245"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Lina M Olsson, Åsa C Johansson, Birgitta Gullstrand, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A single nucleotide polymorphism in the "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "NCF1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " gene leading to reduced oxidative burst is associated with systemic lupus erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Rheum Dis (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/annrheumdis-2017-211287"}], "href": "https://doi.org/10.1136/annrheumdis-2017-211287"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28606963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28606963"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Priyanka Saini, Sara A Courtneidge "}, {"type": "b", "children": [{"type": "t", "text": "Tks adaptor proteins at a glance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.203661"}], "href": "https://doi.org/10.1242/jcs.203661"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29311151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29311151"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Yebin Zhou, Ling-Ling An, Raghothama Chaerkady, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for a direct link between PAD4-mediated citrullination and the oxidative burst in human neutrophils."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-33385-z"}], "href": "https://doi.org/10.1038/s41598-018-33385-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30323221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30323221"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Marcela Gimenez, Sidney Veríssimo-Filho, Ilka Wittig, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "phox"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " in Vascular Smooth Muscle Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.118.311038"}], "href": "https://doi.org/10.1161/ATVBAHA.118.311038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30580571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30580571"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Petrus Linge, Sabine Arve, Lina M Olsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Rheum Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/annrheumdis-2019-215820"}], "href": "https://doi.org/10.1136/annrheumdis-2019-215820"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31704719"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31704719"}]}]}]}