NCF2 Gene

HGNC Family	Tetratricopeptide repeat domain containing (TTC)
Name	neutrophil cytosolic factor 2
Description	This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNCF2, which encodes the cytosolic p67phox protein, is a critical regulatory subunit of the NADPH oxidase complex that drives the production of reactive oxygen species (ROS) in phagocytes and other cell types. p67phox plays an essential role in the assembly and activation of the oxidase by interacting with other cytosolic subunits (such as p47phox) and small GTPases (e.g., Rac), thereby facilitating the recruitment to membrane‐bound partners such as cytochrome b558 (gp91phox/p22phox) and stabilizing the electron‐transfer apparatus. Several studies using reconstituted cell systems, biochemical assays, and structural analyses have demonstrated that p67phox undergoes regulated translocation—from the cytosol to specific subcellular locales—and engages in multiple protein–protein interactions. For example, modifications induced by arachidonic acid and phosphorylation events catalyzed by upstream kinases (or even modulation by additional effectors like MRP8/MRP14 and PAD4) fine‐tune the binding efficiency of p67phox with its partners, ensuring both proper assembly and optimal oxidase activity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic variations in NCF2 have been robustly associated with human immunological disorders and inflammatory diseases. Mutations—ranging from non‐synonymous coding changes (for instance, the H389Q variant) to deletions affecting critical domains—can impair the ability of p67phox to interact with other NADPH oxidase components, resulting in reduced ROS generation. Such defective oxidase function underlies conditions like chronic granulomatous disease (CGD) and has also been implicated in the susceptibility to autoimmune disorders such as systemic lupus erythematosus (SLE). Multi‐ethnic studies and molecular modeling have revealed complex allelic heterogeneity within NCF2 that contributes to disease risk and severity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its functional role within the oxidase complex, NCF2 expression is under tight transcriptional and post‐transcriptional control. Detailed promoter analyses and studies of alternative 5′-untranslated region (UTR) usage have uncovered regulatory elements that mediate both basal and inducible expression of NCF2. Factors such as p53 have been shown to bind directly to the NCF2 promoter, while noncoding RNAs—including long noncoding RNA species—can modulate its transcriptional output in pathological contexts like cancer metastasis and cardiovascular disease. These regulatory mechanisms not only impact ROS production and redox‐sensitive signaling pathways but also hold promise as biomarkers for noninvasive disease stratification."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Karine Lapouge, Susan J M Smith, Yvonne Groemping, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Architecture of the p40-p47-p67phox complex in the resting state of the NADPH oxidase. A central role for p67phox."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112065200"}], "href": "https://doi.org/10.1074/jbc.M112065200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11796733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11796733"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Marianne O Price, Linda C McPhail, J David Lambeth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.v99.8.2653"}], "href": "https://doi.org/10.1182/blood.v99.8.2653"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11929750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11929750"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaoxian Zhao, Erik A Bey, Frans B Wientjes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cytosolic phospholipase A2 (cPLA2) regulation of human monocyte NADPH oxidase activity. cPLA2 affects translocation but not phosphorylation of p67(phox) and p47(phox)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M203630200"}], "href": "https://doi.org/10.1074/jbc.M203630200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12101222"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12101222"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sylvie Berthier, Marie-Helene Paclet, Sandra Lerouge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Changing the conformation state of cytochrome b558 initiates NADPH oxidase activation: MRP8/MRP14 regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M209755200"}], "href": "https://doi.org/10.1074/jbc.M209755200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12719414"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12719414"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Wenyu Ming, Shijun Li, Daniel D Billadeau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00985-06"}], "href": "https://doi.org/10.1128/MCB.00985-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17060455"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17060455"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Anthony Lemarie, Emilie Bourdonnay, Claudie Morzadec, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inorganic arsenic activates reduced NADPH oxidase in human primary macrophages through a Rho kinase/p38 kinase pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.180.9.6010"}], "href": "https://doi.org/10.4049/jimmunol.180.9.6010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18424721"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18424721"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Satoru Yuzawa, Kei Miyano, Kazuya Honbou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The domain organization of p67 phox, a protein required for activation of the superoxide-producing NADPH oxidase in phagocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Innate Immun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000235656"}], "href": "https://doi.org/10.1159/000235656"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20375610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20375610"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yuichi Maehara, Kei Miyano, Satoru Yuzawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A conserved region between the TPR and activation domains of p67phox participates in activation of the phagocyte NADPH oxidase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.161166"}], "href": "https://doi.org/10.1074/jbc.M110.161166"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20679349"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20679349"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Iris Dahan, Susan M E Smith, Edgar Pick "}, {"type": "b", "children": [{"type": "t", "text": "A Cys-Gly-Cys triad in the dehydrogenase region of Nox2 plays a key role in the interaction with p67phox."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.4A0315-107R"}], "href": "https://doi.org/10.1189/jlb.4A0315-107R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26160850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26160850"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yebin Zhou, Ling-Ling An, Raghothama Chaerkady, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for a direct link between PAD4-mediated citrullination and the oxidative burst in human neutrophils."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-33385-z"}], "href": "https://doi.org/10.1038/s41598-018-33385-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30323221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30323221"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Marcus Gentsch, Aneta Kaczmarczyk, Karin van Leeuwen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alu-repeat-induced deletions within the NCF2 gene causing p67-phox-deficient chronic granulomatous disease (CGD)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.21156"}], "href": "https://doi.org/10.1002/humu.21156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19953534"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19953534"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Dirk Roos, Douglas B Kuhns, Anne Maddalena, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hematologically important mutations: the autosomal recessive forms of chronic granulomatous disease (second update)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Cells Mol Dis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bcmd.2010.01.009"}], "href": "https://doi.org/10.1016/j.bcmd.2010.01.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20167518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20167518"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Bo Yu, Yuewen Chen, Qi Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The association between single-nucleotide polymorphisms of NCF2 and systemic lupus erythematosus in Chinese mainland population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Rheumatol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10067-010-1567-3"}], "href": "https://doi.org/10.1007/s10067-010-1567-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20842512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20842512"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Deborah S Cunninghame Graham, David L Morris, Tushar R Bhangale, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1002341"}], "href": "https://doi.org/10.1371/journal.pgen.1002341"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22046141"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22046141"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Chaim O Jacob, Miriam Eisenstein, Mary C Dinauer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1113251108"}], "href": "https://doi.org/10.1073/pnas.1113251108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22203994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22203994"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Xana Kim-Howard, Celi Sun, Julio E Molineros, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddt532"}], "href": "https://doi.org/10.1093/hmg/ddt532"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24163247"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24163247"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Laila Ait Baba, Fatima Ailal, Naima El Hafidi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chronic granulomatous disease in Morocco: genetic, immunological, and clinical features of 12 patients from 10 kindreds."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10875-014-9997-3"}], "href": "https://doi.org/10.1007/s10875-014-9997-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24596025"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24596025"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Don L Armstrong, Miriam Eisenstein, Raphael Zidovetzki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systemic lupus erythematosus-associated neutrophil cytosolic factor 2 mutation affects the structure of NADPH oxidase complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.639021"}], "href": "https://doi.org/10.1074/jbc.M115.639021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25795782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25795782"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "S L Li, A J Valente, L Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional regulation of the p67phox gene: role of AP-1 in concert with myeloid-specific transcription factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M106111200"}], "href": "https://doi.org/10.1074/jbc.M106111200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11483614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11483614"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Katherine A Gauss, Peggy L Bunger, Matthew A Crawford, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variants of the 5'-untranslated region of human NCF2: expression and translational efficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2005.09.012"}], "href": "https://doi.org/10.1016/j.gene.2005.09.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16310324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16310324"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Dafne Italiano, Anna Maria Lena, Gerry Melino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of NCF2/p67phox as a novel p53 target gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.22853"}], "href": "https://doi.org/10.4161/cc.22853"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23187810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23187810"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Xian-Gang Mo, Wei Liu, Yao Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NCF2, MYO1F, S1PR4, and FCN1 as potential noninvasive diagnostic biomarkers in patients with obstructive coronary artery: A weighted gene co-expression network analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29128"}], "href": "https://doi.org/10.1002/jcb.29128"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31245869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31245869"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Jinbo Xie, Hui Zhang, Keyi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "M6A-mediated-upregulation of lncRNA BLACAT3 promotes bladder cancer angiogenesis and hematogenous metastasis through YBX3 nuclear shuttling and enhancing NCF2 transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-023-02814-3"}], "href": "https://doi.org/10.1038/s41388-023-02814-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37612524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37612524"}]}]}]}
Synonyms	NOXA2, P67PHOX, P67-PHOX, NCF-2
Proteins	NCF2_HUMAN
NCBI Gene ID	4688
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NCF2 has 8,327 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 131 datasets.

Click the + buttons to view associations for NCF2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NCF2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NCF2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NCF2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NCF2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NCF2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NCF2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving NCF2 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NCF2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NCF2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NCF2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of NCF2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NCF2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NCF2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with NCF2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NCF2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NCF2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NCF2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with NCF2 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with NCF2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NCF2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NCF2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NCF2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing NCF2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing NCF2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NCF2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NCF2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NCF2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NCF2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NCF2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NCF2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by NCF2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving NCF2 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving NCF2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with NCF2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NCF2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NCF2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NCF2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NCF2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for NCF2 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NCF2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NCF2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.