{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that NCK1‐DT (also known as NCK1‐AS1) functions as a potent oncogenic long non‐coding RNA in several solid tumors. In cervical cancer, NCK1‐DT is transcriptionally activated—via SP1 binding—and acts as a molecular sponge for miR‑6857, thereby de‐repressing CDK1/6 to promote cell proliferation, invasion, and tumor progression. Similarly, in ovarian cancer, NCK1‐DT not only competitively binds miR‑137 to elevate NCK1 mRNA expression but also stabilizes the NCK1 protein by blocking c‐Cbl‐induced degradation, contributing to increased cell proliferation, migration, and chemoresistance. In glioma, enhanced NCK1‐DT expression facilitates temozolomide resistance by modulating the miR‑137/TRIM24 axis, while elevated levels in hepatocellular carcinoma further underscore its tumor‐promoting role."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn lung malignancies such as non‐small cell lung cancer (NSCLC) and lung squamous cell carcinoma, NCK1‐DT is significantly upregulated and correlates with aggressive disease features. Its oncogenic role in these contexts involves the modulation of microRNA networks—specifically, by sponging miR‑512‑5p and miR‑361‑5p—to indirectly regulate downstream targets such as NCK1 and ADAM10, thereby driving cell proliferation, migration, invasion, and epithelial‑mesenchymal transition. These findings highlight the therapeutic potential of targeting NCK1‐DT in lung cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, in esophageal squamous cell carcinoma (ESCC), NCK1‐DT promotes oncogenesis by binding to miR‑133b, which leads to the upregulation of ENPEP and thereby enhances cell proliferation, invasion, and migration. Comprehensive reviews further emphasize that aberrant NCK1‐DT expression is a common denominator across various malignancies and even in non‐cancerous conditions such as atherosclerosis, positioning it as a promising diagnostic marker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Haiyu Li, Yongqin Jia, Junning Cheng, et al. 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