| Name | NADH dehydrogenase subunit 4 |
| Description | Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of mitochondrial inner membrane and respiratory chain complex I. Implicated in Leber hereditary optic neuropathy; Parkinson's disease; macular degeneration; and schizophrenia. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Mar 2025] |
| NCBI Gene ID | 4538 |
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| Predicted Functions |
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| Expression in Tissues and Cell Lines |
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ND4 has 185 functional associations with biological entities spanning 4 categories (functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 7 datasets.
Click the + buttons to view associations for ND4 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ND4 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| CM4AI U2OS Cell Map Protein Localization Assemblies | assemblies containing ND4 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset. | |
| DGIdb Drug Targets 2026 | interacting drugs for ND4 protein from the DGIdb Drug Targets 2026 dataset. | |
| KEGG Pathways 2026 | pathways involving ND4 protein from the KEGG Pathways 2026 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving ND4 protein from the Wikipathways PFOCR 2024 dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of ND4 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| WikiPathways Pathways 2024 | pathways involving ND4 protein from the WikiPathways Pathways 2024 dataset. | |
