NEDD4 Gene

Name neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
Description This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNEDD4, as a member of the HECT‐domain E3 ubiquitin ligase family, plays a pivotal role in tumorigenesis by modulating the stability of key tumor suppressors and oncoproteins. In cancer cells, enhanced expression of NEDD4‐1 induces polyubiquitination and degradation of the phosphatase PTEN, thereby lowering PTEN levels and promoting cellular transformation and tumor progression. Moreover, aberrant NEDD4 activity has been linked to glioma development through FoxM1B‐mediated NEDD4‐1 upregulation, and genetic studies associate NEDD4 polymorphisms with fibroproliferative disorders such as keloids. NEDD4 also modifies other tumor‐suppressive regulators including Beclin 1, further underscoring its role in reprogramming signaling pathways that favor neoplastic growth."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn various cell types, NEDD4 and its close paralogue NEDD4‐2 regulate the trafficking, membrane expression, and signaling of critical receptors and ion channels. For instance, NEDD4‐2 negatively regulates the cardiac Na⁺ channel Na_v1.5 and neuronal Na⁺ channels via binding to PY motifs, whereas it modulates the epithelial Na⁺ channel (ENaC) in epithelia—processes that influence cellular excitability and fluid homeostasis. In addition, NEDD4 facilitates beta₂‐adrenergic receptor ubiquitination in cooperation with adaptor proteins, controls dopamine transporter endocytosis following PKC activation, and catalyzes non‐canonical ubiquitination of fibroblast growth factor receptor 1 (FGFR1), hence modulating receptor signaling and downstream Akt trafficking. Such multifaceted regulatory roles highlight NEDD4’s central action in receptor turnover and signal termination."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNEDD4 functions as a key mediator in cellular stress responses. In conditions of oxidative or genotoxic stress, its expression is upregulated to promote ubiquitination events that enable appropriate turnover of damaged proteins. For example, upon erastin‐treatment—a ferroptosis activator—NEDD4 is induced to ubiquitinate voltage‐dependent anion channels, thereby modulating mitochondrial homeostasis. In response to UV‐induced DNA damage, NEDD4 associates with RNA polymerase II to target it for ubiquitin‐dependent degradation, a process central to the DNA damage response. In these settings, calcium signaling can relieve intrinsic autoinhibition of NEDD4, further fine‐tuning its ubiquitination activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}, {"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the nervous system, NEDD4 contributes to protein quality control and synaptic plasticity. It promotes the ubiquitination of α‐synuclein through K63‐linked chains, facilitating its lysosomal clearance—a mechanism that may protect against Parkinson disease. Similarly, NEDD4‐mediated ubiquitination of AMPA receptors controls their internalization and stability, thereby modulating excitatory synaptic transmission. These regulatory mechanisms are crucial for maintaining neuronal homeostasis and preventing proteotoxic stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNEDD4 is also co‐opted by viruses to facilitate different stages of their life cycles. In Ebola virus infection, NEDD4 ubiquitinates the VP40 matrix protein to promote virus‐like particle budding—a process counteracted by antiviral molecules such as ISG15. Retroviruses including HTLV‐1 hijack NEDD4‐1 for Gag ubiquitination to ensure efficient egress, while hepatitis B virus employs NEDD4 to orchestrate its assembly and release. Moreover, NEDD4‐dependent ubiquitination of IFITM3 modulates its turnover, thereby impacting host resistance to influenza virus infection."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther insights into the mechanistic aspects of NEDD4 function have emerged from structural and developmental studies. High‐resolution analyses of the Ub‐loaded NEDD4 elucidate a sequential addition mechanism governed by Lys63‐specific polyubiquitin chain formation, while intramolecular linker regions have been shown to mediate autoinhibition that can be relieved upon post‐translational modifications. In addition, NEDD4 (and its paralogue NEDD4L) regulates developmental processes by targeting receptors such as the LGR family in intestinal stem cells; such regulation of receptor turnover is critical for controlling stem cell priming and may affect tumor predisposition. Moreover, in lung cancer cells, NEDD4 influences EGFR‐dependent migration, emphasizing its diverse roles in both intracellular trafficking and cell motility."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "25", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xinjiang Wang, Lloyd C Trotman, Theresa Koppie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2006.11.039"}], "href": "https://doi.org/10.1016/j.cell.2006.11.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17218260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17218260"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mitsuko Nakashima, Suyoun Chung, Atsushi Takahashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.645"}], "href": "https://doi.org/10.1038/ng.645"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20711176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20711176"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Harald W Platta, Hilde Abrahamsen, Sigrid B Thoresen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20111424"}], "href": "https://doi.org/10.1042/BJ20111424"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21936852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21936852"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nicola Amodio, Marianna Scrima, Lucia Palaia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2010.091075"}], "href": "https://doi.org/10.2353/ajpath.2010.091075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20889565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20889565"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Natasha Anne Boase, Sharad Kumar "}, {"type": "b", "children": [{"type": "t", "text": "NEDD4: The founding member of a family of ubiquitin-protein ligases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2014.12.020"}], "href": "https://doi.org/10.1016/j.gene.2014.12.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25527121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25527121"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Bingbing Dai, Russell O Pieper, Dawei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-3909"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-3909"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20332230"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20332230"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Miguel X van Bemmelen, Jean-Sébastien Rougier, Bruno Gavillet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.RES.0000136816.05109.89"}], "href": "https://doi.org/10.1161/01.RES.0000136816.05109.89"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15217910"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15217910"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sudha K Shenoy, Kunhong Xiao, Vidya Venkataramanan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M709668200"}], "href": "https://doi.org/10.1074/jbc.M709668200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18544533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18544533"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Tatiana Sorkina, Manuel Miranda, Kalen R Dionne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA interference screen reveals an essential role of Nedd4-2 in dopamine transporter ubiquitination and endocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1301-06.2006"}], "href": "https://doi.org/10.1523/JNEUROSCI.1301-06.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16885233"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16885233"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Peter M Snyder, Jennifer C Steines, Diane R Olson "}, {"type": "b", "children": [{"type": "t", "text": "Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNA interference."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M312477200"}], "href": "https://doi.org/10.1074/jbc.M312477200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14645220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14645220"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jean-Sébastien Rougier, Miguel X van Bemmelen, M Christine Bruce, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00460.2004"}], "href": "https://doi.org/10.1152/ajpcell.00460.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15548568"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15548568"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Joseph Murdaca, Caroline Treins, Marie-Noëlle Monthouël-Kartmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M311802200"}], "href": "https://doi.org/10.1074/jbc.M311802200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15060076"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15060076"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jian Wang, Qisheng Peng, Qiong Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Calcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.086405"}], "href": "https://doi.org/10.1074/jbc.M109.086405"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20172859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20172859"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Chuan-Dong Fan, Michelle A Lum, Chao Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.416339"}], "href": "https://doi.org/10.1074/jbc.M112.416339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23195959"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23195959"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Avinash Persaud, Philipp Alberts, Sara Mari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2005290"}], "href": "https://doi.org/10.1126/scisignal.2005290"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25292214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25292214"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yongfei Yang, Meiying Luo, Kexin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-14324-x"}], "href": "https://doi.org/10.1038/s41467-020-14324-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31974380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31974380"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Roy Anindya, Ozan Aygün, Jesper Q Svejstrup "}, {"type": "b", "children": [{"type": "t", "text": "Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2007.10.008"}], "href": "https://doi.org/10.1016/j.molcel.2007.10.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17996703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17996703"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "George K Tofaris, Hyoung Tae Kim, Raphael Hourez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1109356108"}], "href": "https://doi.org/10.1073/pnas.1109356108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21953697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21953697"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Amy Lin, Qingming Hou, Larissa Jarzylo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1471-4159.2011.07221.x"}], "href": "https://doi.org/10.1111/j.1471-4159.2011.07221.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21338354"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21338354"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Atsushi Okumura, Paula M Pitha, Ronald N Harty "}, {"type": "b", "children": [{"type": "t", "text": "ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0710629105"}], "href": "https://doi.org/10.1073/pnas.0710629105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18305167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18305167"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Oxana A Malakhova, Dong-Er Zhang "}, {"type": "b", "children": [{"type": "t", "text": "ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C800030200"}], "href": "https://doi.org/10.1074/jbc.C800030200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18287095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18287095"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Vincent Blot, Fabien Perugi, Bernard Gay, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.01095"}], "href": "https://doi.org/10.1242/jcs.01095"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15126635"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15126635"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Nicholas M Chesarino, Temet M McMichael, Jacob S Yount "}, {"type": "b", "children": [{"type": "t", "text": "E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1005095"}], "href": "https://doi.org/10.1371/journal.ppat.1005095"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26263374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26263374"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Martina Rost, Sylvia Mann, Carsten Lambert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gamma-adaptin, a novel ubiquitin-interacting adaptor, and Nedd4 ubiquitin ligase control hepatitis B virus maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M603517200"}], "href": "https://doi.org/10.1074/jbc.M603517200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16867982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16867982"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Elena Maspero, Eleonora Valentini, Sara Mari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.2566"}], "href": "https://doi.org/10.1038/nsmb.2566"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23644597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23644597"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Youngshil Pak, Wioletta K Glowacka, M Christine Bruce, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200603001"}], "href": "https://doi.org/10.1083/jcb.200603001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17116753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17116753"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Zan Chen, Hanjie Jiang, Wei Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Tunable Brake for HECT Ubiquitin Ligases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2017.03.020"}], "href": "https://doi.org/10.1016/j.molcel.2017.03.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28475870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28475870"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Zhi-Wei Wang, Xiaoli Hu, Miaomiao Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEDD4 E3 ligase: Functions and mechanism in human cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Semin Cancer Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.semcancer.2020.03.006"}], "href": "https://doi.org/10.1016/j.semcancer.2020.03.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32171886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32171886"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Sara Mari, Natalia Ruetalo, Elena Maspero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural and functional framework for the autoinhibition of Nedd4-family ubiquitin ligases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2014.09.006"}], "href": "https://doi.org/10.1016/j.str.2014.09.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25438670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25438670"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Laura Novellasdemunt, Anna Kucharska, Cara Jamieson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.2019102771"}], "href": "https://doi.org/10.15252/embj.2019102771"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31867777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31867777"}]}]}]}
Synonyms NEDD4-1, RPF1
Proteins NEDD4_HUMAN
NCBI Gene ID 4734
API
Download Associations
Predicted Functions View NEDD4's ARCHS4 Predicted Functions.
Co-expressed Genes View NEDD4's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View NEDD4's ARCHS4 Predicted Functions.

Functional Associations

NEDD4 has 10,128 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 130 datasets.

Click the + buttons to view associations for NEDD4 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Achilles Cell Line Gene Essentiality Profiles cell lines with fitness changed by NEDD4 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of NEDD4 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of NEDD4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of NEDD4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of NEDD4 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of NEDD4 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of NEDD4 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of NEDD4 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of NEDD4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of NEDD4 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CCLE Cell Line Proteomics Cell lines associated with NEDD4 protein from the CCLE Cell Line Proteomics dataset.
CellMarker Gene-Cell Type Associations cell types associated with NEDD4 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of NEDD4 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of NEDD4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of NEDD4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of NEDD4 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing NEDD4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing NEDD4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores cellular components containing NEDD4 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 cellular components containing NEDD4 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with NEDD4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with NEDD4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of NEDD4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with NEDD4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with NEDD4 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
CTD Gene-Disease Associations diseases associated with NEDD4 gene/protein from the curated CTD Gene-Disease Associations dataset.
dbGAP Gene-Trait Associations traits associated with NEDD4 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
DeepCoverMOA Drug Mechanisms of Action small molecule perturbations with high or low expression of NEDD4 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by NEDD4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores diseases associated with NEDD4 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 diseases associated with NEDD4 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with NEDD4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with NEDD4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with NEDD4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with NEDD4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at NEDD4 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of NEDD4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of NEDD4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing NEDD4 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GAD Gene-Disease Associations diseases associated with NEDD4 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GAD High Level Gene-Disease Associations diseases associated with NEDD4 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of NEDD4 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with NEDD4 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing NEDD4 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of NEDD4 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of NEDD4 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of NEDD4 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of NEDD4 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of NEDD4 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of NEDD4 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GO Biological Process Annotations 2015 biological processes involving NEDD4 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving NEDD4 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving NEDD4 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing NEDD4 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2023 cellular components containing NEDD4 protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing NEDD4 protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by NEDD4 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by NEDD4 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by NEDD4 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx eQTL 2025 SNPs regulating expression of NEDD4 gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of NEDD4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of NEDD4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of NEDD4 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GWAS Catalog SNP-Phenotype Associations phenotypes associated with NEDD4 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.
GWASdb SNP-Disease Associations diseases associated with NEDD4 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with NEDD4 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of NEDD4 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HMDB Metabolites of Enzymes interacting metabolites for NEDD4 protein from the curated HMDB Metabolites of Enzymes dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of NEDD4 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of NEDD4 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of NEDD4 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of NEDD4 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
HPM Cell Type and Tissue Protein Expression Profiles cell types and tissues with high or low expression of NEDD4 protein relative to other cell types and tissues from the HPM Cell Type and Tissue Protein Expression Profiles dataset.
Hub Proteins Protein-Protein Interactions interacting hub proteins for NEDD4 from the curated Hub Proteins Protein-Protein Interactions dataset.
HuBMAP ASCT+B Annotations cell types associated with NEDD4 gene from the HuBMAP ASCT+B dataset.
HuBMAP ASCT+B Augmented with RNA-seq Coexpression cell types associated with NEDD4 gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.
HuBMAP Azimuth Cell Type Annotations cell types associated with NEDD4 gene from the HuBMAP Azimuth Cell Type Annotations dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with NEDD4 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
IMPC Knockout Mouse Phenotypes phenotypes of mice caused by NEDD4 gene knockout from the IMPC Knockout Mouse Phenotypes dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for NEDD4 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of NEDD4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
KEA Substrates of Kinases kinases that phosphorylate NEDD4 protein from the curated KEA Substrates of Kinases dataset.
Kinase Library Serine Threonine Kinome Atlas kinases that phosphorylate NEDD4 protein from the Kinase Library Serine Threonine Atlas dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of NEDD4 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of NEDD4 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles cell lines with NEDD4 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of NEDD4 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of NEDD4 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures gene perturbations changing expression of NEDD4 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of NEDD4 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
LOCATE Curated Protein Localization Annotations cellular components containing NEDD4 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain NEDD4 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by NEDD4 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MiRTarBase microRNA Targets microRNAs targeting NEDD4 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of NEDD4 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of NEDD4 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by NEDD4 gene mutations from the MPO Gene-Phenotype Associations dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of NEDD4 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of NEDD4 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
NURSA Protein Complexes protein complexs containing NEDD4 protein recovered by IP-MS from the NURSA Protein Complexes dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for NEDD4 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of NEDD4 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of NEDD4 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving NEDD4 protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving NEDD4 protein from the Wikipathways PFOCR 2024 dataset.
Phosphosite Textmining Biological Term Annotations biological terms co-occuring with NEDD4 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.
PID Pathways pathways involving NEDD4 protein from the PID Pathways dataset.
Reactome Pathways 2014 pathways involving NEDD4 protein from the Reactome Pathways dataset.
Reactome Pathways 2024 pathways involving NEDD4 protein from the Reactome Pathways 2024 dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of NEDD4 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of NEDD4 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of NEDD4 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles cell types and tissues with high or low expression of NEDD4 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at NEDD4 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of NEDD4 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of NEDD4 gene from the RummaGEO Gene Perturbation Signatures dataset.
SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs drug perturbations changing phosphorylation of NEDD4 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs dataset.
SynGO Synaptic Gene Annotations synaptic terms associated with NEDD4 gene from the SynGO Synaptic Gene Annotations dataset.
Tabula Sapiens Gene-Cell Associations cell types with high or low expression of NEDD4 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of NEDD4 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of NEDD4 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of NEDD4 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of NEDD4 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of NEDD4 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of NEDD4 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of NEDD4 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with NEDD4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with NEDD4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
WikiPathways Pathways 2014 pathways involving NEDD4 protein from the Wikipathways Pathways 2014 dataset.
WikiPathways Pathways 2024 pathways involving NEDD4 protein from the WikiPathways Pathways 2024 dataset.