NEK9 Gene

Name	NIMA-related kinase 9
Description	This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNEK9 is a central NIMA‐related serine/threonine kinase that plays a critical role in cell cycle progression and mitotic regulation. Activated during early mitosis by upstream kinases such as CDK1 and Plk1, NEK9 phosphorylates and thereby activates its downstream effectors Nek6 and Nek7 to ensure proper spindle assembly, centrosome maturation, chromosome alignment, and timely cytokinesis. In this capacity, NEK9 also phosphorylates substrates like NEDD1 to coordinate the recruitment of γ‐tubulin to centrosomes, and its interaction with dimeric partners such as DYNLL/LC8 promotes multimerization and autoactivation of the kinase."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its canonical mitotic functions, NEK9 has emerged as an important player in cancer biology and cell motility. Elevated NEK9 expression is associated with tumor recurrence in glioblastoma and with intrinsic resistance to PI3K inhibition in triple‐negative breast cancer, while in gastric cancer NEK9‐dependent phosphorylation of ARHGEF2 modulates RhoA activation to promote cell motility. Moreover, oncogenic events such as EML4–ALK variant 3 fusions recruit NEK9 (alongside NEK7) to microtubules, leading to enhanced microtubule stabilization and increased migratory potential."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic and functional studies have broadened the significance of NEK9 beyond cell division. Loss‐of‐function mutations in NEK9 are causative for a lethal skeletal dysplasia characterized by impaired cell proliferation, cell cycle delay, and defective ciliary functions. In cancer cells, NEK9 depletion perturbs spindle dynamics and cytokinesis, triggering mitotic catastrophe, while in parallel studies NEK9 has been shown to phosphorylate LC3B—a key regulator of autophagy—and even to participate in transcriptional repression (e.g. of p53‐inducible genes during viral infection). Such findings point to a multifaceted role for NEK9 in maintaining normal cellular homeostasis and in influencing tumor cell survival, particularly in p53‐deficient settings."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent evidence also indicates that NEK9 contributes to the regulation of muscle contractility. In the heart, NEK9 phosphorylates the essential myosin light chain (ELC) in a calcium‐dependent manner, thereby adapting myocardial contractile function and inotropy to fluctuating hemodynamic demands. Disruption of NEK9 function via CRISPR/Cas9 techniques leads to cardiomyopathy in zebrafish models, underscoring its importance for normal cardiac performance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Christopher Belham, Joan Roig, Jennifer A Caldwell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M303663200"}], "href": "https://doi.org/10.1074/jbc.M303663200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12840024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12840024"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "M Teresa Bertran, Sara Sdelci, Laura Regué, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2011.179"}], "href": "https://doi.org/10.1038/emboj.2011.179"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21642957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21642957"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Joan Roig, Alexei Mikhailov, Christopher Belham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.972202"}], "href": "https://doi.org/10.1101/gad.972202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12101123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12101123"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mark W Richards, Laura O'Regan, Corine Mas-Droux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2009.09.038"}], "href": "https://doi.org/10.1016/j.molcel.2009.09.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19941817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19941817"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sara Sdelci, Martin Schütz, Roser Pinyol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2012.06.027"}], "href": "https://doi.org/10.1016/j.cub.2012.06.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22818914"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22818914"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Susana Eibes, Núria Gallisà-Suñé, Miquel Rosas-Salvans, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nek9 Phosphorylation Defines a New Role for TPX2 in Eg5-Dependent Centrosome Separation before Nuclear Envelope Breakdown."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2017.11.046"}], "href": "https://doi.org/10.1016/j.cub.2017.11.046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29276125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29276125"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tamanna Haq, Mark W Richards, Selena G Burgess, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms9771"}], "href": "https://doi.org/10.1038/ncomms9771"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26522158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26522158"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sierra N Cullati, Lilian Kabeche, Arminja N Kettenbach, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201512055"}], "href": "https://doi.org/10.1083/jcb.201512055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28630147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28630147"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Laura Regué, Sara Sdelci, M Teresa Bertran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.209080"}], "href": "https://doi.org/10.1074/jbc.M110.209080"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21454704"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21454704"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Robin T Varghese, Yanping Liang, Ting Guan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Survival kinase genes present prognostic significance in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7917"}], "href": "https://doi.org/10.18632/oncotarget.7917"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26956052"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26956052"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Filip Mundt, Sandeep Rajput, Shunqiang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mass Spectrometry-Based Proteomics Reveals Potential Roles of NEK9 and MAP2K4 in Resistance to PI3K Inhibition in Triple-Negative Breast Cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-17-1990"}], "href": "https://doi.org/10.1158/0008-5472.CAN-17-1990"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29472518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29472518"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Laura O'Regan, Giancarlo Barone, Rozita Adib, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.241505"}], "href": "https://doi.org/10.1242/jcs.241505"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32184261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32184261"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Guofang Lu, Siyuan Tian, Yi Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEK9, a novel effector of IL-6/STAT3, regulates metastasis of gastric cancer by targeting ARHGEF2 phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.53169"}], "href": "https://doi.org/10.7150/thno.53169"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33500736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33500736"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jillian P Casey, Kieran Brennan, Noemie Scheidel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recessive NEK9 mutation causes a lethal skeletal dysplasia with evidence of cell cycle and ciliary defects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddw054"}], "href": "https://doi.org/10.1093/hmg/ddw054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26908619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26908619"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yasuyuki Kaneta, Axel Ullrich "}, {"type": "b", "children": [{"type": "t", "text": "NEK9 depletion induces catastrophic mitosis by impairment of mitotic checkpoint control and spindle dynamics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.04.105"}], "href": "https://doi.org/10.1016/j.bbrc.2013.04.105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23665325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23665325"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Birendra Kumar Shrestha, Mads Skytte Rasmussen, Yakubu Princely Abudu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NIMA-related kinase 9-mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA119.010068"}], "href": "https://doi.org/10.1074/jbc.RA119.010068"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31857374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31857374"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Richard Jung, Sandi Radko, Peter Pelka "}, {"type": "b", "children": [{"type": "t", "text": "The Dual Nature of Nek9 in Adenovirus Replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02392-15"}], "href": "https://doi.org/10.1128/JVI.02392-15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26676776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26676776"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Daisuke Kurioka, Fumitaka Takeshita, Koji Tsuta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEK9-dependent proliferation of cancer cells lacking functional p53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep06111"}], "href": "https://doi.org/10.1038/srep06111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25131192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25131192"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Ziru Xu, Wenping Shen, Aifeng Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased Nek9 expression correlates with aggressive behaviour and predicts unfavourable prognosis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathology (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pathol.2019.11.008"}], "href": "https://doi.org/10.1016/j.pathol.2019.11.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32098687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32098687"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Marion Müller, Rose Eghbalian, Jes-Niels Boeckel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-022-33658-2"}], "href": "https://doi.org/10.1038/s41467-022-33658-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36266340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36266340"}]}]}]}
Synonyms	NERCC, LCCS10, NERCC1, APUG
Proteins	NEK9_HUMAN
NCBI Gene ID	91754
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NEK9 has 8,241 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 130 datasets.

Click the + buttons to view associations for NEK9 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NEK9 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NEK9 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NEK9 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NEK9 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NEK9 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NEK9 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NEK9 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NEK9 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NEK9 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NEK9 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of NEK9 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NEK9 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NEK9 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with NEK9 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with NEK9 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with NEK9 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NEK9 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NEK9 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NEK9 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with NEK9 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NEK9 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NEK9 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing NEK9 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing NEK9 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NEK9 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NEK9 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing NEK9 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NEK9 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NEK9 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NEK9 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NEK9 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by NEK9 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with NEK9 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NEK9 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NEK9 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NEK9 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NEK9 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NEK9 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NEK9 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NEK9 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing NEK9 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.