HGNC Family | Fibronectin type III domain containing, Immunoglobulin superfamily domain containing |
Name | neogenin 1 |
Description | This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNeogenin (NEO1) has emerged as an important co‐receptor in the regulation of bone morphogenetic protein (BMP) signaling and systemic iron homeostasis. In hepatocytes, NEO1 interacts with hemojuvelin (HJV) and related repulsive guidance molecules (RGMs) to modulate the transcription of hepcidin, a key iron regulatory hormone. Structural studies have delineated how NEO1 binds BMP2 in complex with RGMs, and in vitro studies established that while HJV–BMP signaling occurs via a defined subset of BMP ligands and receptors, the participation of NEO1 in such complexes can vary, thereby influencing HJV processing and cleavage by proteases such as matriptase‐2. Collectively, these studies indicate that NEO1 participates in—and in certain contexts modulates—the capacity of BMP signaling to affect iron metabolism."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in modulating extracellular BMP signals, NEO1 functions as a multifunctional dependence receptor that undergoes regulated proteolytic cleavage. Gamma‐secretase–mediated release of its intracellular domain (NeICD) enables NEO1 to translocate to the nucleus and influence gene transcription. In addition, through interactions with intracellular effectors such as the death‐associated protein kinase (DAPK), NEO1 can trigger pro‐apoptotic cascades in the absence of ligand engagement. Its expression in neural progenitors and mammary cap cells—as well as its regulation by morphogens like Sonic Hedgehog—support a role for NEO1 in guiding neuronal migration and cell fate decisions, with emerging links to neurodevelopmental disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn diverse cancer types, the role of NEO1 appears context dependent. In some studies, decreased NEO1 levels (for example, as mediated by microRNAs in glioblastoma or loss in glioma) correlate with enhanced tumor cell proliferation, migration, and invasion—consistent with a tumor‐suppressive function. Conversely, other investigations in gastric, ovarian, breast, hepatocellular, and melanoma models indicate that NEO1 expression can promote cell motility and survival via activation of oncogenic signaling cascades (e.g. ERK1/2, PI3K/Akt) or through modulation of epithelial–mesenchymal transition. Additionally, in neuroblastoma cells NEO1 engagement by netrin family ligands appears essential for maintaining both pro‐migratory and survival signals. These seemingly contradictory roles underscore a complex, tissue‐ and context‐specific regulation of tumorigenesis by NEO1."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNEO1 also contributes to a variety of additional biological processes that underpin tissue integrity and homeostasis. It plays a key role in maintaining epithelial adherens junction stability through the recruitment of actin regulatory complexes, thereby influencing cell–cell adhesion and cadherin recycling. In the context of pluripotent stem cells, netrin‐1 signaling via NEO1 has been shown to regulate self‐renewal and differentiation by simultaneously modulating Wnt and MAPK pathways. Furthermore, through actions in astrocytes and placental trophoblasts, NEO1 participates in the regulation of inflammatory resolution, synaptic transmission, and cell invasion during placental development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "30", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yin Xia, Jodie L Babitt, Yisrael Sidis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-09-111567"}], "href": "https://doi.org/10.1182/blood-2007-09-111567"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18326817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18326817"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Eleanor G Healey, Benjamin Bishop, Jonathan Elegheert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.3016"}], "href": "https://doi.org/10.1038/nsmb.3016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25938661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25938661"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Meiko Hagihara, Mitsuharu Endo, Katsuhiko Hata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neogenin, a receptor for bone morphogenetic proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.180919"}], "href": "https://doi.org/10.1074/jbc.M110.180919"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21149453"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21149453"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "An-Sheng Zhang, Fan Yang, Jiaohong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.027318"}], "href": "https://doi.org/10.1074/jbc.M109.027318"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19564337"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19564337"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Caroline A Enns, Riffat Ahmed, An-Sheng Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.363937"}], "href": "https://doi.org/10.1074/jbc.M112.363937"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22893705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22893705"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Robin Kuns-Hashimoto, David Kuninger, Mahta Nili, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00563.2007"}], "href": "https://doi.org/10.1152/ajpcell.00563.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18287331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18287331"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "An-Sheng Zhang, Fan Yang, Kathrin Meyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M710527200"}], "href": "https://doi.org/10.1074/jbc.M710527200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18445598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18445598"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Takahide Itokazu, Yuki Fujita, Ryosuke Takahashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the neogenin-binding site on the repulsive guidance molecule A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0032791"}], "href": "https://doi.org/10.1371/journal.pone.0032791"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22396795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22396795"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Fan Yang, Anthony P West, Pamela J Bjorkman "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of a hemojuvelin-binding fragment of neogenin at 1.8Å."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Struct Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jsb.2010.10.005"}], "href": "https://doi.org/10.1016/j.jsb.2010.10.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20971194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20971194"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "David Goldschneider, Nicolas Rama, Catherine Guix, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The neogenin intracellular domain regulates gene transcription via nuclear translocation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.02114-07"}], "href": "https://doi.org/10.1128/MCB.02114-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18391016"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18391016"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Y Fujita, J Taniguchi, M Uchikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neogenin regulates neuronal survival through DAP kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2008.92"}], "href": "https://doi.org/10.1038/cdd.2008.92"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18583991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18583991"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jeong Eon Lee, Hee Joung Kim, Ji Yeon Bae, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neogenin expression may be inversely correlated to the tumorigenicity of human breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-5-154"}], "href": "https://doi.org/10.1186/1471-2407-5-154"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16324219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16324219"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Luis A Milla, Andrea Arros, Natalie Espinoza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.28330"}], "href": "https://doi.org/10.1002/ijc.28330"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23775842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23775842"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "D Bradford, R L M Faull, M A Curtis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the netrin/RGMa receptor neogenin in neurogenic regions of the mouse and human adult forebrain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Comp Neurol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cne.22397"}], "href": "https://doi.org/10.1002/cne.22397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20575069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20575069"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Wai-Kwan Siu, Ching-Wan Lam, Wei-Wei Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unmasking a novel disease gene NEO1 associated with autism spectrum disorders by a hemizygous deletion on chromosome 15 and a functional polymorphism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Behav Brain Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbr.2015.10.041"}], "href": "https://doi.org/10.1016/j.bbr.2015.10.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26518331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26518331"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yichen Song, Ping Wang, Wei Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-18a regulates the proliferation, migration and invasion of human glioblastoma cell by targeting neogenin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2014.03.009"}], "href": "https://doi.org/10.1016/j.yexcr.2014.03.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24657544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24657544"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Seok-Jun Kim, Yuan-Guo Wang, Hyun-Woo Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of neogenin-1 increases cell proliferation and motility in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.1960"}], "href": "https://doi.org/10.18632/oncotarget.1960"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24930499"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24930499"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Bin Lv, Chunhua Song, Lijun Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-4 as a biomarker promotes cell proliferation and invasion in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3400"}], "href": "https://doi.org/10.18632/oncotarget.3400"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25909166"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25909166"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Shuk-Mei Ho, Kin-Mang Lau, Samuel Chi-Ho Mok, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1206437"}], "href": "https://doi.org/10.1038/sj.onc.1206437"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12833147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12833147"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Kei Kaneko, Yuki Ohkawa, Noboru Hashimoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neogenin, Defined as a GD3-associated Molecule by Enzyme-mediated Activation of Radical Sources, Confers Malignant Properties via Intracytoplasmic Domain in Melanoma Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.708834"}], "href": "https://doi.org/10.1074/jbc.M115.708834"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27288875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27288875"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Hengyi Qu, Huabo Sun, Xueping Wang "}, {"type": "b", "children": [{"type": "t", "text": "Neogenin-1 Promotes Cell Proliferation, Motility, and Adhesion by Up-Regulation of Zinc Finger E-Box Binding Homeobox 1 Via Activating the Rac1/PI3K/AKT Pathway in Gastric Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000492255"}], "href": "https://doi.org/10.1159/000492255"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30064133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30064133"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Xinmin Wu, Yunqian Li, Xilin Wan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of neogenin accelerated glioma progression through promoter Methylation and its overexpression in SHG-44 Induced Apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0038074"}], "href": "https://doi.org/10.1371/journal.pone.0038074"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22666451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22666451"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Andrea A Villanueva, Paulina Falcón, Natalie Espinoza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Netrin-4/ Neogenin-1 axis promotes neuroblastoma cell survival and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.14213"}], "href": "https://doi.org/10.18632/oncotarget.14213"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28038459"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28038459"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Caroline M Forrest, Kara McNair, Maria C J Vincenten, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective depletion of tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin by environmental and endogenous serine proteases: linking diet and cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-016-2795-y"}], "href": "https://doi.org/10.1186/s12885-016-2795-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27716118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27716118"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Qingsong Zhang, Fang Liang, Yang Ke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of neogenin inhibits cell proliferation and induces apoptosis in human MDA-MB-231 breast carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.4004"}], "href": "https://doi.org/10.3892/or.2015.4004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25998984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25998984"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Vishal Chaturvedi, Alexandre Fournier-Level, Helen M Cooper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of Neogenin1 in human colorectal carcinoma cells causes a partial EMT and wound-healing response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-40886-y"}], "href": "https://doi.org/10.1038/s41598-019-40886-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30858446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30858446"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Gustavo Untiveros, Aleksandr Raskind, Laura Linares, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1 Stimulates Migration of Neogenin Expressing Aggressive Melanoma Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms232112751"}], "href": "https://doi.org/10.3390/ijms232112751"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36361539"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36361539"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Jyothi Vennela, Biju Pottakkat, Bala Subramaniyan Vairappan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatic Expression of NTN4 and Its Receptors in Patients with Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.31557/APJCP.2023.24.12.4285"}], "href": "https://doi.org/10.31557/APJCP.2023.24.12.4285"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38156865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38156865"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Yun Yang, Yong Wang, Yan DU, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Correlation of netrin-1 expression with invasion of extra villous trophoblasts]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Fu Chan Ke Za Zhi (2009)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19570425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19570425"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Natalie K Lee, Ka Wai Fok, Amanda White, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms11082"}], "href": "https://doi.org/10.1038/ncomms11082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27029596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27029596"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Martin Schlegel, Andreas Körner, Torsten Kaussen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of neogenin fosters resolution of inflammation and tissue regeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI96259"}], "href": "https://doi.org/10.1172/JCI96259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30222138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30222138"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Aurélia Huyghe, Giacomo Furlan, Duygu Ozmadenci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41556-020-0483-2"}], "href": "https://doi.org/10.1038/s41556-020-0483-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32231305"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32231305"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Dong Sun, Zhi-Bing Tan, Xiang-Dong Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hippocampal astrocytic neogenin regulating glutamate uptake, a critical pathway for preventing epileptic response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2022921118"}], "href": "https://doi.org/10.1073/pnas.2022921118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33850017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33850017"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Wanying Xing, Qiang Li, Rangjuan Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neogenin expression is inversely associated with breast cancer grade in ex vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Surg Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1477-7819-12-352"}], "href": "https://doi.org/10.1186/1477-7819-12-352"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25416629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25416629"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "M Dakouane-Giudicelli, C Duboucher, J Fortemps, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and localization of netrin-4 and neogenin in human first trimester and term placenta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Placenta (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.placenta.2012.05.011"}], "href": "https://doi.org/10.1016/j.placenta.2012.05.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22705235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22705235"}]}]}]}
|
Synonyms | NTN1R2, IGDCC2, NGN |
Proteins | NEO1_HUMAN |
NCBI Gene ID | 4756 |
API | |
Download Associations | |
Predicted Functions |
![]() |
Co-expressed Genes |
![]() |
Expression in Tissues and Cell Lines |
![]() |
NEO1 has 6,681 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 117 datasets.
Click the + buttons to view associations for NEO1 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of NEO1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of NEO1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of NEO1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of NEO1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of NEO1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of NEO1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of NEO1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of NEO1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of NEO1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of NEO1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CCLE Cell Line Proteomics | Cell lines associated with NEO1 protein from the CCLE Cell Line Proteomics dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with NEO1 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of NEO1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of NEO1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of NEO1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of NEO1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing NEO1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing NEO1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing NEO1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing NEO1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with NEO1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with NEO1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of NEO1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with NEO1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with NEO1 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with NEO1 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
dbGAP Gene-Trait Associations | traits associated with NEO1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of NEO1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by NEO1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with NEO1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with NEO1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with NEO1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with NEO1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with NEO1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at NEO1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of NEO1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of NEO1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing NEO1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with NEO1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with NEO1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of NEO1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with NEO1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing NEO1 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of NEO1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of NEO1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of NEO1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of NEO1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of NEO1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of NEO1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GlyGen Glycosylated Proteins | ligands (chemical) binding NEO1 protein from the GlyGen Glycosylated Proteins dataset. | |
GO Biological Process Annotations 2015 | biological processes involving NEO1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving NEO1 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving NEO1 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing NEO1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing NEO1 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by NEO1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GTEx eQTL 2025 | SNPs regulating expression of NEO1 gene from the GTEx eQTL 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of NEO1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of NEO1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of NEO1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of NEO1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
GWASdb SNP-Disease Associations | diseases associated with NEO1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with NEO1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of NEO1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of NEO1 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of NEO1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of NEO1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of NEO1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for NEO1 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with NEO1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for NEO1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of NEO1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEGG Pathways | pathways involving NEO1 protein from the KEGG Pathways dataset. | |
Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate NEO1 protein from the Kinase Library Serine Threonine Atlas dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of NEO1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of NEO1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with NEO1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of NEO1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of NEO1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of NEO1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of NEO1 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing NEO1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain NEO1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by NEO1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting NEO1 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of NEO1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by NEO1 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of NEO1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of NEO1 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
NURSA Protein Complexes | protein complexs containing NEO1 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for NEO1 from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of NEO1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of NEO1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving NEO1 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving NEO1 protein from the Wikipathways PFOCR 2024 dataset. | |
Reactome Pathways 2014 | pathways involving NEO1 protein from the Reactome Pathways dataset. | |
Reactome Pathways 2024 | pathways involving NEO1 protein from the Reactome Pathways 2024 dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of NEO1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of NEO1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at NEO1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of NEO1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of NEO1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with NEO1 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs | drug perturbations changing phosphorylation of NEO1 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs dataset. | |
SynGO Synaptic Gene Annotations | synaptic terms associated with NEO1 gene from the SynGO Synaptic Gene Annotations dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of NEO1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of NEO1 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of NEO1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of NEO1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of NEO1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of NEO1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of NEO1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of NEO1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with NEO1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with NEO1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
WikiPathways Pathways 2014 | pathways involving NEO1 protein from the Wikipathways Pathways 2014 dataset. | |
WikiPathways Pathways 2024 | pathways involving NEO1 protein from the WikiPathways Pathways 2024 dataset. | |