{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNestin is a class VI intermediate filament protein originally identified in neuroepithelial stem cells and now recognized as a hallmark of various progenitor populations. Its expression marks migrating and proliferating progenitors during embryogenesis as well as adult stem and progenitor cells in tissues such as the nervous system, bone marrow, and even pancreatic islets. These studies establish nestin as a characteristic indicator of multipotentiality and regenerative capacity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": " In contrast, certain mesenchymal populations, such as a subset of dermal fibroblasts, lack nestin expression, underscoring the contextual specificity of this marker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in development and tissue regeneration, nestin marks dynamic remodeling during angiogenesis. It is expressed by immature endothelial cells during neovascularization in embryonic tissues as well as in the angiogenic vasculature of tumors, making it a reliable marker of newly formed vessels in various cancers. In colorectal cancer and other solid tumors, nestin-positive microvessels exhibit high proliferative activity, supporting its utility as an angiogenic indicator."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cancer the function of nestin extends well beyond cell identification. Numerous studies across cancer types—including gliomas, neuroblastomas, pancreatic, prostate, lung, melanoma, ovarian, and nerve sheath tumors—demonstrate that nestin is integrally involved in regulating cancer stem cell properties, cell proliferation, migration, invasion, and chemoresistance. For instance, nestin expression is associated with enhanced tumor aggressiveness and poorer patient outcomes, and its regulation by factors such as p53, N-myc, SOX9/SOX10, and c-Myc underscores its central role in modulating stemness and tumor cell plasticity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "36"}]}, {"type": "t", "text": " In several contexts, nestin not only serves as a cell fate marker but also actively modulates cytoskeletal organization and signaling pathways (for example, by acting as a scaffold for Cdk5, FAK, and integrins, or through its nuclear interactions with lamin A/C) that promote cell survival, motility, and resistance to stress‐induced senescence.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "C Wiese, A Rolletschek, G Kania, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nestin expression--a property of multi-lineage progenitor cells?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-004-4144-6"}], "href": "https://doi.org/10.1007/s00018-004-4144-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15526158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15526158"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sandra Pinho, Julie Lacombe, Maher Hanoun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDGFRα and CD51 mark human nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20122252"}], "href": "https://doi.org/10.1084/jem.20122252"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23776077"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23776077"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Aurora Bernal, Lorena Arranz "}, {"type": "b", "children": [{"type": "t", "text": "Nestin-expressing progenitor cells: function, identity and therapeutic implications."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-018-2794-z"}], "href": "https://doi.org/10.1007/s00018-018-2794-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29541793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29541793"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "James C Walcott, Jan M Provis "}, {"type": "b", "children": [{"type": "t", "text": "Müller cells express the neuronal progenitor cell marker nestin in both differentiated and undifferentiated human foetal retina."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Ophthalmol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1046/j.1442-9071.2003.00638.x"}], "href": "https://doi.org/10.1046/j.1442-9071.2003.00638.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12786777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12786777"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Michael Eberhardt, Patrick Salmon, Marc-Alexander von Mach, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multipotential nestin and Isl-1 positive mesenchymal stem cells isolated from human pancreatic islets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2006.05.016"}], "href": "https://doi.org/10.1016/j.bbrc.2006.05.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16713999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16713999"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Michael L Hendrickson, Abigail J Rao, Omar N A Demerdash, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of nestin by neural cells in the adult rat and human brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0018535"}], "href": "https://doi.org/10.1371/journal.pone.0018535"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21490921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21490921"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Fu Guo Chen, Wen Jie Zhang, Dan Bi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clonal analysis of nestin(-) vimentin(+) multipotent fibroblasts isolated from human dermis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.03478"}], "href": "https://doi.org/10.1242/jcs.03478"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17652163"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17652163"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "J Mokrý, D Cízková, S Filip, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nestin expression by newly formed human blood vessels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells Dev (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/scd.2004.13.658"}], "href": "https://doi.org/10.1089/scd.2004.13.658"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15684833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15684833"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Nobuhisa Teranishi, Zenya Naito, Toshiyuki Ishiwata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of neovasculature using nestin in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17273760"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17273760"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kosuke Narita, Yoko Matsuda, Masahiro Seike, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nestin regulates proliferation, migration, invasion and stemness of lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2014.2278"}], "href": "https://doi.org/10.3892/ijo.2014.2278"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24481417"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24481417"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Masanori Aihara, Ken-ichi Sugawara, Seiji Torii, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Angiogenic endothelium-specific nestin expression is enhanced by the first intron of the nestin gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Invest (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/labinvest.3700186"}], "href": "https://doi.org/10.1038/labinvest.3700186"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15502861"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15502861"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Rikke H Dahlrot, Steinbjørn Hansen, Stine S Jensen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical value of CD133 and nestin in patients with glioma: a population-based study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2014)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25120750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25120750"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jakub Neradil, Renata Veselska "}, {"type": "b", "children": [{"type": "t", "text": "Nestin as a marker of cancer stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.12691"}], "href": "https://doi.org/10.1111/cas.12691"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25940879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25940879"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Darjus F Tschaharganeh, Wen Xue, Diego F Calvisi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2014.05.051"}], "href": "https://doi.org/10.1016/j.cell.2014.05.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25083869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25083869"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Wolfram Kleeberger, G Steven Bova, Matthew E Nielsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Roles for the stem cell associated intermediate filament Nestin in prostate cancer migration and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-0806"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-0806"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17909025"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17909025"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Cecilia M Sahlgren, Hanna-Mari Pallari, Tao He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7601366"}], "href": "https://doi.org/10.1038/sj.emboj.7601366"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17036052"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17036052"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Zuowei Zhao, Ping Lu, Hao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nestin positively regulates the Wnt/β-catenin pathway and the proliferation, survival and invasiveness of breast cancer stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13058-014-0408-8"}], "href": "https://doi.org/10.1186/s13058-014-0408-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25056574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25056574"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Sharon K Thomas, Conrad A Messam, Barbara A Spengler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nestin is a potential mediator of malignancy in human neuroblastoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M312663200"}], "href": "https://doi.org/10.1074/jbc.M312663200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15117961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15117961"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Bin Wu, Caixing Sun, Fang Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Do relevant markers of cancer stem cells CD133 and Nestin indicate a poor prognosis in glioma patients? A systematic review and meta-analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-015-0163-4"}], "href": "https://doi.org/10.1186/s13046-015-0163-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25967234"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25967234"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Huei-Ting Su, Ching-Chieh Weng, Pi-Jung Hsiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stem cell marker nestin is critical for TGF-β1-mediated tumor progression in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-12-0511"}], "href": "https://doi.org/10.1158/1541-7786.MCR-12-0511"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23552743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23552743"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Alexander Birbrair, Tan Zhang, Zhong-Min Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Skeletal muscle neural progenitor cells exhibit properties of NG2-glia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2012.09.008"}], "href": "https://doi.org/10.1016/j.yexcr.2012.09.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22999866"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22999866"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Franca Piras, Maria Teresa Perra, Daniela Murtas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The stem cell marker nestin predicts poor prognosis in human melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2010)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19956860"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19956860"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Masao Kawamoto, Toshiyuki Ishiwata, Kazumitsu Cho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nestin expression correlates with nerve and retroperitoneal tissue invasion in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Pathol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humpath.2008.02.022"}], "href": "https://doi.org/10.1016/j.humpath.2008.02.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18799194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18799194"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "J R Parfitt, C A McLean, M G Joseph, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Granular cell tumours of the gastrointestinal tract: expression of nestin and clinicopathological evaluation of 11 patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histopathology (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2559.2006.02352.x"}], "href": "https://doi.org/10.1111/j.1365-2559.2006.02352.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16487364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16487364"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Yoko Matsuda, Toshiyuki Ishiwata, Hisashi Yoshimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of nestin suppresses stem cell phenotype of glioblastomas through the alteration of post-translational modification of heat shock protein HSPA8/HSC71."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2014.12.030"}], "href": "https://doi.org/10.1016/j.canlet.2014.12.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25527454"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25527454"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Yoko Matsuda, Shoko Kure, Toshiyuki Ishiwata "}, {"type": "b", "children": [{"type": "t", "text": "Nestin and other putative cancer stem cell markers in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Mol Morphol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00795-012-0571-x"}], "href": "https://doi.org/10.1007/s00795-012-0571-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22718289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22718289"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Sergiu Scobioala, Rainer Klocke, Michael Kuhlmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of nestin in the infarcted myocardium potentially indicates differentiation of resident cardiac stem cells into various lineages including cardiomyocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.07-8252com"}], "href": "https://doi.org/10.1096/fj.07-8252com"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17984177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17984177"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Thomas Cawsey, Johan Duflou, Cynthia Shannon Weickert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nestin-Positive Ependymal Cells Are Increased in the Human Spinal Cord after Traumatic Central Nervous System Injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurotrauma (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/neu.2014.3575"}], "href": "https://doi.org/10.1089/neu.2014.3575"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25599268"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25599268"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Hyemin Lee, Hyo-Jung Lee, Ji Hoon Jung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Melatonin disturbs SUMOylation-mediated crosstalk between c-Myc and nestin via MT1 activation and promotes the sensitivity of paclitaxel in brain cancer stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pineal Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jpi.12496"}], "href": "https://doi.org/10.1111/jpi.12496"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29654697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29654697"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Yan Zhang, Shan Zeng, Junli Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nestin overexpression in hepatocellular carcinoma associates with epithelial-mesenchymal transition and chemoresistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-016-0387-y"}], "href": "https://doi.org/10.1186/s13046-016-0387-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27412382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27412382"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Satoko Shimada, Toyonori Tsuzuki, Makoto Kuroda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nestin expression as a new marker in malignant peripheral nerve sheath tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Int (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1440-1827.2006.02059.x"}], "href": "https://doi.org/10.1111/j.1440-1827.2006.02059.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17300669"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17300669"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Anna Flammiger, Robert Besch, Anthony L Cook, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOX9 and SOX10 but not BRN2 are required for nestin expression in human melanoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2008.316"}], "href": "https://doi.org/10.1038/jid.2008.316"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18923447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18923447"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Feng Wan, Christel Herold-Mende, Benito Campos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of stem cell-related markers and survival in astrocytic gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomarkers (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/1354750X.2010.536256"}], "href": "https://doi.org/10.3109/1354750X.2010.536256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21323603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21323603"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Q Qin, Y Sun, M Fei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of putative stem marker nestin and CD133 in advanced serous ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2012_040"}], "href": "https://doi.org/10.4149/neo_2012_040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22296500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22296500"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Claire L Hyder, Glorianne Lazaro, Joanna W Pylvänäinen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nestin regulates prostate cancer cell invasion by influencing the localisation and functions of FAK and integrins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.125062"}], "href": "https://doi.org/10.1242/jcs.125062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24610946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24610946"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Yanan Zhang, Jiancheng Wang, Weijun Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-05808-y"}], "href": "https://doi.org/10.1038/s41467-018-05808-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30190500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30190500"}]}]}]}