{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA review of the provided abstracts reveals an extensive investigation into bone morphogenetic protein (BMP)–mediated signaling pathways that regulate osteoblast differentiation, chondrogenesis, and tissue regeneration. These studies detail key molecular events—such as BMP2‐driven activation of Smad proteins, cross talk with Wnt/β–catenin cascades, and transcriptional regulation by factors including Runx2, Dlx5, Msx, and others—that together orchestrate the formation and repair of bone."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional abstracts expand on these themes by elucidating downstream transcriptional networks (involving ATF4, Osterix, and Hey1), the interplay between BMP and other signals (such as transforming growth factor–β and Notch), and the significance of these pathways in pathological contexts ranging from fracture repair to vascular calcification."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther reports examine aspects of extracellular matrix formation, the role of heparin and the regulation of transcription by homeodomain proteins during osteogenesis, as well as the integration of additional signals (including those from IGF-I and reactive oxygen species) into BMP2-driven bone formation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "25", "end_ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, several studies focus on the modulation of BMP signaling by factors related to subcellular trafficking, phosphatidylinositol 3-kinase/Akt signaling, and the contributions of angiocrine cues to systemic processes such as iron homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "33", "end_ref": "36"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, despite the breadth and depth of these investigations into BMP‐related pathways and osteogenic regulation, none of the abstracts address the function or mechanistic role of NEURL1‑AS1. Although NEURL1‑AS1—a long noncoding RNA that in other contexts has been implicated in the regulation of cell signaling—is of emerging interest in biomedical research, its specific involvement in BMP‐driven processes such as osteoblast differentiation, chondrogenesis, or tissue regeneration is not discussed in any of the above studies. Therefore, while these articles provide a detailed framework of the molecular circuitry governing bone formation and repair, they do not offer insights into whether or how NEURL1‑AS1 might interact with or modulate these pathways. This gap in the literature identifies an important avenue for future research to determine if NEURL1‑AS1 plays a regulatory role in BMP‐mediated osteogenic signaling.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Georges Rawadi, Béatrice Vayssière, Fred Dunn, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.0020216"}], "href": "https://doi.org/10.1371/journal.pgen.0020216"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17194222"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17194222"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhaoyong Li, Mohammad Q Hassan, Stefano Volinia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A microRNA signature for a BMP2-induced osteoblast lineage commitment program."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0804438105"}], "href": "https://doi.org/10.1073/pnas.0804438105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18784367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18784367"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lijiang Ma, Mei-Fang Lu, Robert J Schwartz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.02156"}], "href": "https://doi.org/10.1242/dev.02156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16314491"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16314491"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mi-Hye Lee, Youn-Jeong Kim, Hyun-Jung Kim, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M801774200"}], "href": "https://doi.org/10.1074/jbc.M801774200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18703512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18703512"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "C M Champagne, J Takebe, S Offenbacher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Macrophage cell lines produce osteoinductive signals that include bone morphogenetic protein-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bone (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s8756-3282(01)00638-x"}], "href": "https://doi.org/10.1016/s8756-3282(01"}, {"type": "t", "text": "00638-x) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11792561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11792561"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Nandini Ghosh-Choudhury, Sherry L Abboud, Riko Nishimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M205053200"}], "href": "https://doi.org/10.1074/jbc.M205053200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12084724"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12084724"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Baohong Zhao, Takenobu Katagiri, Hiromitsu Toyoda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M511039200"}], "href": "https://doi.org/10.1074/jbc.M511039200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16754660"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16754660"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Rongrong Zhang, Babatunde O Oyajobi, Stephen E Harris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bone (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bone.2012.09.029"}], "href": "https://doi.org/10.1016/j.bone.2012.09.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23032104"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23032104"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "James C H Hardwick, Gijs R Van Den Brink, Sylvia A Bleuming, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2003.10.067"}], "href": "https://doi.org/10.1053/j.gastro.2003.10.067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14699493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14699493"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Atsushi Saito, Kimiko Ochiai, Shinichi Kondo, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M807709200"}], "href": "https://doi.org/10.1074/jbc.M807709200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19251704"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19251704"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Quanxi Li, Athilakshmi Kannan, Wei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bone morphogenetic protein 2 functions via a conserved signaling pathway involving Wnt4 to regulate uterine decidualization in the mouse and the human."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M704723200"}], "href": "https://doi.org/10.1074/jbc.M704723200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17711857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17711857"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Arnau Ulsamer, María José Ortuño, Silvia Ruiz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M704724200"}], "href": "https://doi.org/10.1074/jbc.M704724200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18056716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18056716"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Bing Shu, Ming Zhang, Rong Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.083659"}], "href": "https://doi.org/10.1242/jcs.083659"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21984813"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21984813"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Danièle Noël, Dan Gazit, Celine Bouquet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Short-term BMP-2 expression is sufficient for in vivo osteochondral differentiation of mesenchymal stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1634/stemcells.22-1-74"}], "href": "https://doi.org/10.1634/stemcells.22-1-74"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14688393"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14688393"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Luis Luna-Zurita, Belén Prados, Joaquim Grego-Bessa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI42666"}], "href": "https://doi.org/10.1172/JCI42666"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20890042"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20890042"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Andrew P Sage, Jinxiu Lu, Yin Tintut, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kidney Int (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ki.2010.390"}], "href": "https://doi.org/10.1038/ki.2010.390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20944546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20944546"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Shuying Yang, Daoyan Wei, Dian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In vitro and in vivo synergistic interactions between the Runx2/Cbfa1 transcription factor and bone morphogenetic protein-2 in stimulating osteoblast differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1359/jbmr.2003.18.4.705"}], "href": "https://doi.org/10.1359/jbmr.2003.18.4.705"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12674331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12674331"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Mohammad Q Hassan, Rahul S Tare, Suk Hee Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M604508200"}], "href": "https://doi.org/10.1074/jbc.M604508200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17060321"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17060321"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Aditi Mukherjee, Peter Rotwein "}, {"type": "b", "children": [{"type": "t", "text": "Akt promotes BMP2-mediated osteoblast differentiation and bone development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.042770"}], "href": "https://doi.org/10.1242/jcs.042770"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19208758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19208758"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Youn-Jeong Kim, Mi-Hye Lee, John M Wozney, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bone morphogenetic protein-2-induced alkaline phosphatase expression is stimulated by Dlx5 and repressed by Msx2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M404145200"}], "href": "https://doi.org/10.1074/jbc.M404145200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15383550"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15383550"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Kenji Hata, Riko Nishimura, Fumiyo Ikeda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor gamma during bone morphogenetic protein 2-induced adipogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e02-06-0356"}], "href": "https://doi.org/10.1091/mbc.e02-06-0356"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12589053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12589053"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Yan Chen, Heather C Whetstone, Andrew Youn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Beta-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M602700200"}], "href": "https://doi.org/10.1074/jbc.M602700200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17085452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17085452"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Satoru Yamada, Miki Tomoeda, Yasuhiro Ozawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PLAP-1/asporin, a novel negative regulator of periodontal ligament mineralization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M611181200"}], "href": "https://doi.org/10.1074/jbc.M611181200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17522060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17522060"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Ken-ichi Fujita, Siegfried Janz "}, {"type": "b", "children": [{"type": "t", "text": "Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-6-71"}], "href": "https://doi.org/10.1186/1476-4598-6-71"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17971207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17971207"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Ming Zhao, Guozhi Xiao, Janice E Berry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bone morphogenetic protein 2 induces dental follicle cells to differentiate toward a cementoblast/osteoblast phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1359/jbmr.2002.17.8.1441"}], "href": "https://doi.org/10.1359/jbmr.2002.17.8.1441"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12162498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12162498"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Won-Gu Jang, Eun-Jung Kim, Don-Kyu Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BMP2 protein regulates osteocalcin expression via Runx2-mediated Atf6 gene transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.253187"}], "href": "https://doi.org/10.1074/jbc.M111.253187"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22102412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22102412"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Eva Balint, David Lapointe, Hicham Drissi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phenotype discovery by gene expression profiling: mapping of biological processes linked to BMP-2-mediated osteoblast differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.10515"}], "href": "https://doi.org/10.1002/jcb.10515"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12704803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12704803"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Xiangyang Jiao, Paul C Billings, Michael P O'Connell, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.20258"}], "href": "https://doi.org/10.1002/jcp.20258"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15573378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15573378"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Philipp-Sebastian Koch, Victor Olsavszky, Friederike Ulbrich, et al. 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