NFASC Gene

HGNC Family	Immunoglobulin superfamily domain containing, Fibronectin type III domain containing
Name	neurofascin
Description	This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNeurofascin (NFASC) is a critical cell adhesion molecule that underpins the assembly and maintenance of specialized axonal domains, particularly the nodes of Ranvier and paranodal junctions. The two main isoforms—neuronal NF186 and glial NF155—mediate distinct yet complementary functions: NF186 coordinates the clustering of voltage‐gated sodium channels at nodes to ensure rapid conduction, whereas NF155 facilitates the formation and stabilization of paranodal axo‐glial junctions. Disruption of extracellular immunoglobulin domains in NF155, for example, leads to compromised paranodal architecture and impaired ion channel segregation, underscoring NFASC’s indispensable role in maintaining neural circuit integrity through its adhesive interactions and structural organization."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAutoantibodies against NFASC isoforms have emerged as pivotal mediators in several immune‐driven neuropathies. In conditions such as multiple sclerosis, Guillain–Barré syndrome, chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and combined central and peripheral demyelination (CCPD), pathogenic autoantibodies target NFASC at nodal or paranodal sites. Their binding—often complement‐dependent—can lead to conduction block, axonal injury, and subsequent functional deficits ranging from motor impairment and ataxia to sensory disturbances, highlighting the detrimental consequences of immune attack on NFASC‐mediated domains."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_fs", "start_ref": "7", "end_ref": "10"}, {"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, structural studies have revealed that NFASC possesses a horseshoe‐shaped arrangement of immunoglobulin-like domains that mediate homophilic adhesion. Alternative splicing gives rise to developmentally regulated isoforms—such as the embryonic NF166, which activates fibroblast growth factor receptor 1 (FGFR1) via critical intracellular serine residues to promote neurite outgrowth, in contrast with adult isoforms that contribute to synaptic stabilization and the organization of postsynaptic elements. These insights emphasize the dual role of NFASC in both dynamic neurite remodeling and the steady maintenance of established neural structures."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "14"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its classical roles in the nervous system, NFASC expression is also observed in non-neuronal cells. In podocytes, NFASC localizes to major cellular processes, suggesting a contribution to the intricate architecture of the glomerular filtration barrier. Furthermore, in non–small cell lung cancer (NSCLC), NFASC gene amplifications and overexpression have been linked to altered actin cytoskeletal dynamics and increased cell motility, implicating NFASC as a novel regulator of tumor cell migration and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic investigations have further underscored the critical role of NFASC in human neurodevelopment. Recessive mutations—particularly those selectively impacting the glial NF155 isoform—result in a spectrum of pathologies characterized by central and peripheral demyelination, neurodevelopmental delay, and, in some cases, auditory neuropathy spectrum disorder. Such findings demonstrate that a loss or marked reduction of NF155 impairs paranodal junction formation at the node of Ranvier, thereby contributing to the severe neurological phenotypes observed."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": ""}]}]}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Emily K Mathey, Tobias Derfuss, Maria K Storch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neurofascin as a novel target for autoantibody-mediated axonal injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20071053"}], "href": "https://doi.org/10.1084/jem.20071053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17846150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17846150"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Courtney Thaxton, Anilkumar M Pillai, Alaine L Pribisko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In vivo deletion of immunoglobulin domains 5 and 6 in neurofascin (Nfasc) reveals domain-specific requirements in myelinated axons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.5951-09.2010"}], "href": "https://doi.org/10.1523/JNEUROSCI.5951-09.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20371806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20371806"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jérôme J Devaux, Masaaki Odaka, Nobuhiro Yuki "}, {"type": "b", "children": [{"type": "t", "text": "Nodal proteins are target antigens in Guillain-Barré syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Peripher Nerv Syst (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1529-8027.2012.00372.x"}], "href": "https://doi.org/10.1111/j.1529-8027.2012.00372.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22462667"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22462667"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Elizabeth D Buttermore, Claire Piochon, Michael L Wallace, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pinceau organization in the cerebellum requires distinct functions of neurofascin in Purkinje and basket neurons during postnatal development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.5602-11.2012"}], "href": "https://doi.org/10.1523/JNEUROSCI.5602-11.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22492029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22492029"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Edoardo Monfrini, Letizia Straniero, Sara Bonato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neurofascin (NFASC) gene mutation causes autosomal recessive ataxia with demyelinating neuropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Parkinsonism Relat Disord (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.parkreldis.2019.02.045"}], "href": "https://doi.org/10.1016/j.parkreldis.2019.02.045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30850329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30850329"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Stephanie Efthymiou, Vincenzo Salpietro, Nancy Malintan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biallelic mutations in neurofascin cause neurodevelopmental impairment and peripheral demyelination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/brain/awz248"}], "href": "https://doi.org/10.1093/brain/awz248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31501903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31501903"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Luis Querol, Gisela Nogales-Gadea, Ricardo Rojas-Garcia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neurofascin IgG4 antibodies in CIDP associate with disabling tremor and poor response to IVIg."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/WNL.0000000000000205"}], "href": "https://doi.org/10.1212/WNL.0000000000000205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24523485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24523485"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Nobutoshi Kawamura "}, {"type": "b", "children": [{"type": "t", "text": "[Neurofascin: a novel target for combined central and peripheral demyelination]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Rinsho Shinkeigaku (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5692/clinicalneurol.54.978"}], "href": "https://doi.org/10.5692/clinicalneurol.54.978"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25672685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25672685"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jérôme J Devaux, Yumako Miura, Yuki Fukami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/WNL.0000000000002418"}], "href": "https://doi.org/10.1212/WNL.0000000000002418"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26843559"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26843559"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Emilien Delmont, Constance Manso, Luis Querol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autoantibodies to nodal isoforms of neurofascin in chronic inflammatory demyelinating polyneuropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/brain/awx124"}], "href": "https://doi.org/10.1093/brain/awx124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28575198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28575198"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Darshan Koticha, Joanne Babiarz, Noriko Kane-Goldsmith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell adhesion and neurite outgrowth are promoted by neurofascin NF155 and inhibited by NF186."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcn.2005.06.007"}], "href": "https://doi.org/10.1016/j.mcn.2005.06.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16061393"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16061393"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Katja Kirschbaum, Martin Kriebel, Eva Ursula Kranz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of non-canonical fibroblast growth factor receptor 1 (FGFR1) interaction reveals regulatory and activating domains of neurofascin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.004440"}], "href": "https://doi.org/10.1074/jbc.M109.004440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19666467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19666467"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Heli Liu, Pamela J Focia, Xiaolin He "}, {"type": "b", "children": [{"type": "t", "text": "Homophilic adhesion mechanism of neurofascin, a member of the L1 family of neural cell adhesion molecules."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.180281"}], "href": "https://doi.org/10.1074/jbc.M110.180281"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21047790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21047790"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Martin Kriebel, Jennifer Wuchter, Sabine Trinks, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neurofascin: a switch between neuronal plasticity and stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2012.01.012"}], "href": "https://doi.org/10.1016/j.biocel.2012.01.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22306302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22306302"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Laleh Sistani, Patricia Q Rodriguez, Kjell Hultenby, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kidney Int (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ki.2012.321"}], "href": "https://doi.org/10.1038/ki.2012.321"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22913984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22913984"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Johanna Samulin Erdem, Yke Jildouw Arnoldussen, Vidar Skaug, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Copy number variation, increased gene expression, and molecular mechanisms of neurofascin in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.22664"}], "href": "https://doi.org/10.1002/mc.22664"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28418179"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28418179"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jonathan L Harper, Theodore E Wilson, Ryan M Mitchell "}, {"type": "b", "children": [{"type": "t", "text": "Case report of two children with auditory neuropathy spectrum disorder related to a neurofascin (NFASC) gene variant."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Pediatr Otorhinolaryngol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ijporl.2020.109863"}], "href": "https://doi.org/10.1016/j.ijporl.2020.109863"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31945734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31945734"}]}]}]}
Synonyms	NF, NRCAML
Proteins	NFASC_HUMAN
NCBI Gene ID	23114
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NFASC has 6,453 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 126 datasets.

Click the + buttons to view associations for NFASC from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NFASC Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NFASC gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NFASC gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NFASC gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NFASC gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NFASC gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NFASC gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NFASC gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NFASC gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NFASC gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of NFASC gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NFASC gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NFASC gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with NFASC gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NFASC gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NFASC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NFASC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with NFASC gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NFASC gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NFASC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NFASC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NFASC protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NFASC protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NFASC gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NFASC gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NFASC gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NFASC gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with NFASC gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by NFASC gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with NFASC gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with NFASC gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NFASC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NFASC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NFASC gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NFASC gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NFASC gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NFASC gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NFASC gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing NFASC from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with NFASC gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with NFASC gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.