{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNuclear factor erythroid‐derived 2 (NF‐E2) functions as a master regulator in hematopoietic cell lineages, particularly in megakaryocyte maturation and thrombopoiesis. In megakaryocytic cells, NF‐E2 (specifically its p45 subunit) coordinates the induction of platelet‐specific gene expression and modulates cytoprotective responses by competing with other bZIP factors such as Nrf2, thereby allowing reactive oxygen species to serve as signaling molecules during cellular maturation. In vivo and cell‐conversion studies have shown that NF‐E2—often acting together with Maf partners—can even reprogram nonhematopoietic cells into megakaryocytes, while its regulated expression is essential for proper platelet release. Moreover, NF‐E2 levels are modulated by upstream transcription factors (for example, Scl) and by proinflammatory signals (such as IL‐1β), and its function can be further fine‐tuned by post‐translational modifications including ubiquitination and sumoylation that influence its stability, subcellular localization, and DNA‐binding activity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn erythroid cells, NF‐E2 contributes to the transcriptional regulation of globin genes. It is required not only for the formation of active chromatin conformation, as evidenced by its role in facilitating chromatin looping and histone acetylation at the β‐globin locus, but also for full transcriptional activation of fetal and adult globin genes. Its DNA‐binding capacity is enhanced by sumoylation and other protein modifications, and it cooperates with other erythroid activators such as GATA‐1 and TAL1. Additionally, NF‐E2 contributes to the post‐transcriptional regulation of factors like the α‐hemoglobin stabilizing protein and modulates microRNA expression (for example, miR‐199b‐5p), further linking its activity to the fine‐tuning of erythroid differentiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAberrant NF‐E2 expression is a key hallmark of various myeloproliferative neoplasms (MPNs) and related hematologic malignancies. Elevated levels or mutant forms of NF‐E2 contribute to features such as thrombocytosis, Epo‐independent erythroid maturation, expansion of hematopoietic stem and progenitor cells, and even predisposition to leukemic transformation. Moreover, NF‐E2 overactivity—sometimes driven by dysregulated upstream signals like aberrant AML1 expression or mislocalization within the cell—can serve as both a diagnostic marker and a mechanistic driver in these disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNF‐E2 activity is further modulated by various signaling pathways and epigenetic mechanisms. In nonhematopoietic settings such as the liver, NF‐E2 directly induces the expression of regulatory microRNAs (for example, miR‐423‐5p) that perturb metabolic signaling pathways implicated in diabetes and steatosis. In addition, NF‐E2 protein levels and activity are controlled by stress‐activated kinases (like JNK), specific ubiquitination processes, and by the binding of other transcription factors such as AML1, BCL6, or even vitamin D receptor–associated elements, highlighting the multifaceted regulatory network in which NF‐E2 participates."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "26", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical roles in blood cell development, NF‐E2 also participates in extrahematopoietic processes. In the placenta, reduced NF‐E2 expression is associated with abnormal syncytiotrophoblast differentiation, altered post‐translational modifications of key regulators such as GCM1, and compromised placental vascularization, ultimately contributing to intrauterine growth restriction. Together, these observations underscore how NF‐E2’s regulatory influence extends into developmental and tissue homeostasis contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "31"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hozumi Motohashi, Momoko Kimura, Rie Fujita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2009-05-223107"}], "href": "https://doi.org/10.1182/blood-2009-05-223107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19901266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19901266"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kai B Kaufmann, Albert Gründer, Tobias Hadlich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20110540"}], "href": "https://doi.org/10.1084/jem.20110540"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22231305"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22231305"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yukako Ono, Yuhuan Wang, Hidenori Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2012-02-413617"}], "href": "https://doi.org/10.1182/blood-2012-02-413617"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22855609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22855609"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jonas S Jutzi, Ruzhica Bogeska, Gorica Nikoloski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MPN patients harbor recurrent truncating mutations in transcription factor NF-E2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20120521"}], "href": "https://doi.org/10.1084/jem.20120521"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23589569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23589569"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Matthew P McCormack, Mark A Hall, Simone M Schoenwaelder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2006-02-002188"}], "href": "https://doi.org/10.1182/blood-2006-02-002188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16763211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16763211"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Carmen Ka Yee Chuen, Karen Li, Mo Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interleukin-1beta up-regulates the expression of thrombopoietin and transcription factors c-Jun, c-Fos, GATA-1, and NF-E2 in megakaryocytic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lab Clin Med (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lab.2003.09.006"}], "href": "https://doi.org/10.1016/j.lab.2003.09.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14966463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14966463"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mauro P Avanzi, Francine Goldberg, Jennifer Davila, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rho kinase inhibition drives megakaryocyte polyploidization and proplatelet formation through MYC and NFE2 downregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Haematol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bjh.12709"}], "href": "https://doi.org/10.1111/bjh.12709"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24383889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24383889"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Tung-Liang Lee, Yu-Chiau Shyu, Ting-Yin Hsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Itch regulates p45/NF-E2 in vivo by Lys63-linked ubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2008.07.164"}], "href": "https://doi.org/10.1016/j.bbrc.2008.07.164"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18718448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18718448"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "J Perdomo, E-L Fock, G Kaur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A monopartite sequence is essential for p45 NF-E2 nuclear translocation, transcriptional activity and platelet production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Thromb Haemost (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1538-7836.2010.04058.x"}], "href": "https://doi.org/10.1111/j.1538-7836.2010.04058.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20854373"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20854373"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yea Woon Kim, Seoyeon Kim, Chul Geun Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkr253"}], "href": "https://doi.org/10.1093/nar/gkr253"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21609963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21609963"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Zhuo Zhou, Xingguo Li, Changwang Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin gene locus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.098376"}], "href": "https://doi.org/10.1074/jbc.M109.098376"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20236933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20236933"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yu-Chiau Shyu, Tung-Liang Lee, Chun-Yuan Ting, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.23.10365-10378.2005"}], "href": "https://doi.org/10.1128/MCB.25.23.10365-10378.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16287851"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16287851"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yoshiaki Onishi, Ryoiti Kiyama "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of NF-E2 in the human beta-globin locus control region before chromatin remodeling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M209612200"}], "href": "https://doi.org/10.1074/jbc.M209612200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12509425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12509425"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Zhao Guo-wei, Yang Rui-feng, Lv Xiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NF-E2: a novel regulator of alpha-hemoglobin stabilizing protein gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chin Med Sci J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1001-9294(11)60001-1"}], "href": "https://doi.org/10.1016/s1001-9294(11"}, {"type": "t", "text": "60001-1) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21232177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21232177"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yuxia Li, Hua Bai, Zhongzu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The up-regulation of miR-199b-5p in erythroid differentiation is associated with GATA-1 and NF-E2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cells (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14348/molcells.2014.2288"}], "href": "https://doi.org/10.14348/molcells.2014.2288"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24608802"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24608802"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Laurent Boulanger, Denise E Sabatino, Ellice Y Wong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Erythroid expression of the human alpha-spectrin gene promoter is mediated by GATA-1- and NF-E2-binding proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M208184200"}], "href": "https://doi.org/10.1074/jbc.M208184200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12196550"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12196550"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Wei-Hwa Lee, Ming-Hui Chung, Yu-Hui Tsai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interferon-γ suppresses activin A/NF-E2 induction of erythroid gene expression through the NF-κB/c-Jun pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00312.2013"}], "href": "https://doi.org/10.1152/ajpcell.00312.2013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24336657"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24336657"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Ashley O Yocum, Laurie A Steiner, Nancy E Seidel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A tissue-specific chromatin loop activates the erythroid ankyrin-1 promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2012-08-450262"}], "href": "https://doi.org/10.1182/blood-2012-08-450262"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22968456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22968456"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yea Woon Kim, Won Ju Yun, AeRi Kim "}, {"type": "b", "children": [{"type": "t", "text": "Erythroid activator NF-E2, TAL1 and KLF1 play roles in forming the LCR HSs in the human adult β-globin locus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2016.03.013"}], "href": "https://doi.org/10.1016/j.biocel.2016.03.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27026582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27026582"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Wei Wang, Sven Schwemmers, Elizabeth O Hexner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2009-11-254664"}], "href": "https://doi.org/10.1182/blood-2009-11-254664"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20339092"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20339092"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Julius Wehrle, Thalia S Seeger, Sven Schwemmers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcription factor nuclear factor erythroid-2 mediates expression of the cytokine interleukin 8, a known predictor of inferior outcome in patients with myeloproliferative neoplasms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.2012.071183"}], "href": "https://doi.org/10.3324/haematol.2012.071183"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23445878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23445878"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Ruzhica Bogeska, Heike L Pahl "}, {"type": "b", "children": [{"type": "t", "text": "Elevated nuclear factor erythroid-2 levels promote epo-independent erythroid maturation and recapitulate the hematopoietic stem cell and common myeloid progenitor expansion observed in polycythemia vera patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells Transl Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5966/sctm.2012-0046"}], "href": "https://doi.org/10.5966/sctm.2012-0046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23341442"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23341442"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Alessandro Di Tullio, Diana Passaro, Kevin Rouault-Pierre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cell Reports (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stemcr.2017.05.027"}], "href": "https://doi.org/10.1016/j.stemcr.2017.05.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28648895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28648895"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Gabriella D'Orazi, Alessia Garufi, Mara Cirone "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear factor erythroid 2 (NF-E2) p45-related factor 2 interferes with homeodomain-interacting protein kinase 2/p53 activity to impair solid tumors chemosensitivity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUBMB Life (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iub.2334"}], "href": "https://doi.org/10.1002/iub.2334"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32593231"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32593231"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Konrad Aumann, Anna-Verena Frey, Annette M May, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Subcellular mislocalization of the transcription factor NF-E2 in erythroid cells discriminates prefibrotic primary myelofibrosis from essential thrombocythemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2012-11-463257"}], "href": "https://doi.org/10.1182/blood-2012-11-463257"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23670178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23670178"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Weili Yang, Junpei Wang, Zhenzhen Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db16-1172"}], "href": "https://doi.org/10.2337/db16-1172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28411267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28411267"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Jonas Samuel Jutzi, Titiksha Basu, Maximilian Pellmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2018-09-875047"}], "href": "https://doi.org/10.1182/blood-2018-09-875047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30755419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30755419"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Veijo Nurminen, Antonio Neme, Jussi Ryynänen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagrm.2014.12.001"}], "href": "https://doi.org/10.1016/j.bbagrm.2014.12.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25482012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25482012"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Qing Xiao, Yinu Zhao, Jia Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NFE2/miR-423-5p/TFF1 axis regulates high glucose-induced apoptosis in retinal pigment epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Mol Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12860-019-0223-2"}], "href": "https://doi.org/10.1186/s12860-019-0223-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31455213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31455213"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Tung-Liang Lee, Yu-Chiau Shyu, Pang-Hung Hsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation of murine erythroleukemia cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0909153107"}], "href": "https://doi.org/10.1073/pnas.0909153107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19966288"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19966288"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Muhammed Kashif, Andrea Hellwig, Said Hashemolhosseini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear factor erythroid-derived 2 (Nfe2) regulates JunD DNA-binding activity via acetylation: a novel mechanism regulating trophoblast differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.289801"}], "href": "https://doi.org/10.1074/jbc.M111.289801"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22174410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22174410"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Shrey Kohli, Juliane Hoffmann, Franziska Lochmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p45 NF-E2 regulates syncytiotrophoblast differentiation by post-translational GCM1 modifications in human intrauterine growth restriction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2017.127"}], "href": "https://doi.org/10.1038/cddis.2017.127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28383551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28383551"}]}]}]}