{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNFIA‐AS1, an antisense long noncoding RNA associated with the NFIA gene, stands out as a representative example of how lncRNAs may modulate disease processes. In the context of cardiovascular disease, where atherosclerosis is a principal pathological driver, dysregulation of lncRNAs is emerging as an important factor in disease development, suggesting that molecules like NFIA‐AS1 could be pivotal in the regulation of genes involved in vascular inflammation and plaque formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nDissecting its role further, studies in glioma have revealed that NFIA‐AS1 (also referred to as RP5‐833A20.1) exerts tumor‐suppressive functions by downregulating NFIA expression. In glioma cell models, overexpression of NFIA‐AS1 leads to increased methylation of the NFIA promoter and elevates levels of microRNA‐182‐5p, ultimately inhibiting cell proliferation, arresting cell cycle progression, and inducing apoptosis. These findings implicate NFIA‐AS1 as a potential therapeutic target in glioma by counteracting pathways that promote tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n\nMoreover, comprehensive profiling studies in hormone receptor–positive breast cancer have underscored the broader relevance of noncoding RNAs in oncogenesis. Although this research primarily mapped the differential expression of various lncRNAs and microRNAs, including candidates like NFIA‐AS1, the data suggest that NFIA‐AS1 may also contribute to the molecular networks underlying breast cancer pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yan-Wei Hu, Jia-Yi Zhao, Shu-Fen Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RP5-833A20.1/miR-382-5p/NFIA-dependent signal transduction pathway contributes to the regulation of cholesterol homeostasis and inflammatory reaction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.114.304296"}], "href": "https://doi.org/10.1161/ATVBAHA.114.304296"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25265644"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25265644"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chun-Min Kang, Yan-Wei Hu, Ying Nie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA RP5-833A20.1 inhibits proliferation, metastasis and cell cycle progression by suppressing the expression of NFIA in U251 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2016.5854"}], "href": "https://doi.org/10.3892/mmr.2016.5854"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27779670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27779670"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiying Shao, Ping Huang, Lei Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA and LncRNA Expression Profiles in Human Estrogen Receptor Positive Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Lab (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7754/Clin.Lab.2018.180340"}], "href": "https://doi.org/10.7754/Clin.Lab.2018.180340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30775882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30775882"}]}]}]}