{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have revealed that the long non‐coding RNA NFIA-AS2 plays an oncogenic role in glioma. In this context, NFIA-AS2 is found to be significantly overexpressed in glioma tissues, and its elevated expression correlates with poor patient prognosis. Functionally, experimental downregulation of NFIA-AS2 reduces glioma cell proliferation, migration, and invasion while promoting apoptosis. Mechanistic studies further indicate that NFIA-AS2 acts by interacting with miR-655-3p, thereby modulating the expression of its downstream effector ZFX, an axis that contributes to tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its involvement in tumorigenesis, NFIA-AS2 has been implicated in modulating hematological traits and aerobic performance in endurance athletes. A specific polymorphism within the NFIA-AS2 gene (rs1572312:C>A) exhibits significant associations with various hematological indices, including total hemoglobin mass, plasma volume, blood volume, and erythrocyte volume. These differences, particularly observed in male cyclists, suggest that the NFIA-AS2 variant may influence oxygen transport capacity and aerobic threshold, thereby potentially affecting endurance performance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, a genome-wide association study in a cohort of southwestern American Indians has identified a novel locus associated with body mass index (BMI). Although the study primarily focused on genetic factors contributing to obesity, the discovery raises the possibility that NFIA-AS2 might also be involved in metabolic regulation and energy homeostasis. However, these potential roles in modulating adiposity remain to be further elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jun Xin, Yu-Hong Zhao, Xi-Yun Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA NFIA-AS2 promotes glioma progression through modulating the miR-655-3p/ZFX axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-020-00408-9"}], "href": "https://doi.org/10.1007/s13577-020-00408-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32779154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32779154"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jadwiga Malczewska-Lenczowska, Joanna Orysiak, Edyta Majorczyk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HIF-1α and NFIA-AS2 Polymorphisms as Potential Determinants of Total Hemoglobin Mass in Endurance Athletes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Strength Cond Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1519/JSC.0000000000003686"}], "href": "https://doi.org/10.1519/JSC.0000000000003686"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35622109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35622109"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Khushdeep Bandesh, Michael Traurig, Peng Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and characterization of the long non-coding RNA NFIA-AS2 as a novel locus for body mass index in American Indians."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Obes (Lond) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41366-023-01278-5"}], "href": "https://doi.org/10.1038/s41366-023-01278-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36806387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36806387"}]}]}]}