NFKBIE Gene

HGNC Family	Ankyrin repeat domain containing (ANKRD)
Name	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Description	The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNFKBIE encodes the NF‑κB inhibitor IκBε, a central negative regulator that normally restrains NF‑κB activation to maintain immune homeostasis. This inhibitor plays a critical role in fine‐tuning inflammatory responses to pathogens and cellular stress, with alterations in its function implicated in immunodeficiency and dysregulated responses in several disease states (see, for example."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSomatic alterations of NFKBIE have been reported in a variety of malignancies. In desmoplastic melanoma, recurrent promoter mutations of NFKBIE occur in a significant subset of cases and appear to influence oncogenic signaling in the absence of typical BRAF/NRAS mutations."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In classical Hodgkin lymphoma, hemizygous frameshift and splicing mutations result in truncated IκBε proteins that fail to control NF‑κB nuclear activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similar loss‐of–function alterations are observed in chronic lymphocytic leukemia where NFKBIE deletions augment p65 phosphorylation and nuclear translocation, thereby promoting malignant cell proliferation, migration, and even resistance to targeted therapies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in oncogenesis, genetic polymorphisms in NFKBIE have been associated with autoimmune disorders such as rheumatoid arthritis. Non‐synonymous variants and candidate regulatory single nucleotide polymorphisms have been linked to enhanced NF‑κB activity and altered cytokine production that contribute to disease susceptibility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Complementary functional studies have demonstrated that higher basal expression of NFKBIE may confer resistance to environmental toxicants, as evidenced by increased resilience to arsenite toxicity"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", while antioxidant interventions such as vitamin C can prevent cigarette smoke–induced degradation of IκBε, thereby limiting NF‑κB–mediated inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Moreover, specificity in NF‑κB regulation is further refined by interactions with phosphatase complexes; for instance, SAPS domain subunits of protein phosphatase 6 directly associate with IκBε, helping to govern its stability and downstream signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its established role in immune cell signaling and tumor biology, IκBε is also important in non-immune contexts. At the feto-maternal interface, for example, molecules such as galectin‑1 modulate LPS‐induced upregulation of IκBε in decidua cells, thereby contributing to an anti-inflammatory milieu essential for fetal tolerance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " In parallel, alterations in NF‑κB activation—whether in response to ionizing radiation–induced oxidative stress"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "or in the genetic predisposition to invasive bacterial infections"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "—underscore the multifaceted contributions of NFKBIE to both physiological regulation and disease pathogenesis.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Stephen J Chapman, Chiea C Khor, Fredrik O Vannberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IkappaB genetic polymorphisms and invasive pneumococcal disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Crit Care Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1164/rccm.200702-169OC"}], "href": "https://doi.org/10.1164/rccm.200702-169OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17463416"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17463416"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "R Dieguez-Gonzalez, S Akar, M Calaza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Rheum Dis (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/ard.2007.087304"}], "href": "https://doi.org/10.1136/ard.2007.087304"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18434448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18434448"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "A Hunter Shain, Maria Garrido, Thomas Botton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.3382"}], "href": "https://doi.org/10.1038/ng.3382"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26343386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26343386"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Florian Emmerich, Sebastian Theurich, Michael Hummel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.1454"}], "href": "https://doi.org/10.1002/path.1454"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14595753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14595753"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Larry Mansouri, Lesley-Ann Sutton, Viktor Ljungström, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20142009"}], "href": "https://doi.org/10.1084/jem.20142009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25987724"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25987724"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Larry Mansouri, Daniel Noerenberg, Emma Young, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2016-03-704528"}], "href": "https://doi.org/10.1182/blood-2016-03-704528"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27670424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27670424"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Alice Bonato, Supriya Chakraborty, Riccardo Bomben, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NFKBIE mutations are selected by the tumor microenvironment and contribute to immune escape in chronic lymphocytic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41375-024-02224-8"}], "href": "https://doi.org/10.1038/s41375-024-02224-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38486128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38486128"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jessica Bordini, Chiara Lenzi, Michela Frenquelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IκBε deficiency accelerates disease development in chronic lymphocytic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41375-024-02236-4"}], "href": "https://doi.org/10.1038/s41375-024-02236-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38575671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38575671"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Keiko Myouzen, Yuta Kochi, Yukinori Okada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional variants in NFKBIE and RTKN2 involved in activation of the NF-κB pathway are associated with rheumatoid arthritis in Japanese."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1002949"}], "href": "https://doi.org/10.1371/journal.pgen.1002949"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23028356"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23028356"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Hitoshi Imamura, Sawako Yoshina, Katsunori Ikari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impaired NFKBIE gene function decreases cellular uptake of methotrexate by down-regulating SLC19A1 expression in a human rheumatoid arthritis cell line."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Rheumatol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/14397595.2015.1112481"}], "href": "https://doi.org/10.3109/14397595.2015.1112481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26587663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26587663"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Elena V Komissarova, Ping Li, Ahmed N Uddin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene expression levels in normal human lymphoblasts with variable sensitivities to arsenite: identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Toxicol Appl Pharmacol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.taap.2007.09.004"}], "href": "https://doi.org/10.1016/j.taap.2007.09.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17976673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17976673"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Bannhi Das, Palash C Maity, Alok K Sil "}, {"type": "b", "children": [{"type": "t", "text": "Vitamin C forestalls cigarette smoke induced NF-κB activation in alveolar epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Toxicol Lett (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.toxlet.2013.04.009"}], "href": "https://doi.org/10.1016/j.toxlet.2013.04.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23615073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23615073"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Bjarki Stefansson, David L Brautigan "}, {"type": "b", "children": [{"type": "t", "text": "Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M601772200"}], "href": "https://doi.org/10.1074/jbc.M601772200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16769727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16769727"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Fernando Gómez-Chávez, Violeta Castro-Leyva, Aurora Espejel-Núñez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Galectin-1 reduced the effect of LPS on the IL-6 production in decidual cells by inhibiting LPS on the stimulation of IκBζ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Reprod Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jri.2015.07.002"}], "href": "https://doi.org/10.1016/j.jri.2015.07.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26226212"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26226212"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Sara J Schonfeld, Parveen Bhatti, Elizabeth E Brown, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Causes Control (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10552-010-9613-7"}], "href": "https://doi.org/10.1007/s10552-010-9613-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20711808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20711808"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Lene F Lundbo, Zitta Barrella Harboe, Louise N Clausen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic Variation in NFKBIE Is Associated With Increased Risk of Pneumococcal Meningitis in Children."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2015.11.048"}], "href": "https://doi.org/10.1016/j.ebiom.2015.11.048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26870821"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26870821"}]}]}]}
Synonyms	IKBE
Proteins	IKBE_HUMAN
NCBI Gene ID	4794
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NFKBIE has 7,567 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 121 datasets.

Click the + buttons to view associations for NFKBIE from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NFKBIE Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NFKBIE gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NFKBIE gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NFKBIE gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NFKBIE gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NFKBIE gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NFKBIE gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NFKBIE gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NFKBIE gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NFKBIE gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NFKBIE gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NFKBIE gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with NFKBIE protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with NFKBIE gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NFKBIE gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NFKBIE gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NFKBIE gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NFKBIE gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NFKBIE protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NFKBIE protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing NFKBIE protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing NFKBIE protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NFKBIE protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NFKBIE protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing NFKBIE protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NFKBIE gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NFKBIE gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NFKBIE gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NFKBIE gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with NFKBIE gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of NFKBIE protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by NFKBIE gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with NFKBIE gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with NFKBIE gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NFKBIE gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NFKBIE gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NFKBIE gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NFKBIE gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NFKBIE gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NFKBIE gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NFKBIE gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.