NFS1 Gene

Name	NFS1 cysteine desulfurase
Description	Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNFS1 is a highly conserved L‐cysteine desulfurase that catalyzes the mobilization of sulfur from L-cysteine to generate a persulfide intermediate required for iron-sulfur (Fe-S) cluster assembly. In mitochondria, it forms the core of a multiprotein complex with partners such as ISD11, acyl carrier protein (ACP), and scaffold protein ISCU, and is further regulated by the allosteric activator frataxin (FXN). High-resolution structural and biochemical studies have revealed an unexpected architecture of the NFS1–ISD11–ACP complex, defined stoichiometries that support the formation of multiple Fe-S cluster assembly centers, and distinct mechanisms by which substrate access and cofactor binding are controlled. These studies also show that loss of NFS1 in human cells leads to impaired maturation of both mitochondrial and cytosolic Fe-S proteins, accompanied by growth arrest and altered mitochondrial morphology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its central mitochondrial function, NFS1 is also distributed to the cytosol and nucleus where it donates sulfur for additional biosynthetic pathways. In these locales, it interacts with the sulfur relay protein MOCS3 to facilitate molybdenum cofactor (Moco) biosynthesis and tRNA thiolation, with evidence supporting that a cytosolic isoform of NFS1 is active and essential for these processes. Such dual localization and function underscore the enzyme’s critical role in sulfur trafficking across distinct cellular compartments."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent investigations in cancer biology have further revealed that NFS1 activity is a determining factor in cellular responses to oxidative stress. In lung adenocarcinomas, where tissue oxygen levels are elevated, high NFS1 expression is selected to maintain Fe-S cluster integrity and thereby protect cells from ferroptosis. In parallel, studies in colorectal cancer demonstrate that NFS1 deficiency increases reactive oxygen species production and sensitizes tumor cells to chemotherapeutic agents by triggering multiple programmed cell death pathways. These findings highlight a role for NFS1 not only in metabolic maintenance but also in dictating sensitivity to oxidative insults in tumor cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional biochemical and structural analyses have delineated a regulatory network in which NFS1’s activity is fine-tuned by its interactions with multiple partners. Engagement with ISD11 and FXN, as well as dynamic associations with ferredoxins, not only optimize the desulfurase reaction but also safeguard the stability of Fe-S cluster scaffold proteins. For example, interactions between NFS1 and ISCU influence the degradation rate of Fe-S assembly components, while specific regions of ISD11 are essential for forming a stable, active complex. Comparative studies even reveal that human NFS1 shares conserved binding sites with its bacterial orthologue, underscoring the evolutionary conservation of its role in sulfur transfer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Annette Biederbick, Oliver Stehling, Ralf Rösser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00112-06"}], "href": "https://doi.org/10.1128/MCB.00112-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16847322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16847322"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kai Cai, Ronnie O Frederick, Jin Hae Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.482042"}], "href": "https://doi.org/10.1074/jbc.M113.482042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23940031"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23940031"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Oleksandr Gakh, Wasantha Ranatunga, Douglas Y Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.738542"}], "href": "https://doi.org/10.1074/jbc.M116.738542"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27519411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27519411"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Seth A Cory, Jonathan G Van Vranken, Edward J Brignole, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1702849114"}], "href": "https://doi.org/10.1073/pnas.1702849114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28634302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28634302"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Martin Bühning, Martin Friemel, Silke Leimkühler "}, {"type": "b", "children": [{"type": "t", "text": "Functional Complementation Studies Reveal Different Interaction Partners of Escherichia coli IscS and Human NFS1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.biochem.7b00627"}], "href": "https://doi.org/10.1021/acs.biochem.7b00627"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28766335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28766335"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nicholas G Fox, Alain Martelli, Joseph F Nabhan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochimie (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biochi.2018.07.012"}], "href": "https://doi.org/10.1016/j.biochi.2018.07.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30031876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30031876"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Nicholas G Fox, Xiaodi Yu, Xidong Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-09989-y"}], "href": "https://doi.org/10.1038/s41467-019-09989-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31101807"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31101807"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Kuanyu Li, Wing-Hang Tong, Robert M Hughes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M600582200"}], "href": "https://doi.org/10.1074/jbc.M600582200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16527810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16527810"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Zvonimir Marelja, Walter Stöcklein, Manfred Nimtz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M804064200"}], "href": "https://doi.org/10.1074/jbc.M804064200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18650437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18650437"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Adi Naamati, Neta Regev-Rudzki, Shlomi Galperin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.034694"}], "href": "https://doi.org/10.1074/jbc.M109.034694"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19720832"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19720832"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Zvonimir Marelja, Mita Mullick Chowdhury, Carsten Dosche, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The L-cysteine desulfurase NFS1 is localized in the cytosol where it provides the sulfur for molybdenum cofactor biosynthesis in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0060869"}], "href": "https://doi.org/10.1371/journal.pone.0060869"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23593335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23593335"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yannika Neukranz, Annika Kotter, Lena Beilschmidt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of the Cellular Roles of MOCS3 Identifies a MOCS3-Independent Localization of NFS1 at the Tips of the Centrosome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.biochem.8b01160"}], "href": "https://doi.org/10.1021/acs.biochem.8b01160"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30817134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30817134"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Samantha W Alvarez, Vladislav O Sviderskiy, Erdem M Terzi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature24637"}], "href": "https://doi.org/10.1038/nature24637"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29168506"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29168506"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jin-Fei Lin, Pei-Shan Hu, Yi-Yu Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Signal Transduct Target Ther (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41392-022-00889-0"}], "href": "https://doi.org/10.1038/s41392-022-00889-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35221331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35221331"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ji-Yoon Song, Jaroslaw Marszalek, Elizabeth Anne Craig "}, {"type": "b", "children": [{"type": "t", "text": "Cysteine desulfurase Nfs1 and Pim1 protease control levels of Isu, the Fe-S cluster biogenesis scaffold."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1206945109"}], "href": "https://doi.org/10.1073/pnas.1206945109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22689995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22689995"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Alok Pandey, Donna M Gordon, Jayashree Pain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frataxin directly stimulates mitochondrial cysteine desulfurase by exposing substrate-binding sites, and a mutant Fe-S cluster scaffold protein with frataxin-bypassing ability acts similarly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.525857"}], "href": "https://doi.org/10.1074/jbc.M113.525857"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24217246"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24217246"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Prasenjit Prasad Saha, Shubhi Srivastava, Praveen Kumar S K, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mapping Key Residues of ISD11 Critical for NFS1-ISD11 Subcomplex Stability: IMPLICATIONS IN THE DEVELOPMENT OF MITOCHONDRIAL DISORDER, COXPD19."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.678508"}], "href": "https://doi.org/10.1074/jbc.M115.678508"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26342079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26342079"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Kai Cai, Marco Tonelli, Ronnie O Frederick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human Mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) Both Bind Cysteine Desulfurase and Donate Electrons for Iron-Sulfur Cluster Biosynthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.biochem.6b00447"}], "href": "https://doi.org/10.1021/acs.biochem.6b00447"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28001042"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28001042"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Martin Friemel, Zvonimir Marelja, Kuanyu Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The N-Terminus of Iron-Sulfur Cluster Assembly Factor ISD11 Is Crucial for Subcellular Targeting and Interaction with l-Cysteine Desulfurase NFS1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.biochem.6b01239"}], "href": "https://doi.org/10.1021/acs.biochem.6b01239"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28271877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28271877"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Kai Cai, Ronnie O Frederick, Hesam Dashti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Architectural Features of Human Mitochondrial Cysteine Desulfurase Complexes from Crosslinking Mass Spectrometry and Small-Angle X-Ray Scattering."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2018.05.017"}], "href": "https://doi.org/10.1016/j.str.2018.05.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29983374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29983374"}]}]}]}
Synonyms	NIFS, ISCS, HUSSY-08
Proteins	NFS1_HUMAN
NCBI Gene ID	9054
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NFS1 has 6,028 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 121 datasets.

Click the + buttons to view associations for NFS1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NFS1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NFS1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NFS1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NFS1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NFS1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NFS1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NFS1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NFS1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NFS1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NFS1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of NFS1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NFS1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NFS1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with NFS1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with NFS1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NFS1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NFS1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NFS1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with NFS1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NFS1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NFS1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NFS1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing NFS1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing NFS1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NFS1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NFS1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NFS1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NFS1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NFS1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NFS1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with NFS1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NFS1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NFS1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NFS1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NFS1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for NFS1 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NFS1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NFS1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NFS1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing NFS1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with NFS1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.