NFYA Gene

Name	nuclear transcription factor Y, alpha
Description	The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNF‐YA is the sequence‐specific DNA‐binding subunit of the heterotrimeric transcription factor NF‐Y that recognizes the CCAAT box—a highly prevalent promoter motif. Early studies demonstrated that NF‐YA–containing NF‐Y complexes are distinct regulators of gene expression, directly engaging the promoter regions of key genes such as those controlling the major histocompatibility complex, cyclins, and stress‐responsive factors. NF‐YA interacts with other transcription regulators including BRCA1, Sp1, and Oct‐1 to modulate the expression of genes involved in cell‐cycle control (for example, via the cyclin B2 and Chk2 promoters), DNA repair (such as hOGG1 induction), and parathyroid hormone gene regulation. The structural basis for DNA recognition by NF‐YA—even revealing nucleosome‐like properties—has further delineated its cooperative role in recruiting coactivators and chromatin‐modifying enzymes to establish permissive transcriptional states."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its central role in basal transcription, NF‐YA plays pivotal roles in cellular differentiation and developmental programs. For instance, in intestinal epithelial (CaCo‐2) cells, NF‐YA expression increases during differentiation, driving the transcriptional activation of markers of mature enterocytes. In the hematopoietic system, elevated NF‐YA in stem‐cell–enriched bone marrow fractions promotes the expression of HOX genes, Notch‐1, and telomerase RNA—thereby enhancing self‐renewal. Similarly, NF‐YA is essential for the activation of developmental regulators, as illustrated by its direct binding to the SOX3 promoter, and it participates in stress responses by cooperating with p53 to regulate annexin A1 expression. Moreover, NF‐YA is required for the hormone‐responsive transcription of metabolic enzymes such as NAGS, linking its activity to nutritional and developmental signals."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDeregulation of NF‐YA expression, alternative splicing, and its interaction with distinct co‐factors have emerged as key events in oncogenesis and metabolic reprogramming. Genome‐wide mapping studies have revealed that NF‐YA occupies thousands of regulatory regions, often in conjunction with growth‐promoting factors, thereby activating genes involved in glycolysis, de novo lipogenesis, and cell proliferation. In several cancer models—including lung, endometrial, prostate, and colorectal carcinomas—NF‐YA overexpression or isoform switching (from a “long” to a “short” variant) correlates with aggressive tumor phenotypes and altered metabolic gene signatures. Moreover, NF‐YA’s activity can be functionally overridden by factors such as BCL11A in hemoglobin switching or modulated by pharmacological agents such as curcumin, underscoring its potential as both a prognostic biomarker and a therapeutic target in diverse human malignancies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "A Dorn, J Bollekens, A Staub, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A multiplicity of CCAAT box-binding proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (1987)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0092-8674(87)90513-7"}], "href": "https://doi.org/10.1016/0092-8674(87"}, {"type": "t", "text": "90513-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "3476205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/3476205"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wenhong Fan, Shunqian Jin, Tong Tong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110225200"}], "href": "https://doi.org/10.1074/jbc.M110225200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11777930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11777930"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yubin Ge, Tanya L Jensen, Larry H Matherly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Synergistic regulation of human cystathionine-beta-synthase-1b promoter by transcription factors NF-YA isoforms and Sp1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0167-4781(02)00509-2"}], "href": "https://doi.org/10.1016/s0167-4781(02"}, {"type": "t", "text": "00509-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12427542"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12427542"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Valentina Salsi, Giuseppina Caretti, Mark Wasner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M210065200"}], "href": "https://doi.org/10.1074/jbc.M210065200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12482752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12482752"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yiwen Peng, Nadia Jahroudi "}, {"type": "b", "children": [{"type": "t", "text": "The NFY transcription factor inhibits von Willebrand factor promoter activation in non-endothelial cells through recruitment of histone deacetylases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M213156200"}], "href": "https://doi.org/10.1074/jbc.M213156200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12511565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12511565"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jeanho Yun, Hee-Don Chae, Tae-Saeng Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M305178200"}], "href": "https://doi.org/10.1074/jbc.M305178200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12857729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12857729"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mi-Rha Lee, Soo-Hyun Kim, Hyun-Ju Cho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcription factors NF-YA regulate the induction of human OGG1 following DNA-alkylating agent methylmethane sulfonate (MMS) treatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M311132200"}], "href": "https://doi.org/10.1074/jbc.M311132200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14688259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14688259"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Taido Matsui, Yuko Katsuno, Tomoharu Inoue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Negative regulation of Chk2 expression by p53 is dependent on the CCAAT-binding transcription factor NF-Y."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M403232200"}], "href": "https://doi.org/10.1074/jbc.M403232200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15044452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15044452"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "T Jääskeläinen, J Huhtakangas, P H Mäenpää "}, {"type": "b", "children": [{"type": "t", "text": "Negative regulation of human parathyroid hormone gene promoter by vitamin D3 through nuclear factor Y."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2005.01.033"}], "href": "https://doi.org/10.1016/j.bbrc.2005.01.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15707954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15707954"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Marco Nardini, Nerina Gnesutta, Giacomo Donati, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2012.11.047"}], "href": "https://doi.org/10.1016/j.cell.2012.11.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23332751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23332751"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "M A Bevilacqua, M C Faniello, B Iovine, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcription factor NF-Y regulates differentiation of CaCo-2 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0003-9861(02)00436-8"}], "href": "https://doi.org/10.1016/s0003-9861(02"}, {"type": "t", "text": "00436-8) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12392713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12392713"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jiang Zhu, Yi Zhang, Gerard J Joe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NF-Ya activates multiple hematopoietic stem cell (HSC) regulatory genes and promotes HSC self-renewal."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0503405102"}], "href": "https://doi.org/10.1073/pnas.0503405102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16081537"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16081537"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sylvie Bannwarth, Sébastien Lainé, Aïcha Daher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2005.11.026"}], "href": "https://doi.org/10.1016/j.jmb.2005.11.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16343534"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16343534"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "E Lecona, J I Barrasa, N Olmo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of annexin A1 expression by butyrate in human colon adenocarcinoma cells: role of p53, NF-Y, and p38 mitogen-activated protein kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00650-07"}], "href": "https://doi.org/10.1128/MCB.00650-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18541673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18541673"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Kihong Lim, Hyo-Ihl Chang "}, {"type": "b", "children": [{"type": "t", "text": "O-GlcNAcylation of Sp1 interrupts Sp1 interaction with NF-Y."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2009.03.075"}], "href": "https://doi.org/10.1016/j.bbrc.2009.03.075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19302979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19302979"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Sandra Kirsch Heibel, Giselle Yvette Lopez, Maria Panglao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional regulation of N-acetylglutamate synthase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0029527"}], "href": "https://doi.org/10.1371/journal.pone.0029527"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22383952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22383952"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Joseph D Fleming, Giulio Pavesi, Paolo Benatti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NF-Y coassociates with FOS at promoters, enhancers, repetitive elements, and inactive chromatin regions, and is stereo-positioned with growth-controlling transcription factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gr.148080.112"}], "href": "https://doi.org/10.1101/gr.148080.112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23595228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23595228"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Can Dai, Cong-Xiu Miao, Xiao-Ming Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional activation of human CDCA8 gene regulated by transcription factor NF-Y in embryonic stem cells and cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.642710"}], "href": "https://doi.org/10.1074/jbc.M115.642710"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26170459"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26170459"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Paolo Benatti, Maria Luisa Chiaramonte, Mariangela Lorenzo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NF-Y activates genes of metabolic pathways altered in cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.6453"}], "href": "https://doi.org/10.18632/oncotarget.6453"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26646448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26646448"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Bin Cao, Yu Zhao, Zheng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene regulatory network construction identified NFYA as a diffuse subtype-specific prognostic factor in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2018.4519"}], "href": "https://doi.org/10.3892/ijo.2018.4519"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30106137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30106137"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Biji Chatterjee, Krishna Ghosh, Lavanya Suresh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Curcumin ameliorates PRMT5-MEP50 arginine methyltransferase expression by decreasing the Sp1 and NF-YA transcription factors in the A549 and MCF-7 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-018-3471-0"}], "href": "https://doi.org/10.1007/s11010-018-3471-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30392062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30392062"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Eugenia Bezzecchi, Mirko Ronzio, Diletta Dolfini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NF-YA Overexpression in Lung Cancer: LUSC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes10110937"}], "href": "https://doi.org/10.3390/genes10110937"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31744190"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31744190"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Nan Liu, Shuqian Xu, Qiuming Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcription factor competition at the γ-globin promoters controls hemoglobin switching."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41588-021-00798-y"}], "href": "https://doi.org/10.1038/s41588-021-00798-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33649594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33649594"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Raghavendra T K Poluri, Virginie Paquette, Éric P Allain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KLF5 and NFYA factors as novel regulators of prostate cancer cell metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocr Relat Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/ERC-20-0504"}], "href": "https://doi.org/10.1530/ERC-20-0504"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33690159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33690159"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Taijyu Satoh, Longfei Wang, Cristina Espinosa-Diez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.121.053889"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.121.053889"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34157861"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34157861"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Silvia Belluti, Valentina Semeghini, Giovanna Rigillo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative splicing of NF-YA promotes prostate cancer aggressiveness and represents a new molecular marker for clinical stratification of patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-021-02166-4"}], "href": "https://doi.org/10.1186/s13046-021-02166-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34782004"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34782004"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Fengyan Han, Lei Zhang, Shaoxia Liao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The interaction between S100A2 and KPNA2 mediates NFYA nuclear import and is a novel therapeutic target for colorectal cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-021-02116-6"}], "href": "https://doi.org/10.1038/s41388-021-02116-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34802034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34802034"}]}]}]}
Synonyms	CBF-B, CBF-A, NF-YA, HAP2
Proteins	NFYA_HUMAN
NCBI Gene ID	4800
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NFYA has 7,590 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 130 datasets.

Click the + buttons to view associations for NFYA from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NFYA Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NFYA gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NFYA gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NFYA gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NFYA gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NFYA gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NFYA gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving NFYA protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NFYA gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NFYA gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NFYA gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of NFYA gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NFYA gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NFYA gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with NFYA protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NFYA gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NFYA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NFYA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of NFYA gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing NFYA protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NFYA gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NFYA protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NFYA protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NFYA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NFYA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing NFYA protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NFYA gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NFYA gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NFYA gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NFYA gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of NFYA protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by NFYA gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with NFYA gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NFYA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NFYA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NFYA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NFYA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NFYA gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NFYA gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NFYA gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing NFYA from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.