{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNIBAN1, also known as FAM129A or C1orf24, is emerging as a stress‐responsive gene acting downstream of key adaptive pathways. In prostate cancer models, for instance, it is directly induced by the ATF4 transcription factor during an unfolded protein response, where it helps modulate feedback through PERK/eIF2α pathways to support tumor cell survival and growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in adaptive stress signaling, NIBAN1 is frequently up‐regulated in several malignancies and appears to function as a marker of early tumorigenic events. In thyroid and renal carcinogenesis, elevated NIBAN1 expression has been linked to the oxyphilic phenotype and altered mitochondrial function, while immunohistochemical and molecular analyses support its overexpression in various thyroid neoplasms."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": " Moreover, studies in thyroid carcinoma cells demonstrate that microRNA‐mediated regulation of NIBAN1 enhances proliferation and migration, and its expression in normal thyroid cells modulates autophagy in a context‐dependent manner."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond endocrine and renal tumors, NIBAN1 plays roles in regulating cell fate under stress in other pathological conditions. In an acute pancreatitis model, silencing of miR-135a—a negative regulator of NIBAN1—was shown to alleviate cell injury and inflammatory response via up-regulation of NIBAN1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In the realm of invasive cancers, studies in glioma stem cells and esophageal cancer suggest that NIBAN1 contributes to tumor cell invasion and progression, highlighting its potential as a multifaceted therapeutic target across different cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nora Pällmann, Marte Livgård, Martina Tesikova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-019-0879-2"}], "href": "https://doi.org/10.1038/s41388-019-0879-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31312022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31312022"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Alexandra G Evstafieva, Irina E Kovaleva, Maria S Shoshinova, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto's thyroiditis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Pathol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humpath.2006.06.022"}], "href": "https://doi.org/10.1016/j.humpath.2006.06.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16949643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16949643"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shin Ito, Hiroaki Fujii, Toshiharu Matsumoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequent expression of Niban in head and neck squamous cell carcinoma and squamous dysplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Head Neck (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hed.21153"}], "href": "https://doi.org/10.1002/hed.21153"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19536772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19536772"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Eva Sigstad, Elisabeth Paus, Trine Bjøro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The new molecular markers DDIT3, STT3A, ARG2 and FAM129A are not useful in diagnosing thyroid follicular tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/modpathol.2011.188"}], "href": "https://doi.org/10.1038/modpathol.2011.188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22157935"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22157935"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Gianna Carvalheira, Bruno Heidi Nozima, Janete Maria Cerutti "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-106b-mediated down-regulation of C1orf24 expression induces apoptosis and suppresses invasion of thyroid cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.4947"}], "href": "https://doi.org/10.18632/oncotarget.4947"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26317551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26317551"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Bruno Heidi Nozima, Thais Biude Mendes, Gustavo José da Silva Pereira, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "miR-135a deficiency inhibits the AR42J cells damage in cerulein-induced acute pancreatitis through targeting FAM129A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pflugers Arch (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00424-019-02329-5"}], "href": "https://doi.org/10.1007/s00424-019-02329-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31729558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31729558"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "J-W Cao, W-F Cui, H-J Zhu "}, {"type": "b", "children": [{"type": "t", "text": "The negative feedback loop FAM129A/CXCL14 aggravates the progression of esophageal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202206_29058"}], "href": "https://doi.org/10.26355/eurrev_202206_29058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35776020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35776020"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Guohao Liu, Po Zhang, Sui Chen, et al. 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