| Name | niban apoptosis regulator 3 |
| Summary |
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In other words, while the studies comprehensively detail mechanisms governing lysosome function, mitochondrial turnover, and metabolism, they do not provide any data or discussion that would clarify or define the role of NIBAN3."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marta Starcevic, Esteban C Dell'Angelica "}, {"type": "b", "children": [{"type": "t", "text": "Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M402513200"}], "href": "https://doi.org/10.1074/jbc.M402513200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15102850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15102850"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "G Salazar, B Craige, M L Styers, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Heart Circ Physiol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpheart.00752.2016"}], "href": "https://doi.org/10.1152/ajpheart.00752.2016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28526709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28526709"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lingdi Wang, Iain Scott, Lu Zhu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "General Control of Amino Acid Synthesis 5-Like 1-Mediated Acetylation of Manganese Superoxide Dismutase Regulates Oxidative Stress in Diabetic Kidney Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oxid Med Cell Longev (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/6691226"}], "href": "https://doi.org/10.1155/2021/6691226"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33680286"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33680286"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Dharendra Thapa, Paramesha Bugga, Bellina A S Mushala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GCN5L1 impairs diastolic function in mice exposed to a high fat diet by restricting cardiac pyruvate oxidation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14814/phy2.15415"}], "href": "https://doi.org/10.14814/phy2.15415"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35924321"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35924321"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Sapan J Patel, Gaurang L Trivedi, Costel C Darie, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Retrograde regulation of mitochondrial fission and epithelial to mesenchymal transition in hepatocellular carcinoma by GCN5L1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-023-02621-w"}], "href": "https://doi.org/10.1038/s41388-023-02621-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36759571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36759571"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Tingting Lv, Yu Zhang, XingZhao Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GCN5L1-mediated TFAM acetylation at K76 participates in mitochondrial biogenesis in acute kidney injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-022-03782-0"}], "href": "https://doi.org/10.1186/s12967-022-03782-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36474281"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36474281"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Kaiyuan Wu, Jizhong Zou, Michael N Sack "}, {"type": "b", "children": [{"type": "t", "text": "The endo-lysosomal regulatory protein BLOC1S1 modulates hepatic lysosomal content and lysosomal lipolysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2022.12.038"}], "href": "https://doi.org/10.1016/j.bbrc.2022.12.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36535215"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36535215"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Wenqin Xu, Xiaocui Ma, Qing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GCN5L1 regulates pulmonary surfactant production by modulating lamellar body biogenesis and trafficking in mouse alveolar epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s11658-023-00506-0"}], "href": "https://doi.org/10.1186/s11658-023-00506-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37936104"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37936104"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Jackson E Stewart, Jenna M Crawford, William E Mullen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cardiomyocyte-specific deletion of GCN5L1 reduces lysine acetylation and attenuates diastolic dysfunction in aged mice by improving cardiac fatty acid oxidation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BCJ20230421"}], "href": "https://doi.org/10.1042/BCJ20230421"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38390938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38390938"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Jiejie Zhang, Shan Wang, Haitao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis promotes cerebral ischemic injury via facilitating mitochondrial fission."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s10020-024-00948-y"}], "href": "https://doi.org/10.1186/s10020-024-00948-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39390372"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39390372"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Chenxi Yang, Ye Yang, Xiuya Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of GCN5L1 exacerbates damage in alcoholic liver disease through ferroptosis activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Liver Int (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/liv.15936"}], "href": "https://doi.org/10.1111/liv.15936"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38597373"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38597373"}]}]}]}
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| NCBI Gene ID | 199786 |
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| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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NIBAN3 has 1,165 functional associations with biological entities spanning 5 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 23 datasets.
Click the + buttons to view associations for NIBAN3 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of NIBAN3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with NIBAN3 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of NIBAN3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of NIBAN3 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with NIBAN3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by NIBAN3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with NIBAN3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with NIBAN3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with NIBAN3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of NIBAN3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of NIBAN3 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with NIBAN3 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with NIBAN3 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by NIBAN3 gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of NIBAN3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of NIBAN3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by NIBAN3 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of NIBAN3 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of NIBAN3 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of NIBAN3 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of NIBAN3 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of NIBAN3 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with NIBAN3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |