NIPSNAP1 Gene

Name	nipsnap homolog 1 (C. elegans)
Description	This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. A similar protein in mice inhibits the calcium channel TRPV6, and is also localized to the inner mitochondrial membrane where it may play a role in mitochondrial DNA maintenance. A pseudogene of this gene is located on the short arm of chromosome 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNIPSNAP1 has emerged as a pivotal mitochondrial factor that plays a fundamental role in quality control. In response to mitochondrial depolarization, NIPSNAP1 accumulates on the outer mitochondrial membrane and acts as an “eat‐me” signal by recruiting key autophagy receptors and ATG8 proteins, thereby facilitating selective autophagy (mitophagy) of damaged organelles. Loss of NIPSNAP1 function has been associated with impaired mitophagy and neurodegenerative phenotypes, underscoring its essential role in mitochondrial homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn epithelial tissues, NIPSNAP1 directly regulates calcium homeostasis by inhibiting the activity of the TRPV6 channel without affecting its surface expression. This negative regulation of TRPV6 currents has significant implications for cellular calcium signaling, and genomic inactivation of NIPSNAP1—observed in prostate cancer—suggests that its tumor suppressor properties may derive, at least in part, from its capacity to curb anti‐apoptotic TRPV6 activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its mitochondrial functions, NIPSNAP1 is also involved in neural signaling and inflammatory modulation. It interacts with neuropeptides such as nocistatin to influence pain transmission, and animal studies indicate that disruption of NIPSNAP1 abolishes the normal inhibitory effects of nocistatin on pain pathways. Moreover, reduced expression of NIPSNAP1 diminishes NF‑κB activation and decreases the production of proinflammatory cytokines, linking it to the regulation of inflammatory responses and tactile allodynia."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRegulation of NIPSNAP1 activity is further modulated by interactions with both regulatory peptides and chaperone proteins. A mitochondrial peptide (ATMLP), translated from a long noncoding RNA, binds to NIPSNAP1 and interferes with its translocation from the inner to the outer mitochondrial membrane. This interference impairs autolysosome formation, thereby contributing to the malignancy of non‐small cell lung cancer. In addition, the mitochondrial chaperone HSP60 interacts with NIPSNAP1, promoting its proper folding and stability, which underscores its broader role in mitochondrial protein quality control."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yakubu Princely Abudu, Serhiy Pankiv, Benan John Mathai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NIPSNAP1 and NIPSNAP2 Act as \"Eat Me\" Signals for Mitophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2019.03.013"}], "href": "https://doi.org/10.1016/j.devcel.2019.03.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30982665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30982665"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Joost P H Schoeber, Catalin N Topala, Kyu Pil Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Nipsnap1 as a novel auxiliary protein inhibiting TRPV6 activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pflugers Arch (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00424-008-0494-5"}], "href": "https://doi.org/10.1007/s00424-008-0494-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18392847"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18392847"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ankit Malhotra, Yoshiyuki Shibata, Ira M Hall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromosomal structural variations during progression of a prostate epithelial cell line to a malignant metastatic state inactivate the NF2, NIPSNAP1, UGT2B17, and LPIN2 genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cbt.25329"}], "href": "https://doi.org/10.4161/cbt.25329"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23792589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23792589"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Emiko Okuda-Ashitaka, Toshiaki Minami, Shingo Tsubouchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.271866"}], "href": "https://doi.org/10.1074/jbc.M111.271866"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22311985"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22311985"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kazuya Okamoto, Masaki Ohashi, Kana Ohno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of NIPSNAP1, a neuropeptide nocistatin-interacting protein, in inflammatory pain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pain (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1744806916637699"}], "href": "https://doi.org/10.1177/1744806916637699"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27030720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27030720"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Soh Yamamoto, Noriko Ogasawara, Keisuke Yamamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial proteins NIP-SNAP-1 and -2 are a target for the immunomodulatory activity of clarithromycin, which involves NF-κB-mediated cytokine production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.12.100"}], "href": "https://doi.org/10.1016/j.bbrc.2016.12.100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27998764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27998764"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Soh Yamamoto, Tomoya Okamoto, Noriko Ogasawara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NIP-SNAP-1 and -2 mitochondrial proteins are maintained by heat shock protein 60."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.12.133"}], "href": "https://doi.org/10.1016/j.bbrc.2016.12.133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28011268"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28011268"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hailong Pei, Yingchu Dai, Yongduo Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Tumorigenic Effect of lncRNA AFAP1-AS1 is Mediated by Translated Peptide ATMLP Under the Control of m"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " A Methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Sci (Weinh) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/advs.202300314"}], "href": "https://doi.org/10.1002/advs.202300314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36871154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36871154"}]}]}]}
Proteins	NIPS1_HUMAN
NCBI Gene ID	8508
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NIPSNAP1 has 9,312 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 116 datasets.

Click the + buttons to view associations for NIPSNAP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NIPSNAP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NIPSNAP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NIPSNAP1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NIPSNAP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NIPSNAP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NIPSNAP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NIPSNAP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NIPSNAP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NIPSNAP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NIPSNAP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of NIPSNAP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NIPSNAP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NIPSNAP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with NIPSNAP1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with NIPSNAP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NIPSNAP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NIPSNAP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NIPSNAP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of NIPSNAP1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NIPSNAP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NIPSNAP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NIPSNAP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NIPSNAP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NIPSNAP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NIPSNAP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NIPSNAP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NIPSNAP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of NIPSNAP1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by NIPSNAP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NIPSNAP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NIPSNAP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NIPSNAP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NIPSNAP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NIPSNAP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NIPSNAP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NIPSNAP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing NIPSNAP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with NIPSNAP1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of NIPSNAP1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with NIPSNAP1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing NIPSNAP1 from the GeneSigDB Published Gene Signatures dataset.