{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNKX2-1-AS1 is a long noncoding RNA implicated in cancer progression by acting as a competing endogenous RNA. In gastric cancer, its upregulation is associated with enhanced tumor proliferation, invasion, metastasis, and angiogenesis. Mechanistically, NKX2-1-AS1 functions by sponging microRNA‐145-5p, which in turn de-represses serpin family E member 1 (SERPINE1) expression. The increase in SERPINE1 subsequently activates the VEGFR-2 signaling pathway, all of which contribute to tumor progression and aggressive angiogenic behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in gastric cancer, NKX2-1-AS1 is highly expressed in lung adenocarcinoma, where it facilitates lymphangiogenesis—a key process in lymphatic metastasis. Functional studies in lung adenocarcinoma cell lines have shown that silencing NKX2-1-AS1 suppresses cell proliferation, migration, and the expression of key lymphangiogenesis-related factors. This RNA exerts its action by binding to the transcription factor ERG, thereby regulating the transcription of fatty acid binding protein 4 (FABP4), which is critical for promoting tube formation in lymphatic endothelial cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fei Teng, Ju-Xiang Zhang, Yi Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA NKX2-1-AS1 promotes tumor progression and angiogenesis via upregulation of SERPINE1 expression and activation of the VEGFR-2 signaling pathway in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12911"}], "href": "https://doi.org/10.1002/1878-0261.12911"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33512745"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33512745"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ting Tao, Hui Chen, Qimei Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NKX2-1-AS1 promotes the lymphangiogenesis of lung adenocarcinoma through regulation of ERG-mediated FABP4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tissue Cell (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tice.2024.102314"}], "href": "https://doi.org/10.1016/j.tice.2024.102314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38309204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38309204"}]}]}]}