NKX2-4 Gene

HGNC Family	Homeoboxes
Name	NK2 homeobox 4
Synonyms	NKX2D, NKX2.4
Proteins	NKX24_HUMAN
NCBI Gene ID	644524
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NKX2-4 has 1,000 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 44 datasets.

Click the + buttons to view associations for NKX2-4 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NKX2-4 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference:

	Dataset	Summary
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NKX2-4 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NKX2-4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CHEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NKX2-4 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	CHEA Transcription Factor Targets	transcription factors binding the promoter of NKX2-4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	CHEA Transcription Factor Targets 2022	transcription factors binding the promoter of NKX2-4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NKX2-4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NKX2-4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NKX2-4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by NKX2-4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NKX2-4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NKX2-4 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NKX2-4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NKX2-4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing NKX2-4 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing NKX2-4 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of NKX2-4 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of NKX2-4 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of NKX2-4 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NKX2-4 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of NKX2-4 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Viral Infections	virus perturbations changing expression of NKX2-4 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
	GO Biological Process Annotations	biological processes involving NKX2-4 gene from the curated GO Biological Process Annotations dataset.
	GO Biological Process Annotations 2023	biological processes involving NKX2-4 gene from the curated GO Biological Process Annotations 2023 dataset.
	GO Cellular Component Annotations	cellular components containing NKX2-4 protein from the curated GO Cellular Component Annotations dataset.
	GO Cellular Component Annotations 2023	cellular components containing NKX2-4 protein from the curated GO Cellular Component Annotations 2023 dataset.
	GO Molecular Function Annotations	molecular functions performed by NKX2-4 gene from the curated GO Molecular Function Annotations dataset.
	GO Molecular Function Annotations 2023	molecular functions performed by NKX2-4 gene from the curated GO Molecular Function Annotations 2023 dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of NKX2-4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Gene Expression Profiles 2023	tissues with high or low expression of NKX2-4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	cell lines with high or low expression of NKX2-4 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
	InterPro Predicted Protein Domain Annotations	protein domains predicted for NKX2-4 protein from the InterPro Predicted Protein Domain Annotations dataset.
	JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of NKX2-4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
	Kinase Library Serine Threonine Kinome Atlas	kinases that phosphorylate NKX2-4 protein from the Kinase Library Serine Threonine Atlas dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of NKX2-4 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles	cell lines with NKX2-4 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.
	LOCATE Predicted Protein Localization Annotations	cellular components predicted to contain NKX2-4 protein from the LOCATE Predicted Protein Localization Annotations dataset.
	MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of NKX2-4 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	cell types and tissues with high or low DNA methylation of NKX2-4 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
	Roadmap Epigenomics Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NKX2-4 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
	Sanger Dependency Map Cancer Cell Line Proteomics	cell lines associated with NKX2-4 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.
	TargetScan Predicted Conserved microRNA Targets	microRNAs regulating expression of NKX2-4 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
	TargetScan Predicted Nonconserved microRNA Targets	microRNAs regulating expression of NKX2-4 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
	TCGA Signatures of Differentially Expressed Genes for Tumors	tissue samples with high or low expression of NKX2-4 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores	tissues co-occuring with NKX2-4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.