| Name | neuroligin 3 |
| Description | This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNeuroligin‐3 (NLGN3) is a postsynaptic cell‐adhesion protein that plays a critical role in synaptogenesis and in maintaining the balance between excitatory and inhibitory signaling in the brain. Studies have shown that NLGN3 interacts trans‐synaptically with presynaptic neurexins to assemble and stabilize functional synapses. Genetic investigations in individuals with autism spectrum disorders have repeatedly implicated mutations in NLGN3—including well‐characterized missense changes (e.g., R451C and R471C) which impair protein folding, trafficking, and dimerization—in disrupting synaptic communication and network synchrony. Such mutations are thought to induce endoplasmic reticulum retention and trigger stress responses that compromise synaptic maturation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its central synaptic role, NLGN3 can be released into the extracellular environment where it functions as a regulator of tumor growth. In high‐grade gliomas, neuronally secreted NLGN3 stimulates oncogenic signaling cascades (notably the PI3K–mTOR and ERK pathways), thereby promoting tumor cell proliferation and invasion. Similar oncogenic roles have been reported in neuroblastoma, where increased NLGN3 expression is associated with enhanced cell cycle progression and growth, underscoring its function as an activity‐dependent mitogen in the tumor microenvironment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these roles, NLGN3 influences diverse peripheral and neuroprotective functions. For example, autism‐associated NLGN3 mutations (such as R451C) not only disrupt central synaptic function but also lead to gastrointestinal abnormalities by altering enteric neuron populations and gut microbiota. Moreover, NLGN3 has been implicated in neuroprotection, as it activates Akt–mTOR signaling pathways that mitigate ischemia–reperfusion injury in neuronal cells. Structural analyses further reveal that NLGN3 exhibits distinct dimerization and assembly properties compared with other neuroligins, and loss‐of‐function variants have been associated with impaired neuritogenesis in gonadotropin‐releasing hormone neurons—thus broadening its impact on neurodevelopmental as well as peripheral disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "24", "end_ref": "30"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Stéphane Jamain, Hélène Quach, Catalina Betancur, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Altered synchrony and connectivity in neuronal networks expressing an autism-related mutation of neuroligin 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2009.04.062"}], "href": "https://doi.org/10.1016/j.neuroscience.2009.04.062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19406211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19406211"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Andreas Pampanos, Konstantina Volaki, Emmanuel Kanavakis, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Folding anomalies of neuroligin3 caused by a mutation in the alpha/beta-hydrolase fold domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chem Biol Interact (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cbi.2010.03.012"}], "href": "https://doi.org/10.1016/j.cbi.2010.03.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20227402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20227402"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jindan Yu, Xue He, Dan Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A sex-specific association of common variants of neuroligin genes (NLGN3 and NLGN4X) with autism spectrum disorders in a Chinese Han cohort."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Behav Brain Funct (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1744-9081-7-13"}], "href": "https://doi.org/10.1186/1744-9081-7-13"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21569590"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21569590"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Alexandros Poulopoulos, Tolga Soykan, Liam P Tuffy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Homodimerization and isoform-specific heterodimerization of neuroligins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20120808"}], "href": "https://doi.org/10.1042/BJ20120808"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22671294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22671294"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "D M Avdjieva-Tzavella, T P Todorov, A P Todorova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of the genes encoding neuroligins NLGN3 and NLGN4 in Bulgarian patients with autism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Couns (2012)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23431752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23431752"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Konstantina Volaki, Andreas Pampanos, Sophia Kitsiou-Tzeli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation screening in the Greek population and evaluation of NLGN3 and NLGN4X genes causal factors for autism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Psychiatr Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/YPG.0b013e3283643644"}], "href": "https://doi.org/10.1097/YPG.0b013e3283643644"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23851596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23851596"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xiaojuan Xu, Zhengmao Hu, Lusi Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Not all neuroligin 3 and 4X missense variants lead to significant functional inactivation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Behav (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/brb3.793"}], "href": "https://doi.org/10.1002/brb3.793"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28948087"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28948087"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Monika Sledziowska, James Galloway, Stéphane J Baudouin "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for a Contribution of the Nlgn3/Cyfip1/Fmr1 Pathway in the Pathophysiology of Autism Spectrum Disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2019.10.011"}], "href": "https://doi.org/10.1016/j.neuroscience.2019.10.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31705895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31705895"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Le Wang, Vincent R Mirabella, Rujia Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41380-022-01834-x"}], "href": "https://doi.org/10.1038/s41380-022-01834-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36280753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36280753"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Humsa S Venkatesh, Tessa B Johung, Viola Caretti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2015.04.012"}], "href": "https://doi.org/10.1016/j.cell.2015.04.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25913192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25913192"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Humsa S Venkatesh, Lydia T Tam, Pamelyn J Woo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature24014"}], "href": "https://doi.org/10.1038/nature24014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28959975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28959975"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Suzanne Hosie, Melina Ellis, Mathusi Swaminathan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autism Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/aur.2127"}], "href": "https://doi.org/10.1002/aur.2127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31119867"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31119867"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Zuoqing Li, Wenzong Gao, Yingchun Fei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NLGN3 promotes neuroblastoma cell proliferation and growth through activating PI3K/AKT pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Pharmacol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejphar.2019.172423"}], "href": "https://doi.org/10.1016/j.ejphar.2019.172423"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31150649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31150649"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yin Wang, Yuan-Yuan Liu, Min-Bin Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuronal-driven glioma growth requires Gαi1 and Gαi3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.61452"}], "href": "https://doi.org/10.7150/thno.61452"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34373757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34373757"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Jie Li, Bin Zhang, Zishan Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-024-02954-8"}], "href": "https://doi.org/10.1186/s13046-024-02954-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38254206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38254206"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Martina Landini, Ivan Merelli, M Elisabetta Raggi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association Analysis of Noncoding Variants in Neuroligins 3 and 4X Genes with Autism Spectrum Disorder in an Italian Cohort."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms17101765"}], "href": "https://doi.org/10.3390/ijms17101765"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27782075"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27782075"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Matías A Medina, Víctor M Andrade, Mario O Caracci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wnt/β-catenin signaling stimulates the expression and synaptic clustering of the autism-associated Neuroligin 3 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41398-018-0093-y"}], "href": "https://doi.org/10.1038/s41398-018-0093-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29503438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29503438"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Yanhong Li, Hui Liu, Yubin Dong "}, {"type": "b", "children": [{"type": "t", "text": "Significance of neurexin and neuroligin polymorphisms in regulating risk of Hirschsprung's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Investig Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jim-2017-000623"}], "href": "https://doi.org/10.1136/jim-2017-000623"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29622757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29622757"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Zhenzhen Zhang, Mengzhuo Hou, Huaxing Ou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Endocrinol (Lausanne) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fendo.2022.1067529"}], "href": "https://doi.org/10.3389/fendo.2022.1067529"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36479216"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36479216"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Roberto Oleari, Antonella Lettieri, Stefano Manzini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autism-linked NLGN3 is a key regulator of gonadotropin-releasing hormone deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Model Mech (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dmm.049996"}], "href": "https://doi.org/10.1242/dmm.049996"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36810932"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36810932"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Zhi-Guo Chen, Xin Shi, Xian-Xian Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuron-secreted NLGN3 ameliorates ischemic brain injury via activating Gαi1/3-Akt signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-023-06219-8"}], "href": "https://doi.org/10.1038/s41419-023-06219-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37880221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37880221"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Tamara Diamanti, Laura Trobiani, Lorenza Mautone, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/tra.12930"}], "href": "https://doi.org/10.1111/tra.12930"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38272450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38272450"}]}]}]}
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| Synonyms | HNL3 |
| Proteins | NLGN3_HUMAN |
| NCBI Gene ID | 54413 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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NLGN3 has 4,776 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 104 datasets.
Click the + buttons to view associations for NLGN3 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of NLGN3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of NLGN3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of NLGN3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of NLGN3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of NLGN3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of NLGN3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of NLGN3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of NLGN3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of NLGN3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of NLGN3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with NLGN3 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of NLGN3 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of NLGN3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of NLGN3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of NLGN3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing NLGN3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing NLGN3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with NLGN3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with NLGN3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of NLGN3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with NLGN3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with NLGN3 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with NLGN3 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by NLGN3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving NLGN3 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with NLGN3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with NLGN3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with NLGN3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with NLGN3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with NLGN3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at NLGN3 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of NLGN3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of NLGN3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing NLGN3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with NLGN3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with NLGN3 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of NLGN3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with NLGN3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing NLGN3 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of NLGN3 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of NLGN3 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of NLGN3 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of NLGN3 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of NLGN3 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving NLGN3 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving NLGN3 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving NLGN3 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing NLGN3 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing NLGN3 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing NLGN3 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by NLGN3 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by NLGN3 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by NLGN3 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of NLGN3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of NLGN3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of NLGN3 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of NLGN3 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of NLGN3 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of NLGN3 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of NLGN3 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of NLGN3 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for NLGN3 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with NLGN3 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by NLGN3 gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for NLGN3 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of NLGN3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways | pathways involving NLGN3 protein from the KEGG Pathways dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of NLGN3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of NLGN3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with NLGN3 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of NLGN3 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of NLGN3 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing NLGN3 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain NLGN3 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by NLGN3 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting NLGN3 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of NLGN3 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by NLGN3 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of NLGN3 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of NLGN3 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| OMIM Gene-Disease Associations | phenotypes associated with NLGN3 gene from the curated OMIM Gene-Disease Associations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for NLGN3 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of NLGN3 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of NLGN3 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving NLGN3 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving NLGN3 protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2024 | pathways involving NLGN3 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of NLGN3 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of NLGN3 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at NLGN3 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of NLGN3 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of NLGN3 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| SynGO Synaptic Gene Annotations | synaptic terms associated with NLGN3 gene from the SynGO Synaptic Gene Annotations dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of NLGN3 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of NLGN3 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of NLGN3 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of NLGN3 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of NLGN3 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of NLGN3 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of NLGN3 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of NLGN3 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with NLGN3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with NLGN3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving NLGN3 protein from the WikiPathways Pathways 2024 dataset. | |
