{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMetabolic reprogramming is central to tumor progression, as cancer cells adapt to increased biosynthetic and energetic demands while counteracting oxidative stress. In gastric cancer, for example, dysregulation of metabolic enzymes such as ACOT7 is closely linked with aggressive disease and poor prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nMetabolic shifts in tumor cells elevate reactive oxygen species (ROS), triggering oxidative stress that can damage cells unless neutralized. In this context, NMRAL2P has been shown to drive the production of reductive mRNA, which in turn supports the synthesis of reducing agents. These reducing agents mitigate oxidative injury by quenching excess ROS, thereby assisting tumor cells in surviving under metabolically stressful conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n\nTogether, these findings underscore the dual impact of metabolic reprogramming in cancer—where altered lipid metabolism (exemplified by ACOT7 activity) and enhanced anti-oxidative mechanisms (mediated by NMRAL2P) converge to promote tumor survival and growth. Understanding such mechanisms is critical for the development of novel therapeutic approaches designed to target tumor metabolic vulnerabilities."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Huiqin Feng, Xiaojian Liu "}, {"type": "b", "children": [{"type": "t", "text": "Interaction between ACOT7 and LncRNA NMRAL2P via Methylation Regulates Gastric Cancer Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Yonsei Med J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3349/ymj.2020.61.6.471"}], "href": "https://doi.org/10.3349/ymj.2020.61.6.471"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32469171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32469171"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qian Nie, Huan Cao, JianWang Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA NMRAL2P promotes glycolysis and reduces ROS in head and neck tumors by interacting with the ENO1 protein and promoting GPX2 transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.16140"}], "href": "https://doi.org/10.7717/peerj.16140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37810778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37810778"}]}]}]}