NOC2L Gene

HGNC Family	Protein phosphatase 1 regulatory subunits (PPP1R)
Name	nucleolar complex associated 2 homolog (S. cerevisiae)
Description	Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNOC2L, also known as NIR or Noc2p, is a multifaceted transcriptional co‐repressor endowed with inhibitor of histone acetyltransferase (INHAT) activity. It exerts its repressive function on key transcription factors such as p53 by physically associating with them and, in collaboration with partners such as Aurora kinase B, further suppresses p53‐dependent gene expression. Indeed, overexpression of NOC2L leads to diminished p53 transcriptional activity, whereas its depletion results in enhanced expression of p53 target genes and the induction of apoptosis, underscoring its critical regulatory role in cell cycle control and tumor suppression pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in transcriptional repression, NOC2L is predominantly localized in the nucleolus where it is implicated in ribosomal biogenesis. Here, as Noc2p, it is associated with the maturation of ribosomal subunits, suggesting that it may participate in the regulation of rRNA processing. Although the precise nucleolar functions remain to be fully elucidated, this localization hints at an additional layer of regulatory complexity in coordinating gene expression and ribosome assembly."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDistinct from its protein roles, a long noncoding RNA variant designated as lncRNA NOC2L‐4.1 has been identified in cervical cancer, where its overexpression correlates with reduced levels of miR‑630. This lncRNA functions as a regulatory hub by targeting miR‑630 and modulating downstream effectors such as yes‑associated protein 1 (YAP1), thereby promoting tumor cell proliferation and migration. Moreover, in colorectal cancer, NOC2L contributes to disease progression by binding to the retinoblastoma protein (RB) through an INHAT domain motif, promoting RB deacetylation and subsequent proteasome‐mediated degradation, a process that favors unchecked cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Philip Hublitz, Natalia Kunowska, Ulrich P Mayer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NIR is a novel INHAT repressor that modulates the transcriptional activity of p53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.351205"}], "href": "https://doi.org/10.1101/gad.351205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16322561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16322561"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Liming Wu, Chi A Ma, Yongge Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.174755"}], "href": "https://doi.org/10.1074/jbc.M110.174755"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20959462"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20959462"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jianguo Wu, Ying Zhang, Yingshuang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0031692"}], "href": "https://doi.org/10.1371/journal.pone.0031692"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22363708"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22363708"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Qingwei Wang, Jin Ding, Guo Nan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA NOC2L-4.1 functions as a tumor oncogene in cervical cancer progression by regulating the miR-630/YAP1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28949"}], "href": "https://doi.org/10.1002/jcb.28949"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31099044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31099044"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yuan Li, Ling Wang, Xiaofeng Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NIR promotes progression of colorectal cancer through regulating RB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2020.118856"}], "href": "https://doi.org/10.1016/j.bbamcr.2020.118856"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32931817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32931817"}]}]}]}
Synonyms	NIR, NET15, PPP1R112
Proteins	NOC2L_HUMAN
NCBI Gene ID	26155
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NOC2L has 7,385 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 117 datasets.

Click the + buttons to view associations for NOC2L from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NOC2L Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NOC2L gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NOC2L gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NOC2L gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NOC2L gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NOC2L gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NOC2L gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NOC2L gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NOC2L gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of NOC2L gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NOC2L gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NOC2L gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with NOC2L protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NOC2L gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NOC2L gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NOC2L gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing NOC2L protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NOC2L gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NOC2L protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NOC2L protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing NOC2L protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing NOC2L protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NOC2L protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NOC2L protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NOC2L gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NOC2L gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NOC2L gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NOC2L gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of NOC2L protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with NOC2L gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NOC2L gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NOC2L gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NOC2L gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NOC2L gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NOC2L gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NOC2L gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NOC2L gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing NOC2L from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of NOC2L gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with NOC2L gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing NOC2L from the GeneSigDB Published Gene Signatures dataset.