NOPCHAP1 Gene

Name NOP protein chaperone 1
Description Enables box C/D methylation guide snoRNP complex binding activity. Involved in box C/D snoRNP assembly. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNOPCHAP1 is a dedicated cofactor for the PAQosome chaperone complex that facilitates the specific assembly of box C/D snoRNPs by selecting the core protein NOP58. Mechanistically, NOPCHAP1 directly binds the CC‐NOP domain of NOP58 and simultaneously interacts with domain II of the RUVBL1/2 AAA+ ATPases that are components of the PAQosome. This bridging activity is modulated by ATP binding, which disrupts the NOPCHAP1–RUVBL1/2 interaction, indicating a mechanism that couples the energy status of the cell with the assembly process. Notably, NOPCHAP1 binds robustly to NOP58 in both yeast and human cells but does not form significant interactions with other closely related CC‐NOP proteins such as NOP56 or PRPF31, and its absence leads to a specific decrease in NOP58 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, a separate investigation of the molecular underpinnings of sperm DNA fragmentation in infertile men focused on a network of DNA damage response genes and a long non-coding RNA (DDSR1), without reporting any functional aspects of NOPCHAP1. While this study delineated the downregulation of key DNA repair factors (BRCA1, MRE11A, RAD51, and NBN) in cases of elevated sperm DNA fragmentation, it did not implicate NOPCHAP1 in these processes, thereby underscoring the specificity of the PAQosome cofactor function described earlier."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yoann Abel, Ana C F Paiva, Jonathan Bizarro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NOPCHAP1 is a PAQosome cofactor that helps loading NOP58 on RUVBL1/2 during box C/D snoRNP biogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkaa1226"}], "href": "https://doi.org/10.1093/nar/gkaa1226"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33367824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33367824"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mina Moayeri, Shiva Irani, Marefat Ghaffari Novin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of DDSR1 Long Non-Coding RNA and Genes Involved in the DNA Damage Response in Sperm with DNA Fragmentation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s43032-024-01640-6"}], "href": "https://doi.org/10.1007/s43032-024-01640-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39014289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39014289"}]}]}]}
NCBI Gene ID 121053
API
Download Associations
Predicted Functions View NOPCHAP1's ARCHS4 Predicted Functions.
Co-expressed Genes View NOPCHAP1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View NOPCHAP1's ARCHS4 Predicted Functions.

Functional Associations

NOPCHAP1 has 1,225 functional associations with biological entities spanning 5 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 18 datasets.

Click the + buttons to view associations for NOPCHAP1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of NOPCHAP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
Carcinogenome Chemical Perturbation Carcinogenicity Signatures small molecule perturbations changing expression of NOPCHAP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of NOPCHAP1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
CM4AI U2OS Cell Map Protein Localization Assemblies assemblies containing NOPCHAP1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
GO Biological Process Annotations 2025 biological processes involving NOPCHAP1 gene from the curated GO Biological Process Annotations2025 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by NOPCHAP1 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of NOPCHAP1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with NOPCHAP1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of NOPCHAP1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of NOPCHAP1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of NOPCHAP1 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of NOPCHAP1 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of NOPCHAP1 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of NOPCHAP1 gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of NOPCHAP1 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of NOPCHAP1 gene from the RummaGEO Gene Perturbation Signatures dataset.
Sci-Plex Drug Perturbation Signatures drug perturbations changing expression of NOPCHAP1 gene from the Sci-Plex Drug Perturbation Signatures dataset.
Tahoe Therapeutics Tahoe 100M Perturbation Atlas drug perturbations changing expression of NOPCHAP1 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.