NOX1 Gene

Name	NADPH oxidase 1
Description	This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNOX1 is a key catalytic subunit of the NADPH oxidase family that drives the regulated production of reactive oxygen species (ROS) in vascular cells, thereby contributing to oxidative stress and inflammatory signaling. In arterial tissues, NOX1‐derived ROS are implicated in the endothelial dysfunction and vascular inflammation underlying arterial remodeling and atherogenesis in conditions such as hypertension, diabetes, and hypercholesterolemia. Moreover, NOX1 activity is tightly controlled by its interactions with regulatory subunits and small GTPases (e.g., Rac1), which fine‐tune redox‐dependent signaling events in vascular smooth muscle and immune cells that favor proinflammatory responses and lesion formation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn epithelial tissues, NOX1 plays an essential role in maintaining mucosal homeostasis and promoting wound repair. High levels of NOX1 expression in colon crypts and its responsiveness to pro‐inflammatory mediators such as interferon‐γ and annexin A1 support its function in epithelial cell differentiation, migration, and barrier integrity. In addition, environmental stressors (for example, UVA irradiation or serum withdrawal) stimulate NOX1 activity via calcium and GTPase–dependent pathways, thereby eliciting localized redox signals that reinforce mucosal healing and adaptive responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond normal tissue physiology, aberrant up‐regulation and dysregulated activation of NOX1 are linked to malignant transformation and tumor progression. In cancer models of the colon and prostate, increased NOX1 expression enhances ROS–mediated signal transduction pathways that promote cell proliferation, invasion, angiogenesis, and metabolic reprogramming. Oncogenic stimuli—including Ras activation and c‐Src signaling—further augment NOX1 activity by modulating its interactions with activator proteins and facilitating structures such as invadopodia, which underlie extracellular matrix degradation and metastatic spread."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lula L Hilenski, Roza E Clempus, Mark T Quinn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.ATV.0000112024.13727.2c"}], "href": "https://doi.org/10.1161/01.ATV.0000112024.13727.2c"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14670934"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14670934"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rashmi K Ambasta, Pravir Kumar, Kathy K Griendling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M406486200"}], "href": "https://doi.org/10.1074/jbc.M406486200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15322091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15322091"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Guangjie Cheng, Becky A Diebold, Yasmin Hughes, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.171.1.299"}], "href": "https://doi.org/10.4049/jimmunol.171.1.299"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12817011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12817011"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Guangjie Cheng, J David Lambeth "}, {"type": "b", "children": [{"type": "t", "text": "NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M305968200"}], "href": "https://doi.org/10.1074/jbc.M305968200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14617635"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14617635"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Seung Bum Lee, In Hwa Bae, Yun Soo Bae, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Rhinovirus-induced barrier dysfunction in polarized airway epithelial cells is mediated by NADPH oxidase 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02074-10"}], "href": "https://doi.org/10.1128/JVI.02074-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21507984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21507984"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Giovanna Leoni, Ashfaqul Alam, Philipp-Alexander Neumann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI65831"}], "href": "https://doi.org/10.1172/JCI65831"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23241962"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23241962"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "So Dug Lim, Carrie Sun, J David Lambeth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased Nox1 and hydrogen peroxide in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pros.20137"}], "href": "https://doi.org/10.1002/pros.20137"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15389790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15389790"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Kei Miyano, Noriko Ueno, Ryu Takeya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M513665200"}], "href": "https://doi.org/10.1074/jbc.M513665200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16762923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16762923"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Y Adachi, Y Shibai, J Mitsushita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2008.133"}], "href": "https://doi.org/10.1038/onc.2008.133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18454176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18454176"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Davide Gianni, Ben Bohl, Sara A Courtneidge, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "HIF-1 alpha signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2010.03.008"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2010.03.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20347035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20347035"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Davide Gianni, Nicolas Taulet, Céline DerMardirossian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E10-08-0685"}], "href": "https://doi.org/10.1091/mbc.E10-08-0685"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20943948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20943948"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Weiqin Lu, Yumin Hu, Gang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.1001326"}], "href": "https://doi.org/10.1371/journal.pbio.1001326"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22589701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22589701"}]}]}]}
Synonyms	GP91-2, NOH1, NOH-1
Proteins	NOX1_HUMAN
NCBI Gene ID	27035
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NOX1 has 7,700 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 111 datasets.

Click the + buttons to view associations for NOX1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NOX1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NOX1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NOX1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NOX1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NOX1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NOX1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NOX1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NOX1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NOX1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of NOX1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NOX1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NOX1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with NOX1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NOX1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NOX1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NOX1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with NOX1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of NOX1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NOX1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NOX1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NOX1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NOX1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NOX1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NOX1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NOX1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NOX1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NOX1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by NOX1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for NOX1 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NOX1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NOX1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NOX1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NOX1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NOX1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NOX1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NOX1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	GAD Gene-Disease Associations	diseases associated with NOX1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with NOX1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of NOX1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with NOX1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing NOX1 from the GeneSigDB Published Gene Signatures dataset.