{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn this study on atrial fibrillation complicated by valvular heart disease, a comprehensive transcriptomic analysis was performed that identified differentially expressed mRNAs and lncRNAs. Among the lncRNAs, NPHP3-AS1 emerged as a key regulator within a constructed ceRNA network, acting through hsa‐miR‐1285‑3p to influence downstream targets such as BIRC5—a gene implicated in apoptosis regulation—thereby linking non‐coding RNA modulation to the pathological progression of AF-VHD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Dis primis duis mauris potenti non at sociosqu ultricies massa. Detailed bioinformatics approaches, including pathway enrichment and protein-protein interaction network construction, revealed that NPHP3-AS1 not only affected BIRC5 via miRNA mediation but also was part of a broader regulatory network involving genes like GJA5, KCNJ6, and SNAP25. This network is enriched in biological processes such as ion transmembrane transport and ion channel complex formation, suggesting multifaceted roles in cardiac electrical stability and cell survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Fusce class lectus fringilla commodo sit blandit pellentesque. The integrative analysis underscored the significance of NPHP3-AS1 as a potential molecular marker and therapeutic target, given its central role in modulating miRNA activity and thus critical gene expression pathways that underlie both apoptosis and ion transport regulation in the diseased heart. These findings provide new insights into the molecular framework of AF-VHD development and highlight the importance of ceRNA networks in cardiac pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhiwei Zhao, Guiqing Liu, Haiyang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BIRC5, GAJ5, and lncRNA NPHP3-AS1 Are Correlated with the Development of Atrial Fibrillation-Valvular Heart Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Heart J (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1536/ihj.20-238"}], "href": "https://doi.org/10.1536/ihj.20-238"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33518654"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33518654"}]}]}]}