NPHP4 Gene

Name	nephronophthisis 4
Description	This gene encodes a protein involved in renal tubular development and function. This protein interacts with nephrocystin, and belongs to a multifunctional complex that is localized to actin- and microtubule-based structures. Mutations in this gene are associated with nephronophthisis type 4, a renal disease, and with Senior-Loken syndrome type 4, a combination of nephronophthisis and retinitis pigmentosa. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNPHP4 encodes a protein, known as nephrocystin‐4 (or nephroretinin), that plays a critical role in the pathogenesis of nephronophthisis—a cystic kidney disease that represents the most common genetic cause of chronic renal failure in children. Mutations in NPHP4 are linked not only to renal cyst formation, interstitial fibrosis, and progression to end‐stage renal disease but also to extrarenal manifestations such as retinal dystrophy seen in Senior–Løken syndrome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the cellular level, nephrocystin‐4 localizes predominantly to the primary cilia, especially at the basal bodies and centrosomes, and associates with key cytoskeletal components such as α‐ and β‐tubulin. It forms complexes with proteins involved in cell adhesion—like p130Cas and Pyk2—thereby contributing to the organization of cell–cell and cell–matrix signaling events that are essential for the proper development and maintenance of renal tubules."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its structural functions, NPHP4 is a pivotal regulator of several signaling pathways. It acts as a potent negative regulator of the Hippo pathway by directly interacting with the kinase Lats1, reducing the phosphorylation of the protooncogenic transcriptional regulators YAP and TAZ, which ultimately promotes their nuclear translocation and transcriptional activity. In addition, by interacting with proteins such as RPGRIP1 and Jade‐1, nephrocystin‐4 modulates canonical Wnt signaling—a pathway crucial for the maintenance of renal tissue architecture and the prevention of cystogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditionally, NPHP4 is essential for the regulation of ciliary membrane composition and function. It recruits motor proteins such as KIF13B to the ciliary base and facilitates the formation of specialized membrane microdomains at the transition zone. These microdomains are important for the proper activation of developmental signaling cascades such as the Sonic hedgehog pathway, underscoring the role of nephrocystin‐4 in integrating structural and signaling functions within the cilium."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nComprehensive genetic studies have revealed considerable mutational heterogeneity in NPHP4. Loss‐of-function mutations and deleterious sequence variants contribute to a spectrum of clinical phenotypes—including juvenile and adult‐onset nephronophthisis, Senior–Løken syndrome, cerebello–oculo–renal syndrome, and even reproductive anomalies such as impaired spermatogenesis—often in the context of oligogenic inheritance with other nephrocystin genes. These findings emphasize the multifaceted roles of NPHP4 in renal development, ciliary signaling, and broader tissue homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "18"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Edgar Otto, Julia Hoefele, Rainer Ruf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A gene mutated in nephronophthisis and retinitis pigmentosa encodes a novel protein, nephroretinin, conserved in evolution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/344395"}], "href": "https://doi.org/10.1086/344395"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12205563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12205563"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Géraldine Mollet, Rémi Salomon, Olivier Gribouval, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng996"}], "href": "https://doi.org/10.1038/ng996"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12244321"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12244321"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Géraldine Mollet, Flora Silbermann, Marion Delous, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddi061"}], "href": "https://doi.org/10.1093/hmg/ddi061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15661758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15661758"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Julia Hoefele, Ralf Sudbrak, Richard Reinhardt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutational analysis of the NPHP4 gene in 250 patients with nephronophthisis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.9326"}], "href": "https://doi.org/10.1002/humu.9326"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15776426"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15776426"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ronald Roepman, Stef J F Letteboer, Heleen H Arts, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of nephrocystin-4 and RPGRIP1 is disrupted by nephronophthisis or Leber congenital amaurosis-associated mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0505774102"}], "href": "https://doi.org/10.1073/pnas.0505774102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16339905"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16339905"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sandra Habbig, Malte P Bartram, Roman U Müller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201009069"}], "href": "https://doi.org/10.1083/jcb.201009069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21555462"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21555462"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lori Borgal, Sandra Habbig, Julia Hatzold, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.385658"}], "href": "https://doi.org/10.1074/jbc.M112.385658"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22654112"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22654112"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Kenneth B Schou, Johanne B Mogensen, Stine K Morthorst, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms14177"}], "href": "https://doi.org/10.1038/ncomms14177"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28134340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28134340"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Julia Hoefele, Matthias T F Wolf, John F O'Toole, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence of oligogenic inheritance in nephronophthisis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2007020243"}], "href": "https://doi.org/10.1681/ASN.2007020243"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17855640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17855640"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kirtida Mistry, James H E Ireland, Roland C K Ng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel mutations in NPHP4 in a consanguineous family with histological findings of focal segmental glomerulosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Kidney Dis (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.ajkd.2007.08.009"}], "href": "https://doi.org/10.1053/j.ajkd.2007.08.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17954299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17954299"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Tsuneo Konta, Satoshi Takasaki, Kazunobu Ichikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The novel and independent association between single-point SNP of NPHP4 gene and renal function in non-diabetic Japanese population: the Takahata study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jhg.2010.113"}], "href": "https://doi.org/10.1038/jhg.2010.113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20844548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20844548"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Vanessa M French, Ingrid M B H van de Laar, Marja W Wessels, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NPHP4 variants are associated with pleiotropic heart malformations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.112.269795"}], "href": "https://doi.org/10.1161/CIRCRESAHA.112.269795"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22550138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22550138"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "A M Alazami, M J Alshammari, M Baig, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NPHP4 mutation is linked to cerebello-oculo-renal syndrome and male infertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.12160"}], "href": "https://doi.org/10.1111/cge.12160"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23574405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23574405"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Valentin Penchev, Anelia Boueva, Kunka Kamenarova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A familial case of severe infantile nephronophthisis explained by oligogenic inheritance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Med Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejmg.2017.04.002"}], "href": "https://doi.org/10.1016/j.ejmg.2017.04.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28392475"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28392475"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Rebecca Hudson, Chirag Patel, Carmel M Hawley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adult-Diagnosed Nonsyndromic Nephronophthisis in Australian Families Caused by Biallelic NPHP4 Variants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Kidney Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.ajkd.2019.08.031"}], "href": "https://doi.org/10.1053/j.ajkd.2019.08.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31810733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31810733"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Claudia Yahalom, Oded Volovelsky, Michal Macarov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SENIOR-LØKEN SYNDROME: A Case Series and Review of the Renoretinal Phenotype and Advances of Molecular Diagnosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Retina (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/IAE.0000000000003138"}], "href": "https://doi.org/10.1097/IAE.0000000000003138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33512896"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33512896"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yoichiro Otaki, Tetsu Watanabe, Junya Sato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of Nephronophthisis 4 genetic variation with cardiorenal syndrome and cardiovascular events in Japanese general population: the Yamagata (Takahata) study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Heart Vessels (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00380-021-01953-5"}], "href": "https://doi.org/10.1007/s00380-021-01953-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34591160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34591160"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Asim Ali, Ahsanullah Unar, Zubair Muhammad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel NPHP4 homozygous missense variant identified in infertile brothers with multiple morphological abnormalities of the sperm flagella."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Assist Reprod Genet (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10815-023-02966-x"}], "href": "https://doi.org/10.1007/s10815-023-02966-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37831349"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37831349"}]}]}]}
Synonyms	SLSN4, POC10
Proteins	NPHP4_HUMAN
NCBI Gene ID	261734
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NPHP4 has 5,817 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 116 datasets.

Click the + buttons to view associations for NPHP4 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NPHP4 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by NPHP4 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NPHP4 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NPHP4 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NPHP4 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NPHP4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NPHP4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NPHP4 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NPHP4 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NPHP4 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NPHP4 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NPHP4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NPHP4 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with NPHP4 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NPHP4 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NPHP4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NPHP4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with NPHP4 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with NPHP4 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing NPHP4 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NPHP4 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NPHP4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NPHP4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NPHP4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NPHP4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NPHP4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NPHP4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NPHP4 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NPHP4 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with NPHP4 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of NPHP4 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by NPHP4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving NPHP4 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving NPHP4 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NPHP4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NPHP4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NPHP4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NPHP4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NPHP4 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NPHP4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NPHP4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.