{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA comprehensive review of the 43 abstracts"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "42"}]}, {"type": "t", "text": "reveals that none of these studies address NPY4R2. Instead, the literature provided centers on the functions of signaling mediators—most notably phospholipase C–gamma1 (PLCγ1)—in various cellular contexts such as neuronal plasticity, immune cell activation, integrin-dependent adhesion, cell motility, and apoptosis.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMany of these abstracts detail how PLCγ1 is rapidly activated—for instance via neurotrophin receptors like TrkB in response to antidepressants"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "—or how its activation orchestrates key downstream events including Ca²⁺ mobilization, MAPK activation, and cytoskeletal reorganization, processes that are essential to T cell receptor signaling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": "and to integrin-mediated adhesion and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}, {"type": "fg_f", "ref": "28"}]}, {"type": "t", "text": " Other studies focus on PLCγ1’s role in modulating apoptotic and survival pathways in diverse cell types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Collectively, the abstracts underscore the centrality of PLCγ1-dependent signal transduction cascades yet do not mention or provide data on NPY4R2.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, none of the supplied abstracts contain any reference to NPY4R2 or its function. 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