{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNRP2 plays a central role in vascular and lymphatic development by functioning as a versatile co‐receptor for members of the VEGF‐ligand family. In lymphatic endothelial cells, NRP2 directly binds VEGF‑C and VEGF‑D and associates with VEGFR‑3 to promote lymphangiogenesis, while in blood endothelial cells it acts as a coreceptor for VEGF‑A and VEGF‑C to enhance cell survival, migration, and angiogenic signaling. In addition, NRP2 modulates proangiogenic pathways downstream of other factors such as HGF and is regulated during endothelial differentiation by transcriptional mediators like GATA2/Lmo2."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in normal vascular biology, NRP2 is a key contributor to cancer progression. In tumor cells, NRP2 promotes tumor‐initiating potential, epithelial–mesenchymal transition, and metastasis by engaging in autocrine and paracrine loops that activate integrin, MAPK, and Hedgehog signaling cascades. For example, in triple‐negative breast cancer the VEGF/NRP2 axis stimulates integrin‑ and GLI1‑dependent pathways, while in colorectal, prostate, and lung cancers distinct NRP2 isoforms contribute to enhanced migration, invasion, lymphangiogenesis, and drug resistance. In addition, NRP2 has been implicated in mediating viral entry as the receptor for the cytomegalovirus pentamer complex."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its vascular and oncogenic roles, NRP2 contributes to immune cell regulation and neural development. 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"}, {"type": "b", "children": [{"type": "t", "text": "Neuropilin-2 mediates lymphangiogenesis of colorectal carcinoma via a VEGFC/VEGFR3 independent signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2014.12.046"}], "href": "https://doi.org/10.1016/j.canlet.2014.12.046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25543087"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25543087"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Samikshan Dutta, Sohini Roy, Navatha S Polavaram, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuropilin-2 Regulates Endosome Maturation and EGFR Trafficking to Support Cancer Cell Pathobiology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-15-1488"}], "href": "https://doi.org/10.1158/0008-5472.CAN-15-1488"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26560516"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26560516"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Tsun Ming Fung, Kai Yu Ng, Man Tong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuropilin-2 promotes tumourigenicity and metastasis in oesophageal squamous cell carcinoma through ERK-MAPK-ETV4-MMP-E-cadherin deregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.4728"}], "href": "https://doi.org/10.1002/path.4728"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27063000"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27063000"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Robert M Gemmill, Patrick Nasarre, Joyce Nair-Menon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The neuropilin 2 isoform NRP2b uniquely supports TGFβ-mediated progression in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.aag0528"}], "href": "https://doi.org/10.1126/scisignal.aag0528"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28096505"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28096505"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jingwen Wang, Yuhong Huang, Jun Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NRP-2 in tumor lymphangiogenesis and lymphatic metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2018.01.040"}], "href": "https://doi.org/10.1016/j.canlet.2018.01.040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29339213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29339213"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ameer L Elaimy, Santosh Guru, Cheng Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP β2-chimaerin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.aao6897"}], "href": "https://doi.org/10.1126/scisignal.aao6897"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29717062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29717062"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Nadia Martinez-Martin, Jessica Marcandalli, Christine S Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2018.06.028"}], "href": "https://doi.org/10.1016/j.cell.2018.06.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30057110"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30057110"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Suping Wu, Weihua Yue, Meixiang Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of the neuropilin-2 (NRP2) gene polymorphisms with autism in Chinese Han population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet B Neuropsychiatr Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.b.30495"}], "href": "https://doi.org/10.1002/ajmg.b.30495"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17427189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17427189"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Sabrina Curreli, Zita Arany, Rita Gerardy-Schahn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polysialylated neuropilin-2 is expressed on the surface of human dendritic cells and modulates dendritic cell-T lymphocyte interactions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M702965200"}], "href": "https://doi.org/10.1074/jbc.M702965200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17699524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17699524"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Donggoo Bae, Shaolei Lu, Cherie A Taglienti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M804203200"}], "href": "https://doi.org/10.1074/jbc.M804203200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18708346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18708346"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Jong-Dae Ji, Kyung-Hyun Park-Min, Lionel B Ivashkiv "}, {"type": "b", "children": [{"type": "t", "text": "Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humimm.2009.01.026"}], "href": "https://doi.org/10.1016/j.humimm.2009.01.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19480842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19480842"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Angela Rey-Gallardo, Cristina Delgado-Martín, Rita Gerardy-Schahn, et al. 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