{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNSG2 is a neuron‐specific endosomal protein highly expressed during perinatal brain development. The protein localizes to discrete punctae within the somatodendritic compartments of both mouse and human neurons, where many of these punctae colocalize with postsynaptic markers such as HOMER1 and surface-expressed AMPA-type glutamate receptors. This distribution suggests that NSG2 plays a role in organizing key components at excitatory synapses, ensuring proper receptor positioning and function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nNSG2 physically interacts with the GluA1 and GluA2 subunits of AMPA receptors, as demonstrated by immunoprecipitation from mouse brain tissue. Functional studies reveal that loss of NSG2 impairs synaptic transmission by reducing the frequency of miniature excitatory postsynaptic currents (mEPSCs) and altering the expression of PSD95 at postsynaptic densities, while its overexpression enhances mEPSC amplitude and increases GluA2 surface expression. These findings indicate that NSG2 is essential for normal synapse formation and/or maintenance, operating through unique mechanisms distinct from other members of the NSG protein family."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Praveen Chander, Matthew J Kennedy, Bettina Winckler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuron-Specific Gene 2 (NSG2) Encodes an AMPA Receptor Interacting Protein That Modulates Excitatory Neurotransmission."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "eNeuro (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/ENEURO.0292-18.2018"}], "href": "https://doi.org/10.1523/ENEURO.0292-18.2018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30680309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30680309"}]}]}]}