{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLong noncoding RNA NUTM2A‐AS1 has emerged as an oncogenic regulator in multiple tumor types. In gastric cancer, elevated levels of NUTM2A‐AS1 promote cell viability, invasive capacity, and resistance to chemotherapeutic agents by acting as a molecular sponge for miR-376a. This interaction deregulates downstream targets such as TET1 and HIF-1A, which in turn modulate PD-L1 expression and contribute to tumorigenesis and drug resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In hepatocellular carcinoma, NUTM2A‐AS1 facilitates tumor progression by sequestering miR-186-5p, leading to the upregulation of KLF7 expression and subsequent activation of the Wnt/β-catenin signaling pathway. This cascade enhances epithelial-mesenchymal transition (EMT) and stemness properties, thereby driving aggressive disease behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "In a parallel context of gastric cancer, NUTM2A‐AS1 contributes to resistance against the anticancer agent matrine. The lncRNA modulates oxidative stress responses—evidenced by alterations in reactive oxygen species production, glutathione content, and superoxide dismutase activity—and affects vascular endothelial growth factor A (VEGFA) expression through regulation of miR-613, together promoting a drug-resistant phenotype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "Further extending its oncogenic repertoire, in neuroblastoma NUTM2A‐AS1 is upregulated in cisplatin-resistant cells where it impairs the degradation of the immune checkpoint protein B7-H3, thus fostering immune evasion. In these cells, NUTM2A‐AS1 is transcriptionally activated by NR1D1, highlighting a novel NR1D1/NUTM2A‐AS1/B7-H3 axis that underpins both drug resistance and metastatic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ji Wang, Ziyang Yu, Jun Wang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "LncRNA NUTM2A-AS1 aggravates the progression of hepatocellular carcinoma by activating the miR-186-5p/KLF7-mediated Wnt/beta-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-022-00802-5"}], "href": "https://doi.org/10.1007/s13577-022-00802-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36242728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36242728"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Haifeng Ying, Yinchun Jin, Yuanbiao Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA NUT family member 2A-antisense RNA 1 sponges microRNA-613 to increase the resistance of gastric cancer cells to matrine through regulating oxidative stress and vascular endothelial growth factor A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.204135"}], "href": "https://doi.org/10.18632/aging.204135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35771149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35771149"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tian Xiang, Yejing Li, Gao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NR1D1-transactivated lncRNA NUTM2A-AS1 promotes chemoresistance and immune evasion in neuroblastoma via inhibiting B7-H3 degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.18360"}], "href": "https://doi.org/10.1111/jcmm.18360"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38785199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38785199"}]}]}]}