| Name | outer dynein arm docking complex subunit 2 |
| Description | The protein encoded by this gene contains ten Armadillo repeat motifs (ARMs) and one HEAT repeat, and is thought to be involved in ciliary and flagellar movement. This protein has been shown to localize to the ciliary axonemes and at the ciliary base of respiratory cells. Studies indicate that mutations in this gene cause partial outer dynein arm (ODA) defects in respiratory cilia. The cilia of cells with mutations in this gene displayed either reduced ciliary beat frequency and amplitude, or, complete immotility. Some individuals with primary ciliary dyskensia (PCD) have been shown to have mutations in this gene. PCD is characterized by chronic airway disease and left/right body asymmetry defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nODAD2 is a protein that plays a critical role in the proper assembly and function of motile cilia. It functions as part of the docking machinery that targets and anchors the preassembled outer dynein arm (ODA) complexes to the ciliary axoneme, thereby enabling the robust generation of ciliary beating. Defects in proteins with such docking functions lead to reduced ODA numbers, diminished ciliary motility, and can underlie primary ciliary dyskinesia (PCD) as well as disruptions in left–right patterning."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nStudies on ciliopathies have demonstrated that when components of the ODA docking complex are mutated—like ARMC4 in one analysis—the targeting and stable anchoring of ODAs to the axoneme are compromised. By analogy, mutations in ODAD2 are expected to similarly impair ciliary beating, leading to clinical features that include chronic respiratory defects and laterality abnormalities. This evidence underscores the pivotal role of ODAD2 in coordinating the cytoplasmic preassembly and subsequent precise delivery of ODAs to their proper axonemal location for effective ciliary function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rim Hjeij, Anna Lindstrand, Richard Francis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2013.06.009"}], "href": "https://doi.org/10.1016/j.ajhg.2013.06.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23849778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23849778"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Alexandros Onoufriadis, Amelia Shoemark, Mustafa M Munye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Combined exome and whole-genome sequencing identifies mutations in ARMC4 as a cause of primary ciliary dyskinesia with defects in the outer dynein arm."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmedgenet-2013-101938"}], "href": "https://doi.org/10.1136/jmedgenet-2013-101938"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24203976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24203976"}]}]}]}
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| NCBI Gene ID | 55130 |
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| Expression in Tissues and Cell Lines |
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ODAD2 has 1,335 functional associations with biological entities spanning 6 categories (chemical, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 23 datasets.
Click the + buttons to view associations for ODAD2 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ODAD2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of ODAD2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with ODAD2 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ClinVar Gene-Phenotype Associations 2025 | phenotypes associated with ODAD2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of ODAD2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing ODAD2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with ODAD2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| GlyGen Glycosylated Proteins | ligands (chemical) binding ODAD2 protein from the GlyGen Glycosylated Proteins dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving ODAD2 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of ODAD2 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of ODAD2 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with ODAD2 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by ODAD2 gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of ODAD2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of ODAD2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of ODAD2 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of ODAD2 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of ODAD2 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of ODAD2 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tahoe Therapeutics Tahoe 100M Perturbation Atlas | drug perturbations changing expression of ODAD2 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ODAD2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with ODAD2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving ODAD2 protein from the WikiPathways Pathways 2024 dataset. | |
