{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nODAPH, encoded by the gene originally designated as C4orf26, is a secreted, extracellular matrix acidic phosphoprotein that is specifically expressed in the enamel organ during tooth development. Its phosphorylated C-terminal domain plays a crucial role in promoting the nucleation of hydroxyapatite crystals, a fundamental step in the mineralization process that leads to the formation of mature enamel."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nLoss‐of‐function mutations in ODAPH result in recessive hypomineralized amelogenesis imperfecta, a condition characterized by enamel that is improperly mineralized and therefore structurally compromised. This finding underscores the essential function of ODAPH in regulating the initial nucleation event during amelogenesis, thereby establishing the proper framework for enamel strength and durability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "David A Parry, Steven J Brookes, Clare V Logan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in C4orf26, encoding a peptide with in vitro hydroxyapatite crystal nucleation and growth activity, cause amelogenesis imperfecta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2012.07.020"}], "href": "https://doi.org/10.1016/j.ajhg.2012.07.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22901946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22901946"}]}]}]}