{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nOLMALINC, a member of the long intervening non‐coding RNAs (lincRNAs), is implied to participate in regulatory networks by exhibiting tissue‐specific expression patterns. As lincRNAs have been shown to contribute to pervasive transcription and display high abundance in the brain—underscoring a possible role in modulating neural gene programs"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "—OLMALINC may similarly be involved in the fine‐tuning of gene expression in neural tissues.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence also indicates that non‐coding RNAs can influence cellular reprogramming events. For example, studies of osteogenic-like cell formation in the context of Randall's plaques have highlighted the role of key transcription factors, such as OCT4, in reprogramming differentiated cells towards an osteoblast phenotype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Although this work does not directly address OLMALINC, it raises the possibility that, as a lincRNA, OLMALINC might participate in broader networks that modulate cell identity and fate during pathological or differentiation processes.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while direct functional studies of OLMALINC are currently limited, its inclusion in the expanding family of lincRNAs suggests it plays a role in the regulation of tissue-specific gene expression—particularly in the brain—and may contribute indirectly to cellular reprogramming processes observed in pathological settings. Further targeted research is needed to clarify its specific molecular mechanisms and regulatory targets."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "James D Mills, Tomas Kavanagh, Woojin S Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of long intervening non-coding RNA OLMALINC in the human cortical white matter is associated with regulation of oligodendrocyte maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Brain (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13041-014-0091-9"}], "href": "https://doi.org/10.1186/s13041-014-0091-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25575711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25575711"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zewu Zhu, Fang Huang, Yingcheng Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "OLMALINC/OCT4/BMP2 axis enhances osteogenic-like phenotype of renal interstitial fibroblasts to participate in Randall's plaque formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s10020-022-00576-4"}], "href": "https://doi.org/10.1186/s10020-022-00576-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36581839"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36581839"}]}]}]}