HGNC Family | G protein-coupled receptors |
Name | opiate receptor-like 1 |
Description | The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe nociceptin/orphanin FQ receptor, encoded by the OPRL1 gene, exhibits unique structural and signaling properties that distinguish it from classical opioid receptors. High‐resolution structural studies have revealed ligand–receptor contacts and divergent pocket conformations that underlie its selective binding to nociceptin‐related peptides (e.g., PMID."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Detailed investigations in cultured cells have shown that receptor activation triggers rapid, clathrin‐mediated internalization and recycling, processes critically dependent on C-terminal phosphorylation (PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and PMID."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Complementary mapping studies and mutagenesis further delineated the ligand‐bound conformations and key cysteine residues within the transmembrane domains that contribute to binding and dimerization with other G protein‐coupled receptors, thus modulating G protein engagement and biased signaling (PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and PMID."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, studies in heterologous systems have confirmed that OPRL1 efficiently couples to inhibitory G proteins and undergoes desensitization dynamics similar to other opioid receptors (PMID."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOPRL1 plays a pivotal role in the modulation of stress, fear, addiction, and affective processes. Experimental work in animal models demonstrates that receptor activation within amygdalar circuits impairs fear memory consolidation, suggesting a protective “brake” mechanism against posttraumatic stress disorder (PMID."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Genetic and epigenetic association studies have linked OPRL1 variants and promoter methylation changes to increased vulnerability to alcohol dependence and other substance use disorders, while the downregulation of its endogenous ligand system in key limbic regions may underlie deficits in cognitive control observed in alcoholism (PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", and PMID."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In humans, neuroimaging and allelic studies further implicate this receptor in stress resilience and suicide risk, and methylation analyses support its involvement in stress‐related alcohol use (PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ", PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": ", PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ", and PMID."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond central effects, OPRL1 is expressed in peripheral tissues where it contributes to immune regulation and vascular functions. Mapping studies in human trigeminal ganglia have identified robust nociceptin immunoreactivity and OPRL1 mRNA colocalizing with neuropeptides involved in nociception (PMID."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": " In immune cells, activation of the receptor modulates chemokine production and cross‐desensitizes other chemotactic receptors, thereby influencing inflammatory responses (PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "and PMID."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": " Consistent with these findings, expression on leukocyte subsets has been linked to altered cytokine output, and cross-talk with receptors such as CXCR4 may reduce susceptibility to viral infection (PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "and PMID."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": " In addition, expression in endothelial cells and skin has been associated with MAP kinase activation and modulation of neuropathic pain symptoms, underscoring the receptor’s role in vascular homeostasis (PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": "and PMID"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": ", while altered plasma levels of nociceptin have been observed in acute cardiovascular disease (PMID."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional research highlights the involvement of OPRL1 in neural repair and reproductive functions. For instance, interactions with neurite growth regulators can modulate axonal glycosylation and surface expression, thereby influencing neural regeneration following traumatic injury (PMID."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "26"}]}, {"type": "t", "text": " Genetic variants of OPRL1 have also been implicated in individual differences in vulnerability to opiate addiction (PMID."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "27"}]}, {"type": "t", "text": " Moreover, within hypothalamic circuits, OPRL1 modulates reproductive behavior via regulation of β-endorphin neuronal activity, contributing to ovarian hormone feedback loops (PMID."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "28"}]}, {"type": "t", "text": " Finally, cross-talk with glutamatergic systems, as demonstrated by kainate-induced downregulation of receptor mRNA, further attests to the complex interplay of excitatory and inhibitory signals mediated by OPRL1 (PMID."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Aaron A Thompson, Wei Liu, Eugene Chun, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Serine 363 is required for nociceptin/orphanin FQ opioid receptor (NOPR) desensitization, internalization, and arrestin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.405696"}], "href": "https://doi.org/10.1074/jbc.M112.405696"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23086955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23086955"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "S Spampinato, R Di Toro, M Alessandri, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Specific affinity-labeling of the nociceptin ORL1 receptor using a thiol-activated Cys(Npys)-containing peptide ligand."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biopolymers (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/bip.22792"}], "href": "https://doi.org/10.1002/bip.22792"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27271345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27271345"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jing Chen, Zhengwen Wang, Rumin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heterodimerization of apelin and opioid receptor-like 1 receptors mediates apelin-13-induced G protein biased signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2023.121892"}], "href": "https://doi.org/10.1016/j.lfs.2023.121892"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37364634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37364634"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Prudence H Tso, Yung H Wong "}, {"type": "b", "children": [{"type": "t", "text": "Opioid receptor-like (ORL1) receptor utilizes both G(oA) and G(oB) for signal transduction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Pept Lett (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/092986606776819547"}], "href": "https://doi.org/10.2174/092986606776819547"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16800795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16800795"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Raül Andero, Shaun P Brothers, Tanja Jovanovic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Transl Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scitranslmed.3005656"}], "href": "https://doi.org/10.1126/scitranslmed.3005656"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23740899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23740899"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Alexander Kuzmin, Igor Bazov, Donna Sheedy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of pronociceptin and its receptor is downregulated in the brain of human alcoholics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.brainres.2009.05.067"}], "href": "https://doi.org/10.1016/j.brainres.2009.05.067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19501074"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19501074"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jia Huang, Brandon Young, Mathew T Pletcher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between the nociceptin receptor gene (OPRL1) single nucleotide polymorphisms and alcohol dependence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Addict Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1369-1600.2007.00089.x"}], "href": "https://doi.org/10.1111/j.1369-1600.2007.00089.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18269382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18269382"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xiaoling Xuei, Leah Flury-Wetherill, Laura Almasy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association analysis of genes encoding the nociceptin receptor (OPRL1) and its endogenous ligand (PNOC) with alcohol or illicit drug dependence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Addict Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1369-1600.2007.00082.x"}], "href": "https://doi.org/10.1111/j.1369-1600.2007.00082.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17910740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17910740"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Rajesh Narendran, Savannah Tollefson, Kelli Fasenmyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased Nociceptin Receptors Are Related to Resilience and Recovery in College Women Who Have Experienced Sexual Violence: Therapeutic Implications for Posttraumatic Stress Disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2019.02.017"}], "href": "https://doi.org/10.1016/j.biopsych.2019.02.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30954231"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30954231"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Pierre-Eric Lutz, Yi Zhou, Aurélie Labbe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression of nociceptin/orphanin FQ in the dorsal anterior cingulate cortex of suicides."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Neuropsychopharmacol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.euroneuro.2015.08.015"}], "href": "https://doi.org/10.1016/j.euroneuro.2015.08.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26349406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26349406"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Barbara Ruggeri, Christine Macare, Serena Stopponi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Child Psychol Psychiatry (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcpp.12843"}], "href": "https://doi.org/10.1111/jcpp.12843"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29197086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29197086"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Allison Jane Fulford "}, {"type": "b", "children": [{"type": "t", "text": "Endogenous nociceptin system involvement in stress responses and anxiety behavior."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Vitam Horm (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/bs.vh.2014.12.012"}], "href": "https://doi.org/10.1016/bs.vh.2014.12.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25677776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25677776"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Xinmin Simon Xie "}, {"type": "b", "children": [{"type": "t", "text": "The neuronal circuit between nociceptin/orphanin FQ and hypocretins/orexins coordinately modulates stress-induced analgesia and anxiety-related behavior."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Vitam Horm (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/bs.vh.2014.11.004"}], "href": "https://doi.org/10.1016/bs.vh.2014.11.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25677777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25677777"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Mingyan Hou, Rolf Uddman, Janos Tajti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nociceptin immunoreactivity and receptor mRNA in the human trigeminal ganglion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-8993(02)03927-6"}], "href": "https://doi.org/10.1016/s0006-8993(02"}, {"type": "t", "text": "03927-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12576178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12576178"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Elaine C Gavioli, Iris Ucella de Medeiros, Marta C Monteiro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nociceptin/orphanin FQ-NOP receptor system in inflammatory and immune-mediated diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Vitam Horm (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/bs.vh.2014.11.003"}], "href": "https://doi.org/10.1016/bs.vh.2014.11.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25677775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25677775"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "David E Kaminsky, Thomas J Rogers "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of CCL2/MCP-1 and CCL5/RANTES expression by nociceptin in human monocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroimmune Pharmacol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11481-007-9086-y"}], "href": "https://doi.org/10.1007/s11481-007-9086-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18247127"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18247127"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "C Krüger, L Köthe, A Struppert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Expression und function of the ORL-1 receptor on human leukocytes]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Schmerz (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00482-006-0488-1"}], "href": "https://doi.org/10.1007/s00482-006-0488-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16807742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16807742"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "David E Kaminsky, Thomas J Rogers "}, {"type": "b", "children": [{"type": "t", "text": "Nociceptin/orphanin FQ receptor-driven heterologous desensitization of the major HIV-1 co-receptor CXCR4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuroimmune Pharmacol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11481-011-9285-4"}], "href": "https://doi.org/10.1007/s11481-011-9285-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21656184"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21656184"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Filippo Granata, Rossella Luisa Potenza, Anna Fiori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Pharmacol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejphar.2003.09.049"}], "href": "https://doi.org/10.1016/j.ejphar.2003.09.049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14660000"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14660000"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Baohan Pan, Wolfgang Schröder, Ruth Jostock, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nociceptin/orphanin FQ opioid peptide-receptor expression in pachyonychia congenita."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Peripher Nerv Syst (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jns.12288"}], "href": "https://doi.org/10.1111/jns.12288"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30255608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30255608"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Cs Csobay-Novák, P Sótonyi, M Krepuska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased plasma nociceptin/orphanin FQ levels after acute coronary syndromes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Physiol Hung (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1556/APhysiol.99.2012.2.2"}], "href": "https://doi.org/10.1556/APhysiol.99.2012.2.2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22849833"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22849833"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Yuichi Sekine, Chad S Siegel, Tomoko Sekine-Konno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.aao4180"}], "href": "https://doi.org/10.1126/scisignal.aao4180"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29615517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29615517"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Judith A Briant, David A Nielsen, Dmitri Proudnikov, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Kainic acid down-regulates NOP receptor density and gene expression in human neuroblastoma SH-SY5Y cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12031-008-9038-x"}], "href": "https://doi.org/10.1007/s12031-008-9038-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18286384"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18286384"}]}]}]}
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Synonyms | KOR-3, NOCIR, OOR, ORL1, NOPr |
Proteins | OPRX_HUMAN |
NCBI Gene ID | 4987 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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OPRL1 has 4,376 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 104 datasets.
Click the + buttons to view associations for OPRL1 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
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Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of OPRL1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of OPRL1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of OPRL1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of OPRL1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of OPRL1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of OPRL1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OPRL1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OPRL1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of OPRL1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of OPRL1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with OPRL1 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OPRL1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of OPRL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of OPRL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of OPRL1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing OPRL1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with OPRL1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of OPRL1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with OPRL1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with OPRL1 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with OPRL1 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by OPRL1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with OPRL1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with OPRL1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with OPRL1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
DrugBank Drug Targets | interacting drugs for OPRL1 protein from the curated DrugBank Drug Targets dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OPRL1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OPRL1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of OPRL1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing OPRL1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with OPRL1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with OPRL1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of OPRL1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with OPRL1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing OPRL1 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of OPRL1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of OPRL1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of OPRL1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of OPRL1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of OPRL1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of OPRL1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GO Biological Process Annotations 2015 | biological processes involving OPRL1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving OPRL1 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving OPRL1 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing OPRL1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing OPRL1 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing OPRL1 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by OPRL1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by OPRL1 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by OPRL1 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx eQTL 2025 | SNPs regulating expression of OPRL1 gene from the GTEx eQTL 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of OPRL1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of OPRL1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of OPRL1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
Guide to Pharmacology Chemical Ligands of Receptors | ligands (chemical) binding OPRL1 receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. | |
Guide to Pharmacology Protein Ligands of Receptors | ligands (protein) binding OPRL1 receptor from the curated Guide to Pharmacology Protein Ligands of Receptors dataset. | |
GWASdb SNP-Disease Associations | diseases associated with OPRL1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with OPRL1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of OPRL1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of OPRL1 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of OPRL1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of OPRL1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for OPRL1 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with OPRL1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by OPRL1 gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for OPRL1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of OPRL1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEGG Pathways | pathways involving OPRL1 protein from the KEGG Pathways dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of OPRL1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of OPRL1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with OPRL1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of OPRL1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of OPRL1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain OPRL1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by OPRL1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of OPRL1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by OPRL1 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
MSigDB Cancer Gene Co-expression Modules | co-expressed genes for OPRL1 from the MSigDB Cancer Gene Co-expression Modules dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of OPRL1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of OPRL1 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
NURSA Protein Complexes | protein complexs containing OPRL1 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
PANTHER Pathways | pathways involving OPRL1 protein from the PANTHER Pathways dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for OPRL1 from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of OPRL1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of OPRL1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving OPRL1 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving OPRL1 protein from the Wikipathways PFOCR 2024 dataset. | |
Phosphosite Textmining Biological Term Annotations | biological terms co-occuring with OPRL1 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset. | |
PhosphoSitePlus Substrates of Kinases | kinases that phosphorylate OPRL1 protein from the curated PhosphoSitePlus Substrates of Kinases dataset. | |
Reactome Pathways 2014 | pathways involving OPRL1 protein from the Reactome Pathways dataset. | |
Reactome Pathways 2024 | pathways involving OPRL1 protein from the Reactome Pathways 2024 dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of OPRL1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OPRL1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OPRL1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of OPRL1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of OPRL1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of OPRL1 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of OPRL1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of OPRL1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of OPRL1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of OPRL1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with OPRL1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
WikiPathways Pathways 2014 | pathways involving OPRL1 protein from the Wikipathways Pathways 2014 dataset. | |
WikiPathways Pathways 2024 | pathways involving OPRL1 protein from the WikiPathways Pathways 2024 dataset. | |