| HGNC Family | G protein-coupled receptors |
| Name | olfactory receptor, family 10, subfamily G, member 3 |
| Description | Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA careful review of the provided abstracts reveals a wealth of information regarding the roles of SH2/SH3‐domain–containing adaptor proteins—most notably the Nck family—in mediating phosphotyrosine‐dependent signaling events that regulate actin cytoskeletal dynamics, cell migration, polarity, and other key cellular processes (e.g., in podocyte morphogenesis, neuronal guidance, immune responses, and translational control). However, none of these studies address—or even mention—the gene OR10G3. In this body of literature, while multiple signaling nodes are dissected in detail, there is no evidence linking OR10G3 to any function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast to the expansive insights provided on adaptor-mediated regulation of cellular architecture and signal transduction, the current literature does not implicate OR10G3—a gene typically classified within the olfactory receptor family—in these processes. Collectively, the studies emphasize that adaptor proteins such as Nck are central to coupling receptor activation (via tyrosine phosphorylation) to actin polymerization and downstream cellular events in diverse biological systems. Without any mention or functional analysis of OR10G3 in these contexts, no functional role for OR10G3 can be deduced from the available data, underscoring the need for future research to explore whether OR10G3 may have any related or distinct cellular functions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sem Kebache, Dongmei Zuo, Eric Chevet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Modulation of protein translation by Nck-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.082483399"}], "href": "https://doi.org/10.1073/pnas.082483399"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11959995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11959995"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Friedhelm Bladt, Elke Aippersbach, Sigal Gelkop, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.13.4586-4597.2003"}], "href": "https://doi.org/10.1128/MCB.23.13.4586-4597.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12808099"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12808099"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kenneth G Campellone, Susannah Rankin, Tony Pawson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200306032"}], "href": "https://doi.org/10.1083/jcb.200306032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14757753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14757753"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Andrea L Szymczak, Creg J Workman, Diana Gil, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The CD3epsilon proline-rich sequence, and its interaction with Nck, is not required for T cell development and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.175.1.270"}], "href": "https://doi.org/10.4049/jimmunol.175.1.270"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15972658"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15972658"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nina Jones, Ivan M Blasutig, Vera Eremina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature04662"}], "href": "https://doi.org/10.1038/nature04662"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16525419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16525419"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rakesh Verma, Iulia Kovari, Abdul Soofi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI27414"}], "href": "https://doi.org/10.1172/JCI27414"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16543952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16543952"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "G M Rivera, S Antoku, S Gelkop, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0603786103"}], "href": "https://doi.org/10.1073/pnas.0603786103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16769879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16769879"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Mathieu Latreille, Louise Larose "}, {"type": "b", "children": [{"type": "t", "text": "Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M513556200"}], "href": "https://doi.org/10.1074/jbc.M513556200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16835242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16835242"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yukako Yokota, Colleen Ring, Rockie Chong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nap1-regulated neuronal cytoskeletal dynamics is essential for the final differentiation of neurons in cerebral cortex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2007.04.016"}], "href": "https://doi.org/10.1016/j.neuron.2007.04.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17481396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17481396"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "James P Fawcett, John Georgiou, Julie Ruston, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nck adaptor proteins control the organization of neuronal circuits important for walking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0710316105"}], "href": "https://doi.org/10.1073/pnas.0710316105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18093944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18093944"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Shengxi Guan, Jianhua Fan, Arum Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Non-compensating roles between Nckalpha and Nckbeta in PDGF-BB signaling to promote human dermal fibroblast migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2008.457"}], "href": "https://doi.org/10.1038/jid.2008.457"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19242519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19242519"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Nina Jones, Laura A New, Megan A Fortino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nck proteins maintain the adult glomerular filtration barrier."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2009010056"}], "href": "https://doi.org/10.1681/ASN.2009010056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19443634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19443634"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Tomoko Fukumi-Tominaga, Yoshiko Mori, Atsuko Matsuura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DIP/WISH-deficient mice reveal Dia- and N-WASP-interacting protein as a regulator of cytoskeletal dynamics in embryonic fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2443.2009.01345.x"}], "href": "https://doi.org/10.1111/j.1365-2443.2009.01345.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19778379"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19778379"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Mathieu Latreille, Marie-Kristine Laberge, Geneviève Bourret, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion of Nck1 attenuates hepatic ER stress signaling and improves glucose tolerance and insulin signaling in liver of obese mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Endocrinol Metab (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpendo.00088.2010"}], "href": "https://doi.org/10.1152/ajpendo.00088.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20587749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20587749"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Edwige Roy, Dieudonnée Togbe, Amy Holdorf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fine tuning of the threshold of T cell selection by the Nck adapters."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1000008"}], "href": "https://doi.org/10.4049/jimmunol.1000008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21078909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21078909"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Anna E Dart, Sara K Donnelly, David W Holden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nck and Cdc42 co-operate to recruit N-WASP to promote FcγR-mediated phagocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.106583"}], "href": "https://doi.org/10.1242/jcs.106583"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22454526"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22454526"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Sara K Donnelly, Ina Weisswange, Markus Zettl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WIP provides an essential link between Nck and N-WASP during Arp2/3-dependent actin polymerization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2013.04.051"}], "href": "https://doi.org/10.1016/j.cub.2013.04.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23707428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23707428"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Aldo Borroto, Irene Arellano, Raquel Blanco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Relevance of Nck-CD3 epsilon interaction for T cell activation in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1203414"}], "href": "https://doi.org/10.4049/jimmunol.1203414"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24470497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24470497"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jie Chen, Igor L Leskov, Arif Yurdagul, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recruitment of the adaptor protein Nck to PECAM-1 couples oxidative stress to canonical NF-κB signaling and inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2005648"}], "href": "https://doi.org/10.1126/scisignal.2005648"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25714462"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25714462"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ciaran Lane, Jiansong Qi, James P Fawcett "}, {"type": "b", "children": [{"type": "t", "text": "NCK is critical for the development of deleted in colorectal cancer (DCC) sensitive spinal circuits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jnc.13137"}], "href": "https://doi.org/10.1111/jnc.13137"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25913325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25913325"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Lama Yamani, Bing Li, Louise Larose "}, {"type": "b", "children": [{"type": "t", "text": "Nck1 deficiency improves pancreatic β cell survival to diabetes-relevant stresses by modulating PERK activation and signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2015.09.016"}], "href": "https://doi.org/10.1016/j.cellsig.2015.09.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26434994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26434994"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Smriti Aryal A C, Kentaro Miyai, Yayoi Izu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nck influences preosteoblastic/osteoblastic migration and bone mass."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1518253112"}], "href": "https://doi.org/10.1073/pnas.1518253112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26621720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26621720"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Alexandre Dubrac, Gael Genet, Roxana Ola, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.115.017537"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.115.017537"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26659946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26659946"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Mabruka Alfaidi, Christina H Acosta, Dongdong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective role of Nck1 in atherogenic inflammation and plaque formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI135552"}], "href": "https://doi.org/10.1172/JCI135552"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32427580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32427580"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Samantha D Pauls, Sen Hou, Aaron J Marshall "}, {"type": "b", "children": [{"type": "t", "text": "SHIP interacts with adaptor protein Nck and restricts actin turnover in B cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.04.101"}], "href": "https://doi.org/10.1016/j.bbrc.2020.04.101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32446368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32446368"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Mabruka Alfaidi, Umesh Bhattarai, A Wayne Orr "}, {"type": "b", "children": [{"type": "t", "text": "Nck1, But Not Nck2, Mediates Disturbed Flow-Induced p21-Activated Kinase Activation and Endothelial Permeability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Heart Assoc (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/JAHA.120.016099"}], "href": "https://doi.org/10.1161/JAHA.120.016099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32468886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32468886"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Antonios M Diab, Michael Wigerius, Dylan P Quinn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NCK1 Modulates Neuronal Actin Dynamics and Promotes Dendritic Spine, Synapse, and Memory Formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0495-21.2022"}], "href": "https://doi.org/10.1523/JNEUROSCI.0495-21.2022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36535770"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36535770"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Adam P Golding, Benjamin Ferrier, Laura A New, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mammary Gland Biol Neoplasia (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10911-023-09541-1"}], "href": "https://doi.org/10.1007/s10911-023-09541-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37479911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37479911"}]}]}]}
|
| Synonyms | OR14-40 |
| Proteins | O10G3_HUMAN |
| NCBI Gene ID | 26533 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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OR10G3 has 1,359 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 59 datasets.
Click the + buttons to view associations for OR10G3 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of OR10G3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of OR10G3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of OR10G3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR10G3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR10G3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR10G3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR10G3 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of OR10G3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of OR10G3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of OR10G3 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing OR10G3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with OR10G3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR10G3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with OR10G3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by OR10G3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with OR10G3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR10G3 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR10G3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of OR10G3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing OR10G3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of OR10G3 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of OR10G3 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of OR10G3 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of OR10G3 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving OR10G3 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving OR10G3 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving OR10G3 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing OR10G3 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by OR10G3 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by OR10G3 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by OR10G3 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of OR10G3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of OR10G3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with OR10G3 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with OR10G3 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of OR10G3 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of OR10G3 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for OR10G3 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of OR10G3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of OR10G3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of OR10G3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving OR10G3 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR10G3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of OR10G3 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain OR10G3 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of OR10G3 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for OR10G3 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving OR10G3 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving OR10G3 protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2014 | pathways involving OR10G3 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving OR10G3 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR10G3 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of OR10G3 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of OR10G3 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of OR10G3 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of OR10G3 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of OR10G3 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of OR10G3 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with OR10G3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
