| HGNC Family | G protein-coupled receptors |
| Name | olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene) |
| Description | Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA comprehensive review of the provided literature reveals that none of these studies directly describe the function of OR12D2. Instead, the abstracts predominantly focus on the cardiac sodium channel (primarily encoded by SCN5A) and its regulation, subcellular localization, and roles in depolarization, impulse propagation, and arrhythmogenesis. These works detail how mutations, alternative splicing, and regulatory interactions of sodium channel subunits and associated proteins critically influence cardiac conduction and predispose to diverse arrhythmic phenotypes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe manuscripts further explore mechanistic insights into how alterations in sodium channel gene expression—arising from genetic mutations, splicing variants, or abnormal intracellular signaling (including pathways involving CaMKII, FoxO1, and Wnt/β‐catenin)—affect the properties of the NaV1.5 channel. Such modifications alter conduction velocity, impulse propagation, and susceptibility to arrhythmias in both experimental models and human disease. In addition, these studies illustrate the significance of protein–protein interactions and subcellular targeting (e.g., to intercalated discs) in sustaining robust cardiac excitability."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "40"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, while the studies provide a rich understanding of the molecular underpinnings of cardiac excitability and conduction remodeling, they do not include any experimental data or discussion regarding OR12D2. With OR12D2 absent from these publications, any functional attributes of this gene remain undefined within this particular body of work. Thus, the current evidence underscores the importance of sodium channel–associated proteins in cardiac electrophysiology while leaving the role of OR12D2 to be elucidated in future investigations."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "41", "end_ref": "44"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "G Alex Papadatos, Polly M R Wallerstein, Catherine E G Head, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.082121299"}], "href": "https://doi.org/10.1073/pnas.082121299"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11972032"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11972032"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ling Wu, Kazutoshi Nishiyama, Joe G Hollyfield, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Localization of Nav1.5 sodium channel protein in the mouse brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroreport (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/00001756-200212200-00033"}], "href": "https://doi.org/10.1097/00001756-200212200-00033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12499865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12499865"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "M Tateyama, J Kurokawa, C Terrenoire, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stimulation of protein kinase C inhibits bursting in disease-linked mutant human cardiac sodium channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.CIR.0000070936.65183.97"}], "href": "https://doi.org/10.1161/01.CIR.0000070936.65183.97"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12796143"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12796143"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Niall C H Kerr, Fiona E Holmes, David Wynick "}, {"type": "b", "children": [{"type": "t", "text": "Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M401281200"}], "href": "https://doi.org/10.1074/jbc.M401281200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15047701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15047701"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jyoti D Malhotra, Veena Thyagarajan, Chunling Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M407243200"}], "href": "https://doi.org/10.1074/jbc.M407243200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15272007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15272007"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Robert Moore, Delphine Champeval, Laurence Denat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of cadherins 7 and 20 in mouse embryogenesis and melanocyte transformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1207675"}], "href": "https://doi.org/10.1038/sj.onc.1207675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15273735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15273735"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lijuan L Shang, Samuel C Dudley "}, {"type": "b", "children": [{"type": "t", "text": "Tandem promoters and developmentally regulated 5'- and 3'-mRNA untranslated regions of the mouse Scn5a cardiac sodium channel."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M409977200"}], "href": "https://doi.org/10.1074/jbc.M409977200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15485820"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15485820"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Anne Royer, Toon A B van Veen, Sabrina Le Bouter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse model of SCN5A-linked hereditary Lenègre's disease: age-related conduction slowing and myocardial fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.CIR.0000160853.19867.61"}], "href": "https://doi.org/10.1161/01.CIR.0000160853.19867.61"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15809371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15809371"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ming Lei, Catharine Goddard, Jie Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2005.083188"}], "href": "https://doi.org/10.1113/jphysiol.2005.083188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15932895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15932895"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Toon A B van Veen, Mera Stein, Anne Royer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.105.539072"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.105.539072"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16172272"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16172272"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Catherine E Head, Richard Balasubramaniam, Glyn Thomas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Paced electrogram fractionation analysis of arrhythmogenic tendency in DeltaKPQ Scn5a mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cardiovasc Electrophysiol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1540-8167.2005.00200.x"}], "href": "https://doi.org/10.1111/j.1540-8167.2005.00200.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16403066"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16403066"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Glyn Thomas, Matthew J Killeen, Iman S Gurung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanisms of ventricular arrhythmogenesis in mice following targeted disruption of KCNE1 modelling long QT syndrome 5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2006.118133"}], "href": "https://doi.org/10.1113/jphysiol.2006.118133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17095567"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17095567"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sandro L Yong, Ying Ni, Teng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the cardiac sodium channel SCN5A mutation, N1325S, in single murine ventricular myocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2006.11.019"}], "href": "https://doi.org/10.1016/j.bbrc.2006.11.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17118339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17118339"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Teng Zhang, Sandro L Yong, Xiao-Li Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cardiac-specific overexpression of SCN5A gene leads to shorter P wave duration and PR interval in transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2007.01.170"}], "href": "https://doi.org/10.1016/j.bbrc.2007.01.170"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17300750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17300750"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Lijuan L Shang, Arnold E Pfahnl, Shamarendra Sanyal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human heart failure is associated with abnormal C-terminal splicing variants in the cardiac sodium channel."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.107.152918"}], "href": "https://doi.org/10.1161/CIRCRESAHA.107.152918"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17901361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17901361"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "G Thomas, M J Killeen, A A Grace, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pharmacological separation of early afterdepolarizations from arrhythmogenic substrate in DeltaKPQ Scn5a murine hearts modelling human long QT 3 syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Physiol (Oxf) (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1748-1716.2007.01770.x"}], "href": "https://doi.org/10.1111/j.1748-1716.2007.01770.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17973950"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17973950"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ling Wu, Sandro L Yong, Chun Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav 1.5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M709721200"}], "href": "https://doi.org/10.1074/jbc.M709721200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18184654"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18184654"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "C A Remme, A O Verkerk, W M H Hoogaars, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Basic Res Cardiol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00395-009-0012-8"}], "href": "https://doi.org/10.1007/s00395-009-0012-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19255801"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19255801"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Mèra Stein, Toon A B van Veen, Carol Ann Remme, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Combined reduction of intercellular coupling and membrane excitability differentially affects transverse and longitudinal cardiac conduction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvp124"}], "href": "https://doi.org/10.1093/cvr/cvp124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19389723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19389723"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Man Liu, Shamarendra Sanyal, Ge Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cardiac Na+ current regulation by pyridine nucleotides."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.109.197277"}], "href": "https://doi.org/10.1161/CIRCRESAHA.109.197277"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19745168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19745168"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Anne-Laure Leoni, Bruno Gavillet, Jean-Sébastien Rougier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0009298"}], "href": "https://doi.org/10.1371/journal.pone.0009298"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20174578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20174578"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Maxime Albesa, Jakob Ogrodnik, Jean-Sébastien Rougier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of the cardiac sodium channel Nav1.5 by utrophin in dystrophin-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvq326"}], "href": "https://doi.org/10.1093/cvr/cvq326"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20952415"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20952415"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Kamalan Jeevaratnam, Sui Poh Tee, Yanmin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Delayed conduction and its implications in murine Scn5a(+/-) hearts: independent and interacting effects of genotype, age, and sex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pflugers Arch (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00424-010-0906-1"}], "href": "https://doi.org/10.1007/s00424-010-0906-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21127902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21127902"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Séverine Petitprez, Anne-Flore Zmoos, Jakob Ogrodnik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.110.228312"}], "href": "https://doi.org/10.1161/CIRCRESAHA.110.228312"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21164104"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21164104"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Lina Yao, Peidong Fan, Zhan Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00125.2011"}], "href": "https://doi.org/10.1152/ajpcell.00125.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21677263"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21677263"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Weike Mao, Tao You, Bo Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reactive oxygen species suppress cardiac NaV1.5 expression through Foxo1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0032738"}], "href": "https://doi.org/10.1371/journal.pone.0032738"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22400069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22400069"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "John S Lowe, Dina Myers Stroud, Tao Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvs160"}], "href": "https://doi.org/10.1093/cvr/cvs160"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22562703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22562703"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Richard P Davis, Simona Casini, Cathelijne W van den Berg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.111.066092"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.111.066092"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22647976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22647976"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Malou van den Boogaard, L Y Elaine Wong, Federico Tessadori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI62613"}], "href": "https://doi.org/10.1172/JCI62613"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22706305"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22706305"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "David E Arnolds, Fang Liu, John P Fahrenbach, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TBX5 drives Scn5a expression to regulate cardiac conduction system function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI62617"}], "href": "https://doi.org/10.1172/JCI62617"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22728936"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22728936"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Man Liu, Lianzhi Gu, Matthew S Sulkin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial dysfunction causing cardiac sodium channel downregulation in cardiomyopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yjmcc.2012.10.011"}], "href": "https://doi.org/10.1016/j.yjmcc.2012.10.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23123323"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23123323"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Elizabeth A Schroder, Mellani Lefta, Xiping Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00383.2012"}], "href": "https://doi.org/10.1152/ajpcell.00383.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23364267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23364267"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Susmita Chakrabarti, Xiaofen Wu, Zhaogang Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MOG1 rescues defective trafficking of Na(v)1.5 mutations in Brugada syndrome and sick sinus syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Arrhythm Electrophysiol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCEP.111.000206"}], "href": "https://doi.org/10.1161/CIRCEP.111.000206"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23420830"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23420830"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "James H King, Chandu Wickramarachchi, Krystine Kua, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of Nav1.5 expression and function in murine atria containing the RyR2-P2328S gain-of-function mutation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvt141"}], "href": "https://doi.org/10.1093/cvr/cvt141"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23723061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23723061"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Hirokazu Yagi, Naoki Nakagawa, Takuya Saito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycan."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep03288"}], "href": "https://doi.org/10.1038/srep03288"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24256719"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24256719"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Malou van den Boogaard, Scott Smemo, Ozanna Burnicka-Turek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A common genetic variant within SCN10A modulates cardiac SCN5A expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI73140"}], "href": "https://doi.org/10.1172/JCI73140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24642470"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24642470"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Diana Shy, Ludovic Gillet, Jakob Ogrodnik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.113.007852"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.113.007852"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24895455"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24895455"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Benzhi Cai, Ning Wang, Weike Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion of FoxO1 leads to shortening of QRS by increasing Na(+) channel activity through enhanced expression of both cardiac NaV1.5 and β3 subunit."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yjmcc.2014.06.006"}], "href": "https://doi.org/10.1016/j.yjmcc.2014.06.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24956219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24956219"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Esperanza Agullo-Pascual, Xianming Lin, Alejandra Leo-Macias, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvu195"}], "href": "https://doi.org/10.1093/cvr/cvu195"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25139742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25139742"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Patric Glynn, Hassan Musa, Xiangqiong Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCULATIONAHA.114.015218"}], "href": "https://doi.org/10.1161/CIRCULATIONAHA.114.015218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26187182"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26187182"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Ning Wang, Rong Huo, Benzhi Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of Wnt/β-catenin signaling by hydrogen peroxide transcriptionally inhibits NaV1.5 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2016.04.003"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2016.04.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27068063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27068063"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Paul D Pang, Katherina M Alsina, Shuyi Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CRISPR -Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Heart Assoc (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/JAHA.118.010393"}], "href": "https://doi.org/10.1161/JAHA.118.010393"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30371314"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30371314"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "Mona El Refaey, Hassan Musa, Nathaniel P Murphy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein Phosphatase 2A Regulates Cardiac Na"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " Channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.118.314350"}], "href": "https://doi.org/10.1161/CIRCRESAHA.118.314350"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30602331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30602331"}]}, {"type": "r", "ref": 44, "children": [{"type": "t", "text": "Louisa Mezache, Heather L Struckman, Amara Greer-Short, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vascular endothelial growth factor promotes atrial arrhythmias by inducing acute intercalated disk remodeling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-77562-5"}], "href": "https://doi.org/10.1038/s41598-020-77562-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33235263"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33235263"}]}]}]}
|
| Synonyms | DJ994E9.8, HS6M1-20 |
| Proteins | O12D2_HUMAN |
| NCBI Gene ID | 26529 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
OR12D2 has 1,657 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 67 datasets.
Click the + buttons to view associations for OR12D2 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of OR12D2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of OR12D2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of OR12D2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR12D2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR12D2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of OR12D2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR12D2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of OR12D2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR12D2 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of OR12D2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of OR12D2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of OR12D2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of OR12D2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing OR12D2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing OR12D2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with OR12D2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR12D2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with OR12D2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with OR12D2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with OR12D2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR12D2 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR12D2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of OR12D2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing OR12D2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with OR12D2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with OR12D2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of OR12D2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing OR12D2 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of OR12D2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of OR12D2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of OR12D2 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of OR12D2 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of OR12D2 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving OR12D2 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving OR12D2 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving OR12D2 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing OR12D2 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by OR12D2 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by OR12D2 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by OR12D2 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of OR12D2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of OR12D2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with OR12D2 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with OR12D2 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of OR12D2 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPM Cell Type and Tissue Protein Expression Profiles | cell types and tissues with high or low expression of OR12D2 protein relative to other cell types and tissues from the HPM Cell Type and Tissue Protein Expression Profiles dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with OR12D2 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for OR12D2 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of OR12D2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of OR12D2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving OR12D2 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR12D2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of OR12D2 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of OR12D2 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain OR12D2 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of OR12D2 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of OR12D2 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| Reactome Pathways 2014 | pathways involving OR12D2 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving OR12D2 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR12D2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of OR12D2 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of OR12D2 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of OR12D2 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of OR12D2 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of OR12D2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of OR12D2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with OR12D2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
