| HGNC Family | G protein-coupled receptors |
| Name | olfactory receptor, family 2, subfamily G, member 3 |
| Description | Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMuscle‐restricted coiled‐coil protein (MURC), also known as Cavin‐4, is a critical component of the multiprotein cavin complex that associates with caveolae—plasma membrane invaginations fundamental to cell signaling and membrane organization. In striated muscle, this complex assembles in the cytosol and is recruited by cavin‐1 to caveolae, with tissue‐specific expression suggesting distinct functions across muscle types. In cardiomyocytes and skeletal muscle, MURC not only contributes structurally to caveolar domains but also likely participates in the organization of signaling platforms that modulate cardiac as well as muscular physiology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nMuscle development and remodeling are among the key roles of MURC. In skeletal myogenesis, MURC expression overlaps with myogenin induction and is accompanied by ERK pathway activation, thereby promoting differentiation of myoblasts into mature myofibers. In the heart, overexpression of MURC enhances β₁-adrenergic receptor signaling through efficient recruitment of ERK1/2 within caveolae, which can lead to cardiomyocyte hypertrophy and even conduction disturbances. In addition, MURC interacts with proteins such as Bin1 to regulate T-tubule maturation, ensuring proper organization of the excitation–contraction machinery."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": "\n \nBeyond its roles in muscle cells, MURC influences vascular and cardiac injury responses. In pulmonary arterial smooth muscle and vascular smooth muscle cells, MURC modulates Rho/ROCK signaling, thereby affecting cellular proliferation and migration that are central to pulmonary hypertension and abdominal aortic aneurysm progression. Similarly, in the context of cardiac ischemia/reperfusion injury, MURC appears to promote reactive oxygen species-induced cell death while restraining antiapoptotic STAT3 signaling—its deletion leading to reduced infarct size and preservation of contractile function. These findings underscore MURC’s versatile role in both physiological muscle differentiation and pathological remodeling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Takehiro Ogata, Tomomi Ueyama, Koji Isodono, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.02186-07"}], "href": "https://doi.org/10.1128/MCB.02186-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18332105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18332105"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Michele Bastiani, Libin Liu, Michelle M Hill, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200903053"}], "href": "https://doi.org/10.1083/jcb.200903053"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19546242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19546242"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Masashi Tagawa, Tomomi Ueyama, Takehiro Ogata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MURC, a muscle-restricted coiled-coil protein, is involved in the regulation of skeletal myogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00188.2008"}], "href": "https://doi.org/10.1152/ajpcell.00188.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18508909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18508909"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Takehiro Ogata, Daisuke Naito, Naohiko Nakanishi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1315359111"}], "href": "https://doi.org/10.1073/pnas.1315359111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24567387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24567387"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Harriet P Lo, Ye-Wheen Lim, Zherui Xiong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201905065"}], "href": "https://doi.org/10.1083/jcb.201905065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34633413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34633413"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Naohiko Nakanishi, Takehiro Ogata, Daisuke Naito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MURC deficiency in smooth muscle attenuates pulmonary hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms12417"}], "href": "https://doi.org/10.1038/ncomms12417"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27546070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27546070"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Kotaro Miyagawa, Takehiro Ogata, Tomomi Ueyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of MURC/Cavin-4 induces JNK and MMP-9 activity enhancement in vascular smooth muscle cells and exacerbates abdominal aortic aneurysm."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.04.096"}], "href": "https://doi.org/10.1016/j.bbrc.2017.04.096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28433630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28433630"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Masahiro Nishi, Takehiro Ogata, Carlo Vittorio Cannistraci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systems Network Genomic Analysis Reveals Cardioprotective Effect of MURC/Cavin-4 Deletion Against Ischemia/Reperfusion Injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Heart Assoc (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/JAHA.119.012047"}], "href": "https://doi.org/10.1161/JAHA.119.012047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31364493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31364493"}]}]}]}
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| Synonyms | OR1-33 |
| Proteins | OR2G3_HUMAN |
| NCBI Gene ID | 81469 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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OR2G3 has 738 functional associations with biological entities spanning 6 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 46 datasets.
Click the + buttons to view associations for OR2G3 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by OR2G3 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of OR2G3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of OR2G3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR2G3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR2G3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR2G3 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of OR2G3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of OR2G3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of OR2G3 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing OR2G3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with OR2G3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR2G3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with OR2G3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by OR2G3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with OR2G3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR2G3 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR2G3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of OR2G3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of OR2G3 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving OR2G3 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving OR2G3 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving OR2G3 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing OR2G3 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by OR2G3 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by OR2G3 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by OR2G3 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of OR2G3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of OR2G3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of OR2G3 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for OR2G3 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of OR2G3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of OR2G3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving OR2G3 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR2G3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of OR2G3 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of OR2G3 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Reactome Pathways 2014 | pathways involving OR2G3 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving OR2G3 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR2G3 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of OR2G3 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of OR2G3 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of OR2G3 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of OR2G3 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of OR2G3 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with OR2G3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with OR2G3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
