| HGNC Family | G protein-coupled receptors |
| Name | olfactory receptor, family 2, subfamily T, member 4 |
| Description | Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008] |
| Summary |
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Moreover, SOX3 contributes to gonadal functions by influencing spermatogonial differentiation and is even capable of functionally mimicking SRY via upregulation of SOX9, thereby impacting sex determination."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA second group of studies in the set focuses on the enzyme arylacetamide deacetylase (AADAC), highlighting its role in hepatic lipid metabolism and xenobiotic processing. These abstracts describe how AADAC facilitates the hydrolysis of acetylated substrates—including therapeutically relevant compounds such as abiraterone acetate, ketoconazole, and melatonin derivatives—and thereby influences fatty acid oxidation, lipoprotein assembly, and the mitigation of drug‐induced toxicity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, despite the initial request to summarize the function of OR2T4, none of the provided abstracts mention or address OR2T4. The reports focus solely on the roles of SOX family transcription factors and AADAC in various developmental and metabolic contexts, leaving the function of OR2T4 undiscussed in this compilation.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jeffrey Weiss, Joshua J Meeks, Lisa Hurley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sox3 is required for gonadal function, but not sex determination, in males and females."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.22.8084-8091.2003"}], "href": "https://doi.org/10.1128/MCB.23.22.8084-8091.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14585968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14585968"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Karine Rizzoti, Silvia Brunelli, Danielle Carmignac, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOX3 is required during the formation of the hypothalamo-pituitary axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng1309"}], "href": "https://doi.org/10.1038/ng1309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14981518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14981518"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Gerald Raverot, Jeffrey Weiss, Susan Y Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sox3 expression in undifferentiated spermatogonia is required for the progression of spermatogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2005.04.013"}], "href": "https://doi.org/10.1016/j.ydbio.2005.04.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15893302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15893302"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Karine Rizzoti, Robin Lovell-Badge "}, {"type": "b", "children": [{"type": "t", "text": "SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.007906"}], "href": "https://doi.org/10.1242/dev.007906"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17728342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17728342"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Edwina Sutton, James Hughes, Stefan White, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of SOX3 as an XX male sex reversal gene in mice and humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI42580"}], "href": "https://doi.org/10.1172/JCI42580"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21183788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21183788"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Monica M Laronda, J Larry Jameson "}, {"type": "b", "children": [{"type": "t", "text": "Sox3 functions in a cell-autonomous manner to regulate spermatogonial differentiation in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2010-1249"}], "href": "https://doi.org/10.1210/en.2010-1249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21248142"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21248142"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Maria Bergsland, Daniel Ramsköld, Cécile Zaouter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sequentially acting Sox transcription factors in neural lineage development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.176008.111"}], "href": "https://doi.org/10.1101/gad.176008.111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22085726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22085726"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Kristie Lee, Jacqueline Tan, Michael B Morris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Congenital hydrocephalus and abnormal subcommissural organ development in Sox3 transgenic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0029041"}], "href": "https://doi.org/10.1371/journal.pone.0029041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22291885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22291885"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Li Zhao, Solsire E Zevallos, Karine Rizzoti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of SoxB1-dependent Sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2011.12.023"}], "href": "https://doi.org/10.1016/j.devcel.2011.12.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22421044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22421044"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Stephanie A Hoffmann, Deniz Hos, Melanie Küspert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.098418"}], "href": "https://doi.org/10.1242/dev.098418"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24257626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24257626"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Nicholas Rogers, Dale McAninch, Paul Thomas "}, {"type": "b", "children": [{"type": "t", "text": "Dbx1 is a direct target of SOX3 in the spinal cord."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0095356"}], "href": "https://doi.org/10.1371/journal.pone.0095356"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24751947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24751947"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "K S Alatzoglou, A Azriyanti, N Rogers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOX3 deletion in mouse and human is associated with persistence of the craniopharyngeal canal."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2014-1160"}], "href": "https://doi.org/10.1210/jc.2014-1160"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25140394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25140394"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Fatwa Adikusuma, Daniel Pederick, Dale McAninch, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Sequentially acting SOX proteins orchestrate astrocyte- and oligodendrocyte-specific gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.201846635"}], "href": "https://doi.org/10.15252/embr.201846635"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30166336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30166336"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Dale McAninch, Juho-Antti Mäkelä, Hue M La, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOX3 promotes generation of committed spermatogonia in postnatal mouse testes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-63290-3"}], "href": "https://doi.org/10.1038/s41598-020-63290-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32317665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32317665"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Dale McAninch, Ella P Thomson, Paul Q Thomas "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide DNA-binding profile of SRY-box transcription factor 3 (SOX3) in mouse testes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Fertil Dev (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1071/RD20108"}], "href": "https://doi.org/10.1071/RD20108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33166488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33166488"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jesse Rupprecht, Simone Reiprich, Tina Baroti, et al. 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|
| Synonyms | OR1-60, OR2T4Q |
| Proteins | OR2T4_HUMAN |
| NCBI Gene ID | 127074 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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OR2T4 has 861 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 49 datasets.
Click the + buttons to view associations for OR2T4 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by OR2T4 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of OR2T4 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of OR2T4 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR2T4 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR2T4 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR2T4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR2T4 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of OR2T4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of OR2T4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing OR2T4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with OR2T4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR2T4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with OR2T4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by OR2T4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with OR2T4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR2T4 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR2T4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of OR2T4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing OR2T4 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing OR2T4 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of OR2T4 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of OR2T4 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of OR2T4 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of OR2T4 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving OR2T4 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving OR2T4 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving OR2T4 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing OR2T4 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by OR2T4 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by OR2T4 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by OR2T4 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of OR2T4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of OR2T4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of OR2T4 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for OR2T4 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of OR2T4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of OR2T4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving OR2T4 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR2T4 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of OR2T4 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain OR2T4 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of OR2T4 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Reactome Pathways 2014 | pathways involving OR2T4 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving OR2T4 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR2T4 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of OR2T4 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of OR2T4 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of OR2T4 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with OR2T4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |