| HGNC Family | G protein-coupled receptors |
| Name | olfactory receptor, family 2, subfamily T, member 5 |
| Description | Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the provided abstracts directly discuss OR2T5, they collectively elucidate the multifaceted roles of a family of transcriptional corepressors—members of the Groucho/transducin‐like enhancer of split (TLE) family—that share mechanistic features with many regulatory proteins. In several studies, loss or altered regulation of TLE proteins (for example, TLE1) led to increased proinflammatory signaling through enhanced activation of NF‐κB and up‐regulation of inflammatory cytokines. In vivo experiments demonstrated that TLE1 deficiency not only predisposes to chronic inflammation in tissues such as skin, lung, and liver but also enhances responsiveness to Toll‐like receptor agonists, thereby modulating innate immune responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional reports emphasize that TLE family members are pivotal in developmental processes. For instance, interactions between Groucho/TLE proteins and neuronal transcription factors such as BF‐1 and Hes1 regulate cortical neurogenesis, with specific motifs (e.g., WRP[W/Y] and Eh1) being critical for their anti‐neurogenic function. In the developing heart, TLE proteins engaged by factors like Tbx20 assemble chromatin remodeling repression complexes essential for proper morphogenesis, while in lymphocyte development, distinct partitioning of TLEs with Runx and Tcf/Lef factors guides CD8+ T cell identity. Other studies report that TLE‐related proteins, including novel splice isoforms, can antagonize β‐catenin activation in the gut and participate in establishing dorsoventral patterning in the spinal cord. Moreover, TLE interactions with HESX1 play roles in pituitary hormone differentiation, underscoring the family’s broad contribution to context‐dependent transcriptional repression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Selvi Ramasamy, Borja Saez, Subhankar Mukhopadhyay, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1511380113"}], "href": "https://doi.org/10.1073/pnas.1511380113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26831087"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26831087"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jason L Larabee, Salika M Shakir, Soumitra Barua, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased cAMP in monocytes augments Notch signaling mechanisms by elevating RBP-J and transducin-like enhancer of Split (TLE)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.465120"}], "href": "https://doi.org/10.1074/jbc.M113.465120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23775085"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23775085"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Federica De Paoli, Corinne Copin, Jonathan Vanhoutte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transducin-like enhancer of split-1 is expressed and functional in human macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1873-3468.12029"}], "href": "https://doi.org/10.1002/1873-3468.12029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26763127"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26763127"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wei Chen, Daofeng Zheng, Tong Mou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tle1 attenuates hepatic ischemia/reperfusion injury by suppressing NOD2/NF-κB signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Biotechnol Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09168451.2020.1735928"}], "href": "https://doi.org/10.1080/09168451.2020.1735928"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32114961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32114961"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ji-Hao Xu, Guang-Cheng Chen, Can-Ze Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic modification of TLE1 induce abnormal differentiation in diabetic mice intestinal epithelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-017-3116-8"}], "href": "https://doi.org/10.1007/s11010-017-3116-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28744818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28744818"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nathalie Marçal, Harshila Patel, Zhifeng Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.24.10916-10929.2005"}], "href": "https://doi.org/10.1128/MCB.25.24.10916-10929.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16314515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16314515"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Manuel Buscarlet, Alessandro Perin, Adam Laing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of cortical neuron differentiation by Groucho/TLE1 requires interaction with WRPW, but not Eh1, repressor peptides."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M800722200"}], "href": "https://doi.org/10.1074/jbc.M800722200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18611861"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18611861"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Luciani R Carvalho, Michelle L Brinkmeier, Frederic Castinetti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Corepressors TLE1 and TLE3 interact with HESX1 and PROP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2008-0359"}], "href": "https://doi.org/10.1210/me.2008-0359"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20181723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20181723"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Erin Kaltenbrun, Todd M Greco, Christopher E Slagle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Gro/TLE-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/pr400818c"}], "href": "https://doi.org/10.1021/pr400818c"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24024827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24024827"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Shaojun Xing, Peng Shao, Fengyin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tle corepressors are differentially partitioned to instruct CD8"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " T cell lineage choice and identity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20171514"}], "href": "https://doi.org/10.1084/jem.20171514"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30045946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30045946"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Maina Lepourcelet, Ramesh A Shivdasani "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of a novel mammalian Groucho isoform and its role in transcriptional regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M208154200"}], "href": "https://doi.org/10.1074/jbc.M208154200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12359720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12359720"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Keith J Todd, Nathalie Lan-Chow-Wing, Adele Salin-Cantegrel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Establishment of motor neuron-V3 interneuron progenitor domain boundary in ventral spinal cord requires Groucho-mediated transcriptional corepression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0031176"}], "href": "https://doi.org/10.1371/journal.pone.0031176"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22363571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22363571"}]}]}]}
|
| Synonyms | OR1-62 |
| Proteins | OR2T5_HUMAN |
| NCBI Gene ID | 401993 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
OR2T5 has 1,037 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 42 datasets.
Click the + buttons to view associations for OR2T5 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by OR2T5 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of OR2T5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of OR2T5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR2T5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of OR2T5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing OR2T5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with OR2T5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR2T5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with OR2T5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by OR2T5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with OR2T5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR2T5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of OR2T5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of OR2T5 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of OR2T5 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of OR2T5 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving OR2T5 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving OR2T5 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving OR2T5 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing OR2T5 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by OR2T5 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by OR2T5 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by OR2T5 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of OR2T5 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of OR2T5 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of OR2T5 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for OR2T5 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of OR2T5 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of OR2T5 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of OR2T5 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving OR2T5 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR2T5 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of OR2T5 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain OR2T5 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| NURSA Protein Complexes | protein complexs containing OR2T5 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| Reactome Pathways 2014 | pathways involving OR2T5 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving OR2T5 protein from the Reactome Pathways 2024 dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of OR2T5 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of OR2T5 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of OR2T5 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of OR2T5 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with OR2T5 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
