| HGNC Family | G protein-coupled receptors |
| Name | olfactory receptor, family 2, subfamily Y, member 1 |
| Description | Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPRDM12 is an evolutionarily conserved epigenetic transcriptional regulator critical for the specification and differentiation of nociceptors. It initiates and maintains the expression of essential receptors, such as TrkA, by modulating the activity of Neurogenin transcription factors, and triggers a cascade of pro‐neuronal factors—including NEUROD1, BRN3A, and ISL1—that together ensure the proper development of pain-sensing neurons. Notably, its inactivation during embryogenesis leads to a complete absence of the nociceptive lineage, a defect that in humans manifests as congenital insensitivity to pain."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, PRDM12 exerts its regulatory function by recruiting histone-modifying enzymes such as G9a, which methylates histone H3 on lysine 9, thereby controlling chromatin dynamics and gene expression during neural differentiation. Its expression is inducible by retinoic acid in model systems like P19 embryonic carcinoma cells, where its overproduction leads to cell cycle arrest and differentiation, underscoring its role in the fine balance between proliferation and differentiation in the developing nervous system."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond developmental neurogenesis, PRDM12 continues to influence mature neuronal function. In adult dorsal root ganglion neurons, although it is no longer essential for cell survival, it regulates a network of genes that encode ion channels and receptors, thereby modulating neuronal excitability and specific pain behaviors—such as altered responses to capsaicin and formalin-induced inflammatory pain. Furthermore, PRDM12 contributes to the early establishment and maintenance of anorexigenic POMC neuronal identity, implicating it in energy balance regulation. Its reactivation in various cancers also suggests that it may play dual roles in oncogenesis, acting as both an oncogene and tumor suppressor in a context-dependent manner."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Luca Bartesaghi, Yiqiao Wang, Paula Fontanet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2019.02.098"}], "href": "https://doi.org/10.1016/j.celrep.2019.02.098"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30917305"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30917305"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Simon Desiderio, Simon Vermeiren, Claude Van Campenhout, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2019.02.097"}], "href": "https://doi.org/10.1016/j.celrep.2019.02.097"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30917309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30917309"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mark A Landy, Megan Goyal, Katherine M Casey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2021.108913"}], "href": "https://doi.org/10.1016/j.celrep.2021.108913"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33789102"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33789102"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Chia-Ming Yang, Yoichi Shinkai "}, {"type": "b", "children": [{"type": "t", "text": "Prdm12 is induced by retinoic acid and exhibits anti-proliferative properties through the cell cycle modulation of P19 embryonic carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Struct Funct (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1247/csf.13010"}], "href": "https://doi.org/10.1247/csf.13010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23856557"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23856557"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jiwon Woo, Haewon Kang, Eunice Yoojin Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Investigation of PRDM7 and PRDM12 expression pattern during mouse embryonic development by using a modified passive clearing technique."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.12.133"}], "href": "https://doi.org/10.1016/j.bbrc.2019.12.133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32000999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32000999"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Clara E Hael, Daniela Rojo, Daniela P Orquera, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Metab (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molmet.2020.01.007"}], "href": "https://doi.org/10.1016/j.molmet.2020.01.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32180559"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32180559"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Monica Rienzo, Erika Di Zazzo, Amelia Casamassimi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PRDM12 in Health and Diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms222112030"}], "href": "https://doi.org/10.3390/ijms222112030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34769459"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34769459"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Aurore Latragna, Alba Sabaté San José, Panagiotis Tsimpos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prdm12 modulates pain-related behavior by remodeling gene expression in mature nociceptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pain (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/j.pain.0000000000002536"}], "href": "https://doi.org/10.1097/j.pain.0000000000002536"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34961757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34961757"}]}]}]}
|
| Synonyms | OR5-2 |
| Proteins | OR2Y1_HUMAN |
| NCBI Gene ID | 134083 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
OR2Y1 has 900 functional associations with biological entities spanning 7 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 53 datasets.
Click the + buttons to view associations for OR2Y1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of OR2Y1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of OR2Y1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of OR2Y1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR2Y1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OR2Y1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR2Y1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR2Y1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of OR2Y1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of OR2Y1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of OR2Y1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing OR2Y1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR2Y1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with OR2Y1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by OR2Y1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores | diseases associated with OR2Y1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with OR2Y1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with OR2Y1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR2Y1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OR2Y1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of OR2Y1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing OR2Y1 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of OR2Y1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving OR2Y1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving OR2Y1 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving OR2Y1 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing OR2Y1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by OR2Y1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by OR2Y1 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by OR2Y1 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of OR2Y1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with OR2Y1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of OR2Y1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for OR2Y1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of OR2Y1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of OR2Y1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of OR2Y1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving OR2Y1 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of OR2Y1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of OR2Y1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing OR2Y1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain OR2Y1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by OR2Y1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of OR2Y1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| NURSA Protein Complexes | protein complexs containing OR2Y1 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| Reactome Pathways 2014 | pathways involving OR2Y1 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving OR2Y1 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OR2Y1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of OR2Y1 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of OR2Y1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of OR2Y1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of OR2Y1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with OR2Y1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with OR2Y1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
